| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | LINKS: Hyperacusis Support Discord: https://discord.gg/aPjEReVw6t Research Papers of Potential Interest: Psychophysiological Changes during Pharmacological Treatment of Patients with Obsessive Compulsive Disorder: https://1drv.ms/b/c/c31c9032179278c5/EYPdZBEZObxDkQZ_1BMGsNMBDl45QkkXK-c3vlqrydKFTA?e=W0itQX Study on anti-inflammatory and immunomodulatory effects of clomipramine in carrageenan- and lipopolysaccharide-induced rat models of inflammation: https://pubmed.ncbi.nlm.nih.gov/26740765/ Medication Compounding: https://en.wikipedia.org/wiki/Compounding Clomipramine SR 75mg w/ International Shipping (can use prescription from any doc, be prepared for shipping to take weeks): https://www.universaldrugstore.com/medications/clomipramine-hydrochloride-sr/ | |||||||||||||||||
2 | Subtype & Symptoms | Cause | Dose | Time on drug | Results | Side effects | Other info | Co-Factors (example: jaw/neck issues, OCD, history of trauma, etc) | Source | Last Updated | ||||||||
3 | pc42 | Severe loudness and pain hyperacusis since July 2025 Details: Immediate headaches after sound exposure that last hours. Immediate and lingering pain, bilateral loudness and pain H. The condition is severe: I cannot tolerate running water, lightswitch, talking, footsteps, distant noises | Acoustic trauma (Loud bass in headphones) | 25mg | Started clomi mid August at 25mg. Stopped after 3 days | Stopped after 3 days due to serious permanent side effects, namely VSS (visual snow syndrome). No change in H | Dry mouth, insomnia, dilated pupil, paraesthesia, reduced sex drive, VSS (after second day. No vision issues prior to clomi), MES (christmas bells), tremor, increased headaches, increased T volume. VSS and MES persisted after stopping clomi, other side effects went away | Moderate reactive tinnitus before clomi. While on clomi, my T was louder, but went back to baseline after stopping. Clomi also changed one of my annoying tones into a pleasant musical one, this persisted even after stopping clomi. In the past I attempted sound therapy, no change in H. | No co-factors | Discord | 2025-09-12 | |||||||
4 | Willers | Pain and loudness hyperacusis | Noise exposure | 25mg | One week at early september 2025 | None, quit due to side effects | ED and libido issues | Also suffers from ME/CFS Will likely try again later, starting from a lower dose | No co-factors | Discord | 2025-09-13 | |||||||
5 | Avin Pereira | Pain and loudness hyperacusis since March 2025 Details: mild loudness and pain H, the pain is located in the ears. The pain is immediate but sudden loud sounds can cause lingering pain for 1 week. The pain is mostly unilateral on the right ear. | loud music in the headphones on max volume. | 25mg - 50 mg (1 month) - 100 mg | Started in April 2025 | Aftrer clomi: So far I am on 100 mg living a near normal life | Reduced sex drive. At 100 mg: Musical Ear Syndrome | I haven't tried any treatment except some sound therapy like listening to pink noise while I was on clomi. | catastrophic OCD and suicidal tendencies. | Discord | 2025-08-22 | |||||||
6 | Lucriseo (in progress) | Pain and loudness hyperacusis since October 2024 Details: Pain in the outer ear canal mostly with stabbig, pinching, cut pain, Then deep inside the ear with acid burn, and then on both ears Nevralgia pain from the Eustachian Tube, both nose, ear and throat with mentol and sick feeling sensations. The pain is almost always delayed. The loudness was unilateral since acoustic trauma, then became bilateral after the statin. Noxacusis is unilateral on the offended ear from the acoustic trauma. | Acoustic Trauma and Statin medication | 10mg (5 days) 25 mg (5 days) 37.5 mg SR (5 days) 75 mg SR 150 mg SR 187.5 mg SR 225 mg SR | Before Clomi: the condition fluctuates between a severe and a very severe state. After Clomi: with clomi I'm finally reaching the moderate level. I couldn't tolerate nothing without ear protection. I'm also experiencing complete cure of the anxiety. I could also withstand without ear protection airplanes and typing and click on a keyboard and mouse. | Drowsiness is the one remaining side effect soo far. On the normal version I experienced increased libido, increased production of sperm fluid, flashes, increased heart rate, normal blood pressure (i suffer from low BP). On SR I only experience drowsiness and increased libido. | I had reactive T but it seems gone for the momen, but it increased my normal old T which I've had since I was 2 years old. I've also had MEM that subsided thanks to Magnesium citrate powder. Before clomi I have tried B12 folic acid, pre natal supplement, Magnesium citrate powder. | I had extreme anxiety that became OCD tendencies due to PTSD from Being a rape survivor, and right before the H onset I had bruxisms destroying two of my molars on the opposite side of my offended ear, which then developed TMJ which appears to have been fixed. | Discord | 2025-09-12 | ||||||||
7 | Kartveli | Pain hyperacusis since March 2024 Details: Stabbing, earache, burning pains, I feel immadiate pain when hear sound in occipital nerve, also trigaminal nerve pain, back of the ear nerve pressure pain, under the ear, throat vagus nerve pain both side, neck pain, electric shoch pains in the head random areas, eye pain after sharp sound. The pain is bilateral, both immediate and delayed. | Significant noise exposure from electronic music concert- 1 hour under and next to the speaker (120+db high frequency sounds) | 6 mg (1 week) 12 mg | two weeks | Before Clomi: when i started clomi my pains was unberable, I had flight and was taking noofen(phenibut) after I went in my home country i couldn't go outside my room, I was also taking Clonazepam which reduced a bit the pain, but even slight sound was immadiately giving me extreme pain especially facial and stabbing pain. I could not tolerated up to 30db. After Clomi: It caused me side effects, had increased earache pains, increased stabbing pains, significant drowsiness, sweating alot, headaches. | It caused me allodynia, which is pain from touch, or even pain from slight wind. The pain was in the knees, feet, back, shoulders, face. The pain was a stabbing nerve sensations all over the body. Even with high temperature I was wearing soft shirts and soft clothes to avoid even the slightest wind. | I had very stable low frequency Tinnitus 1/10, after Clomi it started extreme reactive and pulsatile tinnitus. Before clomi I have tried the medications called Noofen (phenibut) and Clonazepam (biggest savior). | Before trauma I had major depressions, ADHD | Discord | 2025-07-23 | |||||||
8 | Flemboy | Pain hyperacusis | Listening to loud music with earbuds | 225mg (3x 75mg spread over the day) Normal version (not slow release) | Several months | Clomipramine helped with his OCD and depression, but he felt like it did little for his hyperacuis. He did improve a little bit but attributes this more to time. He decided to taper down and eventually quit the drug. | Lower libido, harder to climax, excess sweating and dry mouth | Decided to quit | OCD | Discord | 2025-07-15 | |||||||
9 | AnyConsideration9682 | Loudness hyperacusis since 2021 | cause i dont know when i will start it again | 25-100 mg | 10 days | June 17, 2025: I started with 25mg and first day I had kidney pain when I would wake in the morning. I stopped and the pains went away. I later tried it again and just dealt with the pain and quickly got up to 75mg for at least a week and it didn’t help the H whatsoever | "Extreme" kidney pain | Quit due to side effects | Patulous eustachian tubes and minor anxiety | 2025-07-03 | ||||||||
10 | Leofrav | Unknown | 25mg | Four days | March 19, 2025: I was using for 4 days until now. 25mg. My mouth is dry all the time. Everytime I get up from a chair or my bed after 20 minutes or more my vision get all dark and I feel that I could colapse on the floor or have a stroke. I was expecting that since I read about it in the medicine leaflet, but that's happening so often that's getting me tired. I barely started and I'm already thinking about finishing this treatment experience and try another medicine from that thread. update: i didnt take clomipramine for one day and that side effect disapeared. im so mad, now that i find a medicine for hyperacusis my body cant deal with it. | Dry mouth, dark vision, "feels like getting a stroke when getting up from a chair", fatigue | Quit due to side effects | 2025-07-03 | ||||||||||
11 | Jim (anonymous) | Pain & loudness hyperacusis for 30+ years since age 21 Details: The pain is both aching and stabbing in nature. It worsens with noise exposure but never fully disappears. There is always some baseline pain. The pain can be both immediate and delayed. Some sounds cause instant discomfort, while others result in lingering pain that lasts long after the exposure ends. | Acoustic trauma (cumulative) | 25mg twice a day (50mg total per day) | Started Summer 2023 | Before Clomi: Nearly all sounds were distressing. Everyday noises like dishes clattering or objects dropping were painful. Sudden or sharp noises, such as barking dogs or raised voices, were especially intolerable. I experienced ongoing suicidal ideation for many years due to the intensity and relentlessness of the condition. Now: Since starting clomipramine, I have experienced improvement in all areas: • Significant reduction in pain • Better sound tolerance • Greater ability to go out and function in the world • Emotional relief and improved mental well-being My quality of life has improved significantly. With the combination of clomipramine and custom musicians’ earplugs, life is much more manageable. I still avoid noisy environments whenever possible, but I am no longer overwhelmed on a daily basis. Examples from wife: - Sounds are much quieter now. "Before if I dropped something he will jump out of his skin 🙁 and that has changed ….. sometimes he doesn’t even realize some noises that I think are too loud" - "And the main difference is that for example if a dog barked while we were outside in one of our hikes he will be in pain for days ….. that doesn’t happen anymore" | I developed urinary retention as a side effect. To manage this, I reduced my dosage from three times daily to twice daily, which helped alleviate the issue. | I grew up on a ranch and began shooting guns at age 10, especially shotguns, without hearing protection. At the time, even my hunter safety course did not mention hearing protection. I believe this early and repeated exposure to firearm noise caused my hyperacusis. I have been on clomipramine for approximately two years. I do not recall exactly when the benefits began, but it was likely within one to two months. Before clomipramine, I tried nearly every class of antidepressants, as well as: • Acupuncture • Oval window surgery (non-updated version, this did help) • Tinnitus Retraining Therapy (TRT) • Gabapentin (which I continue to take at a dosage of 600mg three times a day) Tinnitus has not been affected by clomi Has found custom molded musician's earplugs very helpful | None reported | 2025-06-28 | ||||||||
12 | Rbk_3 (in progress) | Pain hyperacusis since July 2024 Details: Dull aching in middle ear area started after I bought new headphones last July. Got worse after going to a fair and then developed tinnitus. Usually delayed that can last days depending on exposure. No loudness. No improvements over the past year, but could live fairly normally in earplugs except around very loud noises. Any level of digital audio caused delayed ache. | Acoustic trauma | 25 mg --> 50 mg --> 100mg --> 125mg --> 150mg --> 200 mg | Started June 2025 | Before Clomi: 4/10 aching at worst couldn’t tolerate anything over 60db without earplugs no digital audio at all June 13, 2025: Definitely already noticing an improvement; had ear plugs out a decent amount last couple days only a minor discomfort 10 days at 200 now and I continue to improve each day that passes. Have had no real pain or discomfort despite not wearing my plugs and listening to a lot of audio all weekend. Clomi is working better than I could have ever hoped August 11, 2025: 20 days at 200 now and I continue to improve each day that passes. Have had no real pain or discomfort despite not wearing my plugs and listening to a lot of audio all weekend. Clomi is working better than I could have ever hoped | tolerating very well; a little trouble sleeping and low appetite, sexual issues and constipation | I have T, not sure if it is reactive, gets louder after noise exposures. Doesn’t change tones or anything. No TTTS/MEM Previously tried 20mg of Amitriptyline for a month | None reported | Reddit/Discord | 2025-08-01 | |||||||
13 | Koenic (in progress) | Loudness Hyperacusis since September 2024 Details: H started on september 2024, but I think I had a kind of sound sensitivity even before this. I have a kind of little pain, but is very rare, it's like a sting in the ears. Bilateral H | probably a loud applause + stress | 25 mg --> 35 mg --> 50 mg --> 75 mg | Started April 2025 | Before Clomi: I think before Clomi was mild. I could tolerate lot's of sounds, even at 70-80 db, but I couldn't tolerate acute and sharp sounds June 8, 2025: My mood is improved | Aphatetic for a short time, I wanted to sleep a lot. Now these side effects are improved. Tinnitus has increased by 20-30% | I was listening music with earbuds and I developed bilateral T in 2018 | None reported | Discord | 2025-08-04 | |||||||
14 | mandalink (in progress) | Loudness hyperacusis since 2022 Pain hyperacusis since 2024 Details: Pain was very bad stabbing and intense burning and intense aching. Both immediate and delayed pain. | Noise-induced | 150mg + (regular/not SR) | Started March 2025 | June 5, 2025: About 65% better overall; I have TTTS/MEM that also got better on clomi | Long to climax, no other side effects | Tinnitus used to be insanely reactive but is now much better. Clomi temporarily spiked it in the beginning Tried Gabapentin that didn’t work well since it was low dose Only a minor amount of natural improvement prior to clomi | Jaw and neck issues, VSS (important that it is VSS and NOT VS) | Discord | 2025-06-05 | |||||||
15 | Anahita | Pain hyperacusis since November 2023 Details: Severe nox in my left ear and moderate nox in right ear. In July 2024 I had a series of horrible setbacks and nox in my left ear became severe. Pain begins 5min-30 min after exposure. The pain goes on for at least 3 hours and in case of very loud sound it can go on for a few days. | noise-induced (likely from earbuds) | Began at 10mg and increased to 200mg over 3 months | Began september 2024 | April 30, 2025: I’ve had pain hyperacusis since November 2023. Severe nox in my left ear and moderate nox in right ear. In July 2024 I had a series of horrible setbacks and nox in my left ear became severe. I’ve been home-bound for 9 months now and I still can’t go out.I started taking clomipramine in September 2024. I’ve been on 200 dosage for 4 months now. But the improvements have been very very slow. I’m like maybe 20% better.I can tolerate my own voice and people’s voice much better. But I still can’t take a shower without earplugs on. I still cannot listen to digital audio even the lowest volume without horrible pain and still cannot tolerate clicking sounds of plates and culinary. I live in Iran. I’m taking the clomipramine that is produced here. But I also have 100 tabs(dose 75)that are produced in Germany but they’re sustained-released. I tried the sustained-release ones for about 3 days but I felt like the regular ones were more effective. Update June 2025: Compared to September 2024, the intensity of the pain has decreased by 30-40%. I can tolerate the sound of car horns much better. But I’m still home-bound. Clomipramine has prevented me from having setbacks. I plan to take clomipramine until I get healed. | very dry mouth, sweating, slight dizziness, spike in tinnitus, musical hallucinations, mild/moderate constipation, slight spike in VSS(nothing too serious) , tremor, sometimes low blood pressure, low sex drive . Positive effects: improved OCD, less menstrual cramps. | My psychiatrist also prescribed Risperidone 1 mg so I could take it in addition to clomipramine. I’ve been on Risperidone since February 2025. | None reported | 2025-06-05 | ||||||||
16 | BettyOddler (in-progress) | Loudness hyperacusis Sounds are sharp. Is constnaly in ear pro, cannot talk or go outside much | Multiple acoustic shocks and chtronic stress | 10-30mg over 1 month | Began August 2025 | Perhaps sounds are slightly less sharp | Slightly raised heart rate and some minor and temporary tinnitus spikes | Half deaf and has always been sensitive to sounds to some extent | OCD and PTSD | 2025-09=19 | ||||||||
17 | Uncle_Meat (in progress) | Loudness and pain hyperacusis since January 2025 Details: The most common is an ache, (it tends to become burning or stabbing if it gets worse). Loudness is bilateral, Pain is mostly in my right ear (although my left has had some issues as well now. The pain is both instant and delayed. It was relatively minor till a major setback just before starting clomipramine, after which it got bad but not catastrophic. Still can’t tolerate most sounds without double pro, but I am able to have conversations (softly) | Most likely an acoustic trauma from forgetting to set my headphone volume to zero. | 25mg --> ... --> 200mg | Started early February, 2025 | After clomi: Major improvement in OCD symptoms, no major improvements painwise. August 21, 2027: Loudness hasn't gotten any better, but I rarely have pain from a lot of sounds that used to always cause pain. I'm still wearing protection all the time, but I'm taking the earmuffs off more than I did in the past. | Fatigue, constipation, increased appetite. All seem to have faded by now (although the fatigue does come back a bit after dose increases) | Tinnitus is reactive, but the clomipramine seems to have helped a lot with that so far (the volume is in general lower and more tolerable). I also have TTTS. Clomi has had some effect on them (less intense, but still bothersome) | Neck/jaw issues, OCD, health anxiety, extensive trauma history, TMJ | Discord | 2025-08-22 | |||||||
18 | Mecanico18714 | Loudness hyperacusis and tinnitus | Tinnitus appeared the day after testing a loud muffler system, potentially also related to stress. Loudness hyperacusis followed about three weeks later | 6.25 - 12.5 mg | between three days and a week | I tried 12.5 mg/d x 3 days the first time but gave up after T spiked and felt a little lightheaded. Second try I went 6.25 mg/d x 3d, then upped to 12.5 mg/d x 3 more days then had to stop. The third and fourth trials were a repeat of trial 2 above, except I got to about a week trying to wait and see if the T spike would settle but it never did and I got too uncomfortable with the T spikes and gave up. HTH. Also lots of dry mouth the 3rd and 4th tries. | Severe tinnitus spike, terrible dry mouth and a bit of lightheadedness Side effects went away and T went back to baseline 24h after stopping the drug. | Quit due to side effects Recovered from MBS approach | Stress | 2025-05-24 | ||||||||
19 | Vivi (in progress) | Pain hyperacusis since August 2019 Details: Acoustic Trauma end of August 2019 with minor symptoms. Noxacusis and T really developed from March 2020 onwards, after using headphones whilst WFH. I have unilateral Noxacusis (right side) only, no Loudness H. Pain is mainly acid, burning, electric shock type feeling. Numbness, tingling, dull ache. I get electric shocks from pulling at my ear or when exposed to loud sudden impulse type noises (the closest thing to feeling like a stab for me) Pain is mainly around my right ear, face, cheek, jaw and back of head. Spreads down to my right neck, chin, shoulder, back when bad. I have some constant low level pain in the right side of my face all of the time. There is some immediate increase in intensity with sound, but most of the pain is delayed, building up and lasting for many weeks during a bad setback. | Acoustic trauma - very loud noise (>120dB). Left ear was protected with ear defender, right ear was exposed for less than a second. | 10 mg --> ... --> 75mg --> ... -> 150 mg | Before clomi: I would say I’m a moderately severe case. My tolerance to sounds is pretty low. I use ear plugs and noise cancelling headphones when outside, but 95% of my time is spent indoors at home. My lifestyle is highly adjusted to manage my Pain H. The worst triggers for me are the loud sudden impulse type noises, similar to that of my initial Acoustic Shock. My tolerance to sounds is generally low. I struggle with being in the kitchen, cutlery, digital noise, water, etc. With clomi: Clomi 75mg is providing some pain relief for me. The low level constant pain in the right side of my face is more or less gone. I used to get pain from using earplugs but this has mostly disappeared. I still get some pain from wearing noise cancelling headphones, but it’s less intense and is quicker to go away. I feel that I’m able to tolerate more sound and at slightly higher volumes than when taking Duloxetine, although my tolerance to sound generally remains low. Also my anxiety and general mood is much improved on Clomipramine compared to Duloxetine. My family have noticed I’m much happier and more like my old self. I wouldn’t say it’s a significant or major improvement so far, but things are definitely heading in the right direction. Hoping that increasing the dose to >= 150 mg will improve things further. | Feeling sleepy, taking naps (I never usually nap). Constipation. I have some static in my vision (VSS?) but this doesn’t seem to be any worse with Clomipramine. I sometimes feel more sensitive to light but it’s tolerable. Visual hallucinations when waking in the middle of the night. Dry mouth, especially after exercise. Feeling sick, especially when I’ve not eaten. Sour, bitter, metallic taste that comes and goes. All of these have improved with time. Usually worsen during a dose increase but settle back down. | Bilateral tinnitus, worse on my right side, but my T is generally tolerable and does not bother me. With Clomi, my T can sometimes seem slightly louder and “more active”/fluctuating in tone, but it has remained tolerable. No significant worsening. I believe I have TTTS and the associated thumping in my right ear. With very loud noises, the sensation is like an electric shock through my right ear. This still seems to be present on Clomipramine but has improved, i.e., it happens less and when it does happen the sensation is not as strong as it used to be. Less electric shock type feelings in my ear I’ve tried different medications to help with the pain and anxiety that Noxacusis presents: Duloxetine - as mentioned. Fluoxetine - Useful for anxiety/depression Carbamazapine - Helps with facial pain (trigenminal neuralgia/nerve). Meloxicam - for pain but not effective for noxacusis. Pregabalin - Reduced nox pain but came with more side effects. Propranolol - Useful for anxiety, no effect on pain. | History of anxiety and some emotional trauma. History of concussions. | Discord | 2025-05-05 | ||||||||
20 | da-gan (in progress) | Pain hyperacusis since June 2023 Details: bilateral burning, aching and in the beginning stabbing pain, inside the ears and on the whole outside of ears, left side of face, neck, throat, mouth and back. The pain is both istant and delayed, mainly delayed. | Acoustic trauma | 10 mg --> 37.5mg SR --> 75mg SR --> 112.5 mg SR --> 150 mg SR | Started March 3d, 2025 | August 15, 2025: I have been doing 150mg for 2,5 months now, I have seen improvement in tolerating cutlery and plates, can speak longer with people without plugs, can do some things with like going to a minor store in single pro now, maybe 20-30% overall improvement, digital is the most disappointing, no improvements at all there. Its no cure by any means, but I have seen some improvements. Pain is mostly gone if I'm careful. | Headache, muscle stiffness, dry mouth, sickness/flu feeling, increased and constant ear pressure, increased ttts clicking, tinnitus spikes, nausea, tremors, musical tinnitus/MES, auditory hallucinations, dysacusis, anorgasmia and tiredness. Yes side effects have improved now mostly tiredness, anorgasmia, musical tinnitus/MES and dysacusis. Mild photophobia at the beginning of the treatment, now gone. August 15, 2025: Side effects are mostly gone except for extreme fatigue, anorgasmia and slow gut motility. Tinnitus might even be slightly better now than before I started. | Tinnitus, not reactive, the tinnitus turned musical with auditory hallucinations and dysacusis I have TTTS, they increased at first but then returned to normal, now maybe increasing again, now it's enough to turn my head to start the clicking | None reported | Discord | 2025-08-15 | |||||||
21 | Yassine (in progress) | Loudness hyperacusis and pain hyperacusis since 2018. Details: Pain feels like a sharp, piercing sensation deep in my inner ears. I also feel a kind of burning sensation, especially after longer exposure to sound. Sometimes I can tolerate a sound for a while before the pain sets in, especially if the volume is low. But in other cases—especially with sudden or high-pitched noises—the pain is almost immediate and can linger even after the sound stops. | Acoustic trauma (rock shows and high volumes on headphones) | 25mg --> 50mg --> 75mg (plans to increase further to 150+) | Started 2024 | Before clomi: My hyperacusis was quite severe. I couldn’t tolerate digital sounds at all—even at low volume. Things like phone notifications, or watching videos with any kind of background noise would cause discomfort or pain. With clomi: So far, the results have been good. I’ve regained some tolerance for digital sounds—I can now listen at low volumes for controlled periods without triggering pain. It’s not perfect, but it’s a meaningful improvement compared to where I started. | In the beginning, I experienced some drowsiness, dry mouth, and mild constipation, but these side effects have eased up over time. Now, I feel more stable and haven’t had any major issues from the medication. | I first tried an SSRI after my initial trauma, and it helped to some extent—I was on No-Dep (sertraline) 50 mg. But after a second acoustic trauma, No-Dep stopped being effective. That’s when my doctor suggested switching to clomipramine. I started with 25 mg, then moved to 50 mg, and now I’m on 75 mg. I’m taking the regular (immediate release) version, usually in the evening. Does not have tinnitus, TTTS, or MEM I’ve tried supplements like magnesium and ginkgo biloba, but unfortunately, they didn’t make any noticeable difference. I did notice some gradual improvement over time after the trauma—especially when I avoided loud environments and gave my ears time to rest. But the major turning point came when I started clomipramine. | I don’t have any known issues with my neck or jaw, no OCD, and no other history of trauma besides the acoustic one. | 2025-08-22 | ||||||||
22 | Dexter (in progress) | Moderate loudness hyperacusis and severe pain hyperacusis since November 2018. Details: Loudness H since November 2018. Noxacusis since December 2022. Stabbing and burning pain. Stabbing in the ears and burning in the left ear and left side of the face. Both immediate and delayed pain.Bilateral pain | Prolonged noise exposure. Worsened by acoustic shock. | 10mg --> 20mg --> 37.5mg SR --> 75mg SR --> 112.5mg SR --> 150mg SR --> 187.5 mg SR | Started April 11th, 2025 | No change yet | Dizziness, increased burning pain in the face (not sound-induced), increased bruxism. Fatigue. Dry mouth. May 1st, 2025 report: all side effects have disappeared except for dry mouth | Reactive tinnitus and TTTS not affected by clomipramine. | Bruxism. GERD. | Discord | 2025-05-23 | |||||||
23 | Soph (in progress) | Very severe loudness & pain hyperacusis since August 2023 Details: My noxacusis pain is constant 24/7. It's burning and has an acid like feeling, sometimes stabbing. It's deep in my ears, jaw, cheekbones, mouth, teeth, gums, tounge and scalp. The pain is bilateral and constant, it gets worse with sounds, delayed pain. | PTSD (severe anxiety and stress, sleep deprevation). | 10mg --> 75mg SR --> 150 mg SR --> 187 mg SR | Started April, 2025 | After clomi: My pain and loudness have improved a lot on 187.5 mg Clomipramine. i dont’t considerate myself a catastrophic case anymore, I’m more like moderate Im happy to say. I can be outside with custom earplugs, go shopping etc. Im so unbelievable thankful and happy. (Notes: it's combined with lamotrigine and LDN). My MES and reactivity have also improved. | Migraines, racing heart and dry mouth | I have reactive multitonal tinnitus and MES (musical ear syndrome). Clomipramine hasn’t affected it so far but its very bad from the beginning so I don’t really even know if I could tell any difference. | I have muscle spasms and fluttering inside ear. So far no effect on this. | Discord | 2025-09-19 | |||||||
24 | valo (in progress) | Severe Loudness and Pain Hyperacusis since March 2021. Details: My mild pain hyperacusis started in 2015 and became severe after a setback in 2021. My pain is bilateral, mainly delayed, burning and aching. My loudness H is bilateral, perhaps more pronounced on the left side. | Acoustic trauma, sound Exposure | 10mg --> 20mg --> 37.5mg SR --> 75mg SR --> 112.5mg SR --> 150mg SR --> 187.5 mg SR --> 225 mg SR | Started March 1th, 2025 | At 225 mg: A certain reduction in the duration of the setbacks. Minimal improvement in the pain threshold. No effect on loudness H. Overall largely insufficient results. | Sexual issues, mild temporary VSS spike, fatigue, mild blurry vision, mild tinnitus increase. The side effects were more pronounced at the start of the treatment. Fatigue kicked in at 20 mg. I generally notice a reduction of the side effects starting from 4-5 days from the dose increase. The sustained release seems to decrease the side effects. Update may 2025: Dry mouth, dry eyes, slight tremors, slight dizziness, jerks, Diahrrea (resolved), constipation. Fatigue and dizziness remain. Weight gain, increased appetite, orthostatic hypotension, rarely visual hallucinations | Mild multi tonal tinnitus, slighty reactive, moderate in the worst days. Significant TTTS. The middle ear muscles react to most sounds, particulary impulsive sounds. Ability to contract TTM | Neck tension and structural congenital issues. Chronic fatigue syndrome, chronic pelvic pain | Discord | 2025-09-12 | |||||||
25 | Gomuscu (in progress) | Loudness & Pain (delayed pain) Hyperacusis Since February 11, 2024 Details: I suffer from auditory hyperacusis, everything sounded too loud, especially high notes and "S" sounds in sentences. Also pain for months; I had in one ear (left) an acid-like burning sensation that spread around the auditory system sometimes for several days and a sensation of "open wound"; in the right, it came later, not the same pain, a "burning" type pain directly in the ear canal. Sometimes I had facial pain mainly in the jaw, in reaction to noises. I consider my nox, at its worst as mild/moderate 4-5/10. It has decreased with time, confinement and the wearing of permanent earplugs to 0-2/10. I don't know where to place this, but I also suffer from auditory fullness sometimes significant in the form of liquids behind the eardrum and stinging. The pain was delayed most of the time. It was instant auditory fullness and the pain would come the next day or days after. bilateral; but the pain was worst on the left where I suffered a major setback (car horn 1m from my ear that triggered pain, shortly after my trauma) | Acoustic trauma (nightclub) | January 29th, 2025: 5mg February 2nd: 10 mg February 14th: 15 mg February 21st: 20 mg February 28th: 30 mg March 7th: 40 mg Most recently: 150mg May 25th: 175mg June 2025: 200 mg *Using regular version (not SR) September 2025: taper to 37.5 mg | Started January 29th, 2025 | Before clomi: I considered myself a moderate H sufferer. I couldn't remove my earplugs except in complete silence or very low, soft background noise (nature). I couldn't tolerate any bumps/pops; I couldn't talk to anyone without earplugs (double pro at my worst); I couldn't crumple paper or plastic wrap; I couldn't chew hard things (at my worst); I couldn't hear any digital audio for months because it made me feel worse; I couldn't hear birds, barking, etc.; I couldn't cook/dishwashers, etc., even with earplugs; I couldn't drive with my earplugs. I had my groceries delivered to my home. I was confined to my house from July to December 99% of the time. I could only live and communicate with my partner. I started to tolerate noise a little better in December and went out a little, but it wasn't enough to remove my earplugs in any situation. After starting clomi: When I went from 20 to 30 mg, the very next day, I felt like I could tolerate things I couldn't before. That's also when I started to feel the side effects (sweating and low libido) Since switching to 30 mg, I've started to feel the first positive effects: The volume has decreased; popping/snapping sounds are less painful; words with S sounds in sentences no longer sound so much like a "broken speaker." Clomi has taken away what little pain I had left. I can take my earplugs out at home 90% of the time; I can talk to my partner at a low volume again without pain. I can listen to some digital audio at low volume without setback or pain (I still have some hearing loss). I can drive and go shopping, and go out on the street with just foam earplugs. I put in earplugs and can see my friends in small groups. I'm far from cured, but I'd say I feel 20-30% better than before Clomi. I will continue to increase it slowly and hope to improve further. My left ear was my worst ear and the one with the most pain. Since I switched to 30mg, it has become my best ear... It had hardly ever improved before; it was the right that improved more easily 2025-05-25 Update: I feel 75% better at 150mg (normal version), and I'm gradually returning to my normal life. I still use earplugs only in noisy places like bars or the subway, for example. My tinnitus has also improved 2025-06-27 I've been back at work for a week, and I'm doing well! Still 80% better, only loud noises/electronic beeps and high-pitched frequencies are still bothersome. I'm staying at 200 mg, but I'm hesitant to increase to 225 mg because the ear fullness symptom still persists too often. It's the only symptom with my T that reminds me that I'm not yet cured. Current side effects: Sweating, total anorgasmia. TTTS has disappeared. The hearing fullness is the only symptom still quite present, but it's 50% better 2025-09-17: I stopped taking Clomi in August... What a joy to no longer have side effects... but I gradually relapsed... before I could no longer work, I started taking 37.5mg again 4 days ago. I immediately feel much better, even the tinnitus has calmed down. This medication works really well, I just hope I don't have to depend on it all my life | Fatigue, night sweats, and decreased sexual sensation The fatigue disappeared over time; the other two are still present but very bearable. | I've had T my whole life, but insignificant to the point of never thinking about it. Since my acoustic trauma, I have bilateral multitonal T, that's significantly higher on my right ear (where I have the most fluid in my ear). T is not reactive, where it's almost imperceptible. T has improved over time (from 8/10 to 4/10). Clomi didn't affect my T. At first, I thought it might have increased after reading about other people's side effects, but it was mostly psychological, due to fear of this side effect. Other treatments tried: Benzo (Ativan) to help me sleep because of the tinnitus during the first 3 months after my trauma. Ambroxol last fall (60 mg/day); it seems to have helped a little with the pain. I haven't taken it for weeks. I developed TTTS following a major setback (car crash) in my left ear. I suspect it may have developed an acid-burning Nox around my ear. It subsided over time but persisted. Since feeling better with Clomi, I no longer feel my eardrum vibrating (did Clomi help?). With the fluids in the ear, I suspect ETD in my right ear. | Night bruxism that I have been trying to treat for several months with a night guard. | Discord | 2025-06-27 | |||||||
26 | MM (in progress) | Loudness hyperacusis | 25mg-200mg | Started around January 2025 | Loudness H 70% better | Fatigue, heartburn (now takes omeprazole for heartburn) | Plans to stay at 200mg for 6 months and begin process of tapering off over a two month period Minor tinnitus in right ear which is "very manageable" | 2025-03-08 | ||||||||||
27 | AA (in progress) | Loudness hyperacusis, mainly pain hyperacusis (burning and stabbing) since April 2024 Tinnitus since April 2021 | Noise | 25mg-150mg | Started August 2024 | "Since the first pill I took I could feel my noxacusis getting better but it was very slow. I’d still have some bad days and that would make me think, great, it’s not working, but one I hit 75mg I noticed a big difference, to where the pain was gone but I still had the burning. Now, on 150mg, I have days where I forget I even have nox, I have gone as long as a week with no pain or burning! Then I’ll have some slight burning and very small amount of pain but it’s soooooo much better and then I have days where I have no pain or burning at all. I’ve thought about upping to 200mg but I think I’ll just stick to the 150mg since it seems to be helping" | Meniere's, migraines, possibly neck issues | 2025-03-08 | ||||||||||
28 | Dutch4991 (in progress) | Very minor loudness (measured 75-80 LDLs), mostly noxacusis (most sounds above 40dB causing pain) since April 2024 Aching and stabbing pains immediate with sound Had scalp pain but not really facial; sometimes across temples H was bilateral but worse in right than left (right exposed to longer duration microsuction) Tinnitus (moderate, only mildly reactive) since March 2024 | Lexapro started tinnitus in March 2024, microsuction in April 2024 caused noxacusis | Started at 12.5 mg 175mg as of 2/26 *regular release | Started November 2024 | 2/26: 95% recovered; rarely ever in pain now and if so 0.5-1/10; went to a wedding on the weekend and didn't wear plugs after basically missing every social event last year Didn't really feel much at all until 125 and have had bumps at 150 and 175 which were significant. Hoping that if I go to 200 I will kill even the tiny tiny pain that's left | significant drowsiness, major sweating, and increased HR No effect on tinnitus | Natural improvement prior to clomi? "I would say zero, if anything I would say I was slowly getting worse due to having to continue to work; have a mortgage to pay" Experienced pain "bouncing from ear to ear" often I have thumping in the ear if I blink too hard or tense my face, but it’s unchanged by clomi | Diagnosed with TMJ and anxiety | Discord | 2025-02-27 | |||||||
29 | Wonderful-Law-719 (in progress) | Loudness & Pain Hyperacusis since May 2023 Burning, aching pain in inner ear that radiates to jaw MEM (thumping) Pain is generally delayed and progressively worse over next 24 hours after exposure | COVID vaccine, COVID infection and subsequent noise injuries | 8 mg 1 week 12 mg 1 week 17 mg 1 week 25 mg 2 weeks 37 mg 2 weeks 50 mg 1 week so far *regular release | Started December 2024 | Before Clomi: Pretty severe, homebound and avoided most normal household "sharp" noises; Volume VERY low or off on TV, Phone, Zoom calls, etc. relied on close captions. Would use ear filters (EarPeltor or 3M plugs, depending on the situation. If outdoors, would use 3M Peltor muffs if any chance of noise (cars, trains, planes, landscapers) With Clomi: @ 25mg, started noticing that sounds starting to sound more "normal", better at 37 mg and even better at 50 mg (not cured but probably 50 percent better than at my worst); MEM is somewhat better but occasionally still get thumps 75mg Update 5/23/25: Been at 75 mg for about 3 months now. All good at this dose. I feel that I am getting closer to my prior baseline. No pain. Only minor loudness H in louder environments without ear filters. Otherwise, All side effects have calmed down. MEM has also resolved. | difficultly reaching climax, musical hallucinations at 50 mg, worse tinnitus but even though my tinnitus is pretty bad, it doesn't bother me too much since completing a course of CBT for tinnitus UPDATE: As of 5/23/25 after 3 months on 75mg, "all side effects have calmed down" | None reported | 2025-05-23 | |||||||||
30 | Memewizard (in progress) | Loudness Hyperacusis and Mild Aching (Bilateral) since 2015 | I got hit by a ladder, I recovered 95% and was healed for a couple of years, but a dog barked into my ear, and relapsed | 5mg-150mg (SR) + | Started October 30, 2024 | 2/1/25: unexpected sound doesn’t trigger same reaction as before 2/4/25: After a couple of days (at 112mg SR) I see HUGE difference. Far less aching/pain, my sound tolerance went UP, my sound awareness/anxiety is almost gone 2/15/25: I continue to improve. Ear pain is gone, and I can feel it only in the morning before I take my dose. Sound tolerance is continuing to improve. Could drive highway 160 km/h no problem, Went to dentist with no plugs no problem, went to hairdresser no problem. Side effects: +15-20 minutes to climax, dry mouth, headaches; says all improvement happened from 75mg+ 2/27/25: "I start forgetting I have H. Since 150mg it's very minor. Almost never feel the pain and don't have aching anymore. Started listening to music on computer again at very low sound setting. Before it was impossible" | Lower doses: Increase in Tinnitus (20-30% more, can't tell if it went back to baseline now or just habituated), more aching, anxiety 2/4/25: hard to climax during sex, headaches, dry mouth Says 20-30mg was worst in terms of side effects; had panic attacks and more pain at 30 | Mild tinnitus, reactive both before and after clomi; also helping fibromyalgia pain (was taking duloxetine for fibromyalgia before but that did not help H) I got hit by a ladder, recovered, and then after 3 years after the recovery my dor barked into my "bad ear". I tried to recover naturally like last time, but it kept getting worse, Sound H started to ache more and more, and after a year my sound tolerance was down to 60 db, and I was getting more and more pain in my ears. Having a 1 year old baby through this didn't help, since I was constantly in setback due to him screaming | Discord | 2025-02-27 | ||||||||
31 | Kai | Pain Hyperacusis (bilateral) Since July 2024 | Unknown | Started in November 2024 but stopped in a couple days due to tinnitus spike; tinnitus went back to baseline | N/A | tinnitus spike | Severe tinnitus, bilateral multi tonal. Started mild, then covid made it severe and noxacusis made it worse | history of trauma, attachment issues, horrible horrible anxiety and probably OCD. Have sore neck and I’m not sure about TMJ or not | Discord | 2025-01-30 | ||||||||
32 | xIMAINZIx (in progress) | Loudness Hyperacusis and some Pain Hyperacusis (sunburn feeling) since 2020 H pain can be in the face along the path of the trigeminal nerve, in the ear or temple as well Occasional MEM thumping | Noise-induced | 10mg-200mg | Started Sept 19th, 2024 | 1/31/25: I've definitely experienced some improvement (about 20-30% since starting), but am unsure whether it's the clomipramine or natural healing. I will stay on the clomipramine for the foreseeable future, anyway. | No effects on tinnitus | 2025-01-30 | ||||||||||
33 | Daniel | From loud music and I had severe nox in one ear, moderate in the other Since March 2024 | Acoustic trauma | 225mg | Started September 14, 2024 | November 14th, 2024: I'm currently 60% better, on 150mg April 2025: Fully healed at 225mg May 2025: Successfully tapered down the drug in one month. Still fully healed | I've had every clomi side effect except increased appetite | Discord | 2025-05-23 | |||||||||
34 | Gregg / G9727 (in progress) | 24/7 occipital and cranial nerve pain ranging and frequency specific hyperacusis (Bilateral) Since Feb 2021 | 10 years of clubbing and music in studios, acoustic shock in my recording studio | 225mg | Started Sept 4, 2024 | before clomi I was in 24/7 burning pain and electricity in my whole head for months the whole skull/scalp. clomipramine has successfully reduced my tinnitus by 70% it has successfully reduced my pain of 90 percent, night bruxism and I almost no longer have TMD. I reckon the improvements is due to an increase in the quality of my sleep. I never slept as deep as on clomipramine. | Mild tinnitus. Also had TT muscle cut but it didn't help | Bruxism, no history of trauma but I did lost my job in the creative industries in London because of COVID and broke up with my girlfriend just after and hyperacusis started 3 months later | Discord | 2025-06-21 | ||||||||
35 | Anonymous User / Sam (in progress) | Loudness H, Pain H, and Tinnitus since March 2024 | Loud bar, acoustic trauma | 25mg-225mg + | Started Sept 1, 2024 | 25mg: 10% improved so far, will continue taking it and increasing the dosage 1/30/25: currently 90% better in one ear, 70% better in the other ear, both loudness and pain improved 2/25/25 @ 225mg: I'm almost fully cured, at about 90%; I can listen to digital sound now with only a small burn; I improved a lot in the week after I stopped wearing ear plugs. I was okay with car horns today. Yesterday putting dishes away didn't hurt either. I don't have loudness H anymore. No problem with plane flying overhead while outdoors with no pro | sleepiness, nausea, tremors, musical hallucinations, anxiety, increased heart rate, increased appetite, dizziness When first started clomi, T "sounded like a circus." Now at 225mg, T is really quiet (went down after about a week on 225mg) NOTE: side effects mostly went away after I got on a high dose | I tried sound therapy before but my right ear was too severe for it. Now I'm trying to continue sound therapy alongside clomi, haven't had much success yet due to setbacks but clomi has improved my tolerance a bit. | 2025-03-01 | |||||||||
36 | Heaven | Pain and loudness hyperacusis, tensor tympani syndrome and tinnitus (not reactive) since August 2023 Burning, aching, feels like acid being poured into the ears. Fullness. Random zaps of stabbing. Always have Delayed pain, only sometimes have immediate pain Throat and jaw pain with ear pain. | Acoustic trauma (air horn) | 25-150mg | Started August 14, 2024 | October 6, 2024 report: Decrease in pain and increase in tolerance of about 10% a week until it stopped at 30% at 100mg and started going back to where she was before she started. Side effects stopped too. December 14, 2024 report: Quit clomi since it was not helping (anymore) and only giving side effects. Those side effects went away with quitting. She does exerience brain zaps which she attributes to quitting cold turkey. | Fatigue, dizziness, nausea, muscle spasms Visual: eye floaters and blurry vision Sexual: decreased libido and taking longer to climax | Tried prednisone, klonopin, and sound therapy before clomi. Feels like sound therapy helped for a while but then it went back to normal Weight and height: 125 lbs and 5’8 | No prior history of other issues | Discord | ||||||||
37 | Cloudsurfer001 | Severe Pain Hyperacusis (burning pain and reactive tinnitus) since Fall 2021 | Cumulative damage from meds, sound injury, possibly also covid vaccine | 25mg-75mg | Started August 2024 | No change to hyperacusis. Made previously-stable tinnitus reactive and catastrophically worse. Discontinued at 50mg. 27th May, 2025 report: I'm attempting to increase again | Tinnitus | Facebook, Discord | 2025-06-01 | |||||||||
38 | DomTheDom-69 (in progress) | Pain and Loudness Hyperacusis since 2023 | Loud construction work | 25mg- | Started mid-July 2024 | Results so far have been great. Its not gone (yet) but i can take more sounds now, and i dont feel as held back as i used to. | The side effects are all that the others mention, the constipation is the only one that truly sucks. | |||||||||||
39 | Gisela (in progress) | Mild Loudness Hyperacusis, Mild/Moderate Noxacusis (burning and stabbing) since September 2023 | Unknown, Pregnancy, stress | 10mg- | Started July 8, 2024 | Switched to amitryptaline because clomipramine side effects were too harsh. | Audiogram shows a hearing loss in 6000 Hz | PTSD, Jaw issues | Discord | |||||||||
40 | Indigo | Loudness and Pain Hyperacusis (burning and delayed) since May 2023 | Acoustic Trauma | 25mg | Started June 28, 2024 | Stopped August 2024 | No change. Stopped taking it because her doctor would not let her go higher than 25mg | Bruxism | Tinnitus and OCD | Tinnitus and OCD | Discord | ||||||||
41 | Anonymous (in progress) | Loudness Hyperacusis since Feb 2024 | Unknown | 6.25-100mg | Started June 1, 2024 | November 19 report: Once I reached 75mg, I saw a huge set of improvements in my sound tolerance and sounds that previously were piercingly loud (flushing toilet, showering, etc) sounded normal again. I felt another set of improvement at the 100mg mark. Might increase to 150mg but plan to stay here at 100+ for several months before tapering off. | Constipation, dry mouth, minor weight gain, some dizzyness upon standing up too quickly. Most of the side effects dissipated after the first several weeks. | Tinnitus; T is unchanged from clomipramine | ||||||||||
42 | Rich (in progress) | Loudness and Pain Hyperacusis since March 2024 | Unknown | 25mg-125mg | Started June 2024 | August 30th report: clomi is definitely working I'd say I'm about 80% improved | Dry mouth, low libido, low blood pressure, raised heart rate | Tried carbamezapine but did not experience any improvement from that. | No impact on VSS which pre-dates the onset of hyperacusis. | Discord | ||||||||
43 | Sgtjsmokey | Loudness and Pain since October 2022 | Unknown | 5mg-10mg | Started June 25, 2024 | Stopped July 10, 2024 | No change. Quit due to worsening tinnitus. Feels that clomipramine made his tinnitus reactive | Tinnitus spike, slight spike in VSS | My ear troubles started in October 2022. At first it was severe T woth what I think is TTTS, then 6 months in I got VSS, then 13 months in I got H with daily migraines. In this time I would have the odd stabbing pain in my ears that never lingered. Then slowly after H I got more and more ear pain till recently I got lingering burning aching and sometimes a stab. | I've been agoraphobic for 10 years and have been mainly housebound for 8 of those years I have OCD, ADHD, Autism I've been on 36 different meds before all this started some for a couple of years some a couple days Atm I supplment with liquid magnesium, zinc, alpha acid, rosemary powder, cilantro, Vit D, I'm also diabetic And I take omeprazole for GERD And antihistamines all year round as I have allergies | Discord | ||||||||
44 | Obiwan3926 (in progress) | Severe Pain Hyperacusis since 2011 | Barotrauma | 5mg-187.5mg | Started June 22, 2024 | August 7th Report: began seeing significant improvements at 40mg. For example, can now flush toilet (70db) without any pain without wearing ear protection. August 20th report: Jumping today from 50 to 60mg. It helps me but I am still fragile. Got blasted today in the street by some workers throwing metal junk on the pavement. Was able to talk normally without pain (almost) and shower with plugs without pain. I have good hopes that it will get better with increasing doses. March 31, 2025: Today I went to have lunch on a noisy terrace with colleagues and had 8 hours of meetings at work without plugs. No issues. | Minor dizziness, sedation, musical hallucination starting at 30mg Got significantly worse before better while on the lower doses of clomi | Also has Botox injections into TVP by Dr. Boedts Tried Zoloft and Lexapro (among many other meds) in the past with zero effect on hyperacusis | Discord | |||||||||
45 | Kinda Cryptocal (in progress) | Loudness and Pain (pain occassionally; stabbing) since 2022 | Acoustic trauma (gun shots) | 5mg-150mg | Started May 29, 2024 | Helping loudness H and pain H so far; seems to work best when clomi is making him feel more sedated. Has helped red ear episodes triggered by sound (an autonomic symptom) | Jerks | Discord | 2025-07-01 | |||||||||
46 | Tatertodd31 / 2001 Honda Odyssey (in progress) | Loudness and Pain Hyperacusis since June 2021 | Noise-Induced and vaccine | 25mg-150mg | Started May 14, 2024 | October 21 report: I am feeling impatient. I have not used digital audio in almost 2 years. Nearing the end of week 5 on 150mg of clomi and I have felt no difference | Tinnitus spike (lasted 7 days) and nausea | Has VSS | ||||||||||
47 | John D (in progress) | Loudness H and Pain H since August 2023 | Likely acoustic trauma (metal concert) | 25mg- | Started May 10th 2024 | Doing much better now. Able to hang out with small groups of friends and go to work at a retail store with occasional use of plugs. Has not tried loud restaurants yet. | During the first two weeks I had severe lethargy, stomach aches and just a general feeling of sickness. Definitely a rough transition but after that the only long lasting symptoms have been urinary frequency. I still pee much more frequently than I did before I started taking Clomi. Besides that no other symptoms. | Tinnitus has not been affected by clomi. Had some natural improvement prior to clomi but improvements became much more rapid after starting clomi. The pain was a mix of burning, stabbing and stinging. I felt the pain in my ear, behind my ear, and on my face. It was immediate with sound. Nox was originally relatively severe. I could not leave the house without ear protection and was not able to withstand digital audio. Whenever I listened to digital audio a burning sensation would start forming in the back of my ears. I could talk at moderate volume but not for a very long time. Stuff like running water and opening doors was hard. I couldn't open a door without ear protection for months. Stuff like glass plates and metal silverware was hard. Airplanes caused me a lot of discomfort and I would put on earmuffs whenever one flew overhead. Overall I was homebound for about 7-9 months. | I had a series of severe ear infections as a kid that caused moderate hearing loss. I had tinnitus as well. I also had a deviated septum that caused chronic sinitus until I had a septoplasty to fix it. As a result I have a weak jaw and abnormally long nose.I have ADHD. | |||||||||
48 | Sagar (in progress) | Loudness Hyperacusis | Acoustic trauma | 12.5mg-75mg | Started April 26, 2024 | Possible small improvements (5%-10%) | Dry mouth, constipation, dizziness, visual disturbance, sedation | No improvement from CBT and could not tolerate sound therapy | ||||||||||
49 | Weyms | Pain Hyperacusis since 2021 | Acoustic trauma over time, Covid, TMJ | 12.5mg-175mg | Started April 10, 2024 | Stopped August 2024 | May 19, 2024: 90% improvement. Bumped up to 150mg recently and felt another increase in sound tolerance. "I am pretty convinced that I'll never feel pain anymore now that I've hit 150mg." Stayed at 175mg for about a month. Began tapering off clomi end of July (doing a six week taper off). | Experienced side effects for first five days then resolved | Had the Silverstein Institute surgery (the updated surgery: reinforce the stapes and oval/round window & 2 layers of fascia covering the eardrum) done on March 29, 2024 performed by Dr. Nayak. Results: "I wore protection 24/7 for 3 years and have not worn protection for a month now and haven't had any pain or discomfort in my operated ear. I had burning pain hyperacusis and LDL's in the 60's pre-surgery and it helped tremendously. I was able to go to outside restaurants and even a grocery store before I ever started taking Clomi so the surgery definitively worked bigtime for me." Getting other ear done at Silverstein on July 12, 2024. | No tinnitus | Discord | ||||||||
50 | Alone-Palpitation761 (in-progress) | Loudness Hyperacusis since 2022 | Noise-induced | 25-250mg | Started April 5, 2024 | Possible improvements. Believed time of recovery from setbacks is faster on clomipramine. Also loudness hyperacusis is less bothersome. October 16th report: I’m doing better now, I managed to recover about one db of tolerance a week and I’m able to drive and eat most food again. All of the side effects went away and I’ve also started tapering. I’m down to 150 mg a day. I wouldn’t say I’m recovered but I’m definitely in the right direction. I still use hearing protection for day-to-day activities. If I continue improving at this rate, I’ll be back to normal in about a year. | Dry mouth, constipation, sexual issues/changes, drowsiness, improved depression, improved sleep, improved ocd, tinnitus less bothersome | Has tried magnesium, gabapentin, lisinoprol, and baclocen without success | ||||||||||
51 | Brody (in-Progress) | Pain Hyperacusis since 2022 | Noise-Induced | 25mg-250mg | Started March 18, 2024 | Sept 13th report: I’ve been having a good amount of success with clomipramine. I’m at 150mg and I’ve seen improvement in many areas. My pain threshold has improved to some extent so I can hear louder sounds without feeling pain. More significantly though my pain level has dropped by about 80% and and when I am in pain is goes away much faster than it used too. I haven’t been in pain for more than 24 hours in the last month whereas before I was in pain almost constantly. Oct 19th: still seeing improvements. Bumped up to 200mg. January 28, 2025: I've been holding off writing an update about my case, but for those who are interested, I've been having remarkable success on clomipramine, especially after getting to 200mg. Although it's hard to estimate how much I've improved, I'd say at least 80%. I have spent over a month with no ear protection at all in my house, and have had zero pain, except a minor amount after watching a full movie. Currently, I’m able to have no pain around any natural sounds that are 60-70 decibels. I haven’t tested higher but I’m confident that I’ll be fine with at least low amounts of it. I’m in one of the coldest parts of Canada, so I haven’t been outside much but I am also confident that I’ll be fine when I do. Hopefully, the next update will say I’m 90% better. Right now I’m going to continue slowly desensitizing and being patient, but my doctor has offered to let me go up to 250mg of clomipramine so I may do that if I feel my improvement has stalled. Biggest improvements I had were after going to 100, 150, and 200mg. | Drowsiness, sexual issues/changes, one week after reaching 150mg experienced "musical hallucinations" which is a rare but known side effect. Reduced to 100mg and the musical ear syndrome went away. Hand termours at 250mg | Increased to 150mg on May 30, 2024. Has since increased to 250mg (March 2025). | Discord | 2025-06-21 | ||||||||
52 | Pbb1235 (in-progress) | Pain and Loudness Hyperacusis since 2012 | Noise-induced (gunshot) | 25mg-250mg | Started March 2024 | Substantial improvement of pain and setback likelihood. Moderate improvement in noise sensitivity. September 13th Report: 80% improvement. March 20, 2025 update: I went up to 250 mg for a while, and dropped back to 225 mg because I started getting an elevated pulse. I am probably getting about 90% relief. I still have some sensations of loudness around obnoxiously loud things. Setbacks are rare and don't last long (so far) | Dry mouth, constipation, sweating, tremor, sexual changes/issues | Sound and music therapy helped to some extent early on. Also, he saw the most improvement from clomipramine once he reached 200mg 75 mg Nortriptyline did not help | Has mild tinnitus, which has not been significantly impacted by clomipramine. Elevated pulse at 250mg | Reddit, Discord | ||||||||
53 | Jyggrasil / Kyle (In-progress) | Loudness and Pain Hyperacusis (Aching & Burning Facial Pain) since September 2023 | Noise-Induced | 25mg-200mg | Started January 24, 2024 | Reached 200mg on June 12, 2024 | August 31, 2024 update: I would say my life is 100% back to normal. I don’t have any ear issues in my daily life, and I’m able to forget about all that stuff for the most part. I still struggle with a bit of PTSD from the whole experience, but I’m trying to work through it as best as I can. Overall, life is good and I’m so grateful to still be alive after this whole nightmare. | Only minor sexual issues | Saw biggest set of improvement after increase to 150mg. June 14, 2024 report: Last week I was exposed to the loudest sound I’ve experienced while dealing with H. Some guy on a motorcycle came roaring past me out of nowhere and completely blasted my ears (I was not wearing any ear protection). Definitely upwards of 100+ decibels. Prior to clomi, this would have absolutely ruined me. I decided to give it a week a bit and see, and I’m happy to report I’ve experienced no setback or increase of pain. | Also tried lyrica, amitriptyline, codeine, and some other painkillers previously. Nothing else helped except for clomipramine | Discord | ||||||||
54 | Lux (in-progress) | Loudness and Pain Hyperacusis since December 2023 | Unknown but possible sound trauma | 25mg-175mg | Started in January 2024 | Possibly slight improvements for loudness | Dry mouth, constipation, sexual issues/changes, possible eye issues, musical halucinations | Already has severe visual snow syndrome which could explain side effects | Discord | |||||||||
55 | Almondiga (in-progress) | Loudness and Pain Hyperacusis (Burning & Stabbing) Since November 2022 | Unknown | 25-225mg | Started Dec 27, 2023 | August 20th Report: I've been on 185mg for 8 months now. After 6 months on clomi I now live almonst a normal life. I only use ear pro at my work and at very loud places, like cinemas. I can listen digital sounds with no problema, before clomi it was imposible. Up until 3 days ago, I was feeling really good - about 80% recovered. I could go anywhere without earplugs, like the supermarket, noisy restaurants, or busy streets, and I was pain-free. Unfortunately, I had a setback after a 10-hour car ride without earplugs. The pain in my left ear is back, and my tolerance has decreased a lot. I hadn't had a relapse in months. Clomi is working though. I hope to go back to how I was. Sept 3rd Report: The last time I wrote was during a relapse, but after 2 or 3 days I was feeling fine again. Relapses have been much milder since I've been taking clomipramine. Right now I'm taking 225mg, and I'll stay at that dose for a while. I don't have any pain right now. For something to bother my ear, it would have to be a very loud and sudden sound. During my vacation, I only used earplugs for a 9-hour car ride. The rest of the time I went everywhere without earplugs and had no problems. I can live a relatively normal life. | The first month was very tough, lots of anxiety, depression, chills, insomnia. Over time, side effects resolved and now only has anorgasmia, some weight gain, and a bit of generalized fatigue | Had loudness & pain for 1.5 years before starting clomipramine (pain set in a few weeks after loudness). In that 1.5 years, saw 20-30% improvement with natural recovery but had setbacks. Started clomipramine in December 2023. Been at 150mg for two months. Considering increasing to 200mg. | Discord | |||||||||
56 | SoniCarvalho | Mostly Loudness Hyperacusis but some Pain | Unknown | 25mg-150mg | 1 year and 6 months | No change | Improved sleep | N/A | ||||||||||
57 | life_gave_me_Lemonz (in-progress) | Hyperacusis | Unknown | 25mg-150mg | 4 months | No change | Unknown | Is on several other medications so only stayed at 150mg for a couple of weeks before going back to 75mg when no improvement was observed | ||||||||||
58 | Andrew | Loudness and Pain Hyperacusis (Burning) since 2022 | Unknown | 25mg-200mg | Started October 25, 2023. Was at or above 150mg for 5 months. Began tapering down May 2024 and weaned off completely by June. | 65% improvement. Feels his improvement plateaued at the 200mg mark. | Tinnitus spikes and other temporary side effects. Possible tinnitus improvements long term | Saw improvements weeks after increase to 150mg. Other treatments: Nervus Intermedius section on Feb 29, 2024. Ossicles disarticulation on May 1, 2024 | History of boat and car racing. Also has TTTS and mild visual snow syndrome (since 2019) | Discord, Facebook | ||||||||
59 | Gene | Loudness and Pain Hyperacusis (Burning) | Possibly Covid vaccine or mild noise trauma. Covid vax gave him reactive tinnitus, but fullness + burning started after his phone was up to his ear and a loud sound played. | Increased slowly to 150mg; stayed there for 8 months; decreased slowly and at 25mg as of March 2025 (remains 100% recovered); will stop in 3 months | 10 months over 2023-2024. As of June 2024, plans to take it for two more months in order to taper off slowly | Full recovery | Constipation | Had SPG blocks and ablation around the time he started taking clomipramine | Facebook Hyperacusis Surgery Group | 2025-03-08 | ||||||||
60 | Davitibus | Loudness & Pain Hyperacusis (aching & stabbing) since 2018 | Unknown; likely stress induced | 0.8mg-150mg | Oct. 2021: 0.8mg - taking many small steps --> Dec. 2021: 40mg --> mid Feb. '22: 150mg --> held at 150mg for about a month --> went down to zero in about 6 weeks | No change | Sleeping problems, small muscle spasms, increase in appetite | Discord | ||||||||||
61 | Wiektor | Loudness Hyperacusis | Likely noise-induced. Possibly from mirtazapine | 25mg-100mg | Started July 2023; Stopped May 2024 | Full recovery | Bothersome side effects for three weeks but improved after that. Only some dry mouth and constipation. Tinnitus is 40% better and depression has improved and sexual issues returned to normal. MAY 11, 2024 UPDATE: successfully stopped taking Clomipramine. The third day after stopping (7mg/day in that last phase), I got some brain/body zaps/spasms that were funny and weird. I also had a few moderate mood swings for five days. Now am back to 100% normal, and I don't have zaps or mood swings anymore. | Had loudness hyperacusis for three months before trying clomipramine. Tinnitus has also become a static/white noise most of the time rather than metallic/high frequency. Also still takes Taurine (1 g), Magnesium (400 mg), Ginkgo Biloba (120 mg equivalent), and Vitamin B1 (100 mg) daily. | Tinnitustalk | |||||||||
62 | Frida | Loudness Hyperacusis circa 2009 | Falling down stairs | 25mg-200mg | Three years | Full recovery | Dizziness, dry mouth, sweating, constipation, fatigue, and sexual issues | Saw improvements primarily after increase to 200mg | German Support Forum and Sanego Drug Review Site | |||||||||
63 | Pfifferlinga | Hyperacusis | Unknown | 60mg | Unknown | Full recovery | Experienced side effects but not specific. | N/A | German Support Forum | |||||||||
64 | Kane68 / Mark | Loudness Hyperacusis circa 2015 | remains cured as of 2024 | Noise-Induced | Increased to 90mg | 9 months | Full recovery | Unknown | Took clomipramine in 2015. As of 2024 his hyperacusis has not returned (confirmed via email) | German Support Forum and Sanego Drug Review Site | |||||||||
65 | Lila | Hyperacusis circa 2015 | Unknown | Increased to 100mg | 6 months (Started in December 2015) | 80% improvement | Minor side effects | Took clomipramine in 2015 / 2016 | German Support Forum | |||||||||
66 | Elisa | Hyperacusis circa 2017 | Unknown | Unknown | Unknown | Improvement | Unknown | Took clomipramine in 2017 | German Support Forum | |||||||||
67 | Jerimaine82 / Christoph | Hyperacusis circa 2017 | Unknown | 37.5mg-112.5mg | 6 months | Substantial improvement | First week depressed, then ravenous appetite for candy, lust for sex decreased, hard to reach climax. | Very severe case. Was in constant ear protection for two years before taking clomipramine. Tried a similar medication before clomipramine based on advice from his doctor which did not improve him. Took clomipramine for 6 months in 2017 and then again in 2019. | German Support Forum | |||||||||
68 | MatthijisDJ | Hyperacusis | Unknown | Unknown | Unknown | Full recovery | Unknown | Took Mirtazaline at the same time. Possible tinnitus improvements as well | German Support Forum | |||||||||
69 | Simba10 / Gotthard | Loudness & Pain circa 2018 | remains cured as of 2024 | Unknown | Increased to 125mg | 1 year. 3 months at 125mg | Full recovery | Minor dry mouth, appetite gain, and sweating. Side effects gone after quitting the medication | As of 2024 his hyperacusis has not returned (confirmed via email) | German Support Forum and Sanego Drug Review Site | |||||||||
70 | Trafalgar D / FatBananaBread | Loudness and Pain Hyperacusis (stabbing pain at normal and high sounds) since September 2021 | remains cured as of 2024 | Covid-19 Vaccine (Moderna) | 37.5mg-150mg | Started May 16, 2022 | tapered off August 2023 (15 months total) | Full recovery | Dry mouth when working out. Clomipramine has solved my problems with insomnia. Lower sex drive | Very severe case that saw substantial improvement. He collected all the stories of clomipramine from Germany featured in this spreadsheet. Had hyperacusis for 8-9 months before starting Clomipramine. As of 2024 he remains hyperacusis free. | Severe reactive tinnitus, and TTTS. Both unaffected by clomipramine. | Tinnitustalk | ||||||||
71 | Unnamed German lady | Hyperacusis | Unknown | Unknown | 3 months | Significant improvements | Constipation | Abruptly stopped taking the drug because of constipation. Her hyperacusis returned then. There is no source for the experience. It was listed on a German website | German Website Testimonial | |||||||||
72 | I3anback | Hyperacusis | Unknown | 150mg | 1.5 - 2 months (started September 2019) | No change | Possible tinnitus improvements | He said he would take it for 1 year but has not reported back any results after using it for 2 months | Tinnitustalk and German Support Group | |||||||||
73 | Pitseleh | Hyperacusis | Unknown | 25mg - 50mg | 3 Weeks | No change (quit due to side effects) | Tinnitus possibly permanently worsened and regular side effects (dry mouth, fatigue, etc.) | N/A | Tinnitustalk | |||||||||
74 | Justin Andreas | Pain Hyperacusis (stabbing) | Noise-Induced | 25mg-200mg | A few months | No change | Possibly some minor side effects (dry mouth and sexual issues) | Took large doses of Lyceum and gabapentin at the same time as clomipramine and did not gradually increase dosages | Tinnitustalk | |||||||||
75 | Voleterra | Pain Hyperacusis | Noise-induced | 10mg-20mg | 1 week | Possible worsening | Lots of bad side effects. Felt sick and couldn't sleep. Possibly made tinnitus and hyperacusis worse | Was planning to start the drug again after a week break but no further information was posted | Tinnitustalk | |||||||||
76 | StoneInFocus | Loudness and Pain Hyperacusis | Unknown | 25mg | 2 days | No change (quit due to side effects) | Dry mouth, felt sick, and tinnitus spike that returned to normal after quitting) | N/A | Tinnitustalk | |||||||||
77 | Hopeforall96 | Hyperacusis | Unknown | Unknown | A few days (November 2023) | No change (quit due to side effects) | Tinnitus spike | N/A | Tinnitustalk | |||||||||
78 | Morgoth51 / Paul | Pain Hyperacusis (Burning in ear that could spread to jaw, neck and eye) | Repeated acoustic trauma incidents | Increased to 150mg | A few months | Full recovery. He had successfully tapered off the drug but in January 2024 experienced a major setback and started back on it for a second time. Started at 10mg and worked up to 100mg and has been at 100mg from Jan-April and pain is gone 80-90%. | Dry mouth, bad sweating, sexual issues, anticholingeric issues. Says as pain hyperacusis improved, it morphed into loudness which they've been dealing with well | Had hyperacusis for six months before starting on Clomipramine in 2023. | Tinnitustalk | |||||||||
79 | Rania | Loudness Hyperacusis | Possible ototoxicity or a mental health issue | Unknown | Unknown | Full recovery | Unknwon | After recovering from loudness through clomipramine she suffered from a possible acoustic trauma and then developed worsen symptoms including nox. She was thinking about trying clomipramine again but nothing has been posted since. English was hard to understand and highly unorganized | Pain Hyperacusis Facebook Group | |||||||||
80 | Matthew | Pain Hyperacusis (Limited info on his case) | Unknown | 75mg | Unknown | Significant improvements | Unknwon | Takes gabapentin and hydrocodone with it. | Hyperacusis Support Facebook Group | |||||||||
81 | Kathy | Loudness Hyperacusis | Unknown | Worsening | A couple of days | No change (quit due to side effects) | Tinnitus spiked and other side effects | Original source seems to be deleted | Hyperacusis Support Facebook Group | |||||||||
82 | Xolith | Loudness and Pain Hyperacusis | Noise-Induced | Unknown | A few days | No change (quit due to side effects) | Tinnitus spike, insomnia, hot, felt like a zombie | N/A | Discord | |||||||||
83 | Kingers | Loudness and Pain Hyperacusis | Noise-Induced | 20mg | 5 Days | No change (quit due to side effects) | Tinnitus spiked (temporary, went back to baseline), sweating, insomnia, brain fog, changes to taste and smell | After the first couple of dosages he thought he experience positive results but by the end he was experiencing many side effects; may consider trying again, starting lower | Discord | |||||||||
84 | TallMonk825 | Loudness and minor Pain Hyperacusis | Unknown | 50mg | 1 month | Full Recovery | Tinnitus 70% gone, Constipation, Sexual chanhes#Issues | Worked on decressing his stress and anxiety at the same time | ||||||||||
85 | Zvle | Pain Hyperacusis | Unknown | Unknown | Unknown | No change (quit due to side effects) | Caused IBS (possibility permanent) | N/A | ||||||||||
86 | Bonio094 | Loudness Hyperacusis | Noise-Induced | 34.5mg - 150mg | Unknown | Significant improvements | Constipation | N/A | ||||||||||
87 | X_Fuggedaboudid | Hyperacusis | Unknown | Increased to 50mg | Unknown | No change (quit due to side effects) | Says it turned him into a zombie | Has eagle syndrome | ||||||||||
88 | MountMite | Hyperacusis | Possible noise-induced or autism related | 25mg-75mg inconsistently | 4 years | No change | Unknown | Saw improvements with his hyperacusis but believed they were due to other factors and not the clomipramine | ||||||||||
89 | Parker Exists | Hyperacusis | Unknown | 25mg - unknown | Unknown | No change | Unknown | Resolved hyperacusis through fixing TMJ | ||||||||||
90 | AaronRKC | Hyperacuiss | Noise-Induced | Unknown | Unknown | No change | Unknown | N/A | ||||||||||
91 | Unknown person (data gained through secondary source) | Loudness Hyperacusis | Unknown | 25mg | 1 week | No change to loudness hyperacusis but developed pain hyperacusis (quit due to side effects) | Thinks the medication might have caused pain hyperacusis in left ear | A tinnitustalk user quoted this person's experience but there is no direct source to verify | Unknown | |||||||||
92 | Vonhye | Loudness and Pain Hyperacusis | Unknown | 12.5mg - 25mg | A few days | No change | Severe worsening of Visual Snow Syndrome (Could no longer use screens) - after one year able to work and use screens again | Near-sighted and predisposed to glucoma | Discord | |||||||||
93 | Techno_Psychsosis | Hyperacusis | Unknown | 25mg | 1 week | No change (quit due to side effects) | Insomnia | N/A | ||||||||||
94 | ||||||||||||||||||
95 | ||||||||||||||||||
96 | ||||||||||||||||||
97 | ||||||||||||||||||