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TableDescription
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1. Sample Clinical DemographicsGeneral sample demographics
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2. Sample Cell TypesCell type distribution per sample
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3. Cancer cell annotationCancer cell annoations for all epitheial cells
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4. Sample Analyses
Table of all analysis done and sample inclusion
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Column Name Descriptions for Table 1. Sample Clinical Demographics
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Sample Nameunique name of sample
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Patient IDunique patient identifier
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Age at biopsy (years)age of patient at time of biopsy
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Gendergender of patient
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Racerace of patient
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Smoking Hx
smoking history of patient, categorized as never or former
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Histolgybiopsy histology classification
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Oncogenic Driver Mutation
clinically targeted mutated mutation, as determined by clincal testing
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Stage at Dxstage of cancer at diagnosis
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Pathology Review
clincal patholgy review, classified as positive, normal or no evaluation
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Biopsy Type
biopsy aquistion method, generally categorized as thoracentesis, resection, core or bronchoscopy
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Biopsy Sitebiopsy aquistion site
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Primary/Metastatic
biopsy aquistion site classification as either primary or metastatic location
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Treatement Timepoint
sample response to treatment at time of biopsy
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Treatment start to tissue acquisition (days)
number of days from the time of start of current treatment
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Treatment Hxprior treatments
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Line of Therapynumber of lines of therapy
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Treatment
reported current treatment for RD and PD treatment timepoints, alternatively for the TN treatment timepoint this is the treatment they will start.
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Column Name Descriptions for Table 2. Sample Cell Types
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Sample Nameunique name of sample
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Patient IDunique patient indentifier
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AT1Aveolar type 1
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AT2Aveolar type 2
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B-cells-MMemory B cells
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B-cells-PBPlasmablast B cells
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Basal cellBasal cells
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Ciliated cellCilated cells
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Club cellClub cells
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DendriticDendritic cells
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EndothelialEndothelial cells
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FibroblastFibroblast cells
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HepatocyteHepatocyte cells
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IonocyteIonocyte cells
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Mast-cellsMast cells
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MelanocytesMelanocytes
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MF-Monocytes
Macrophages and Monocytes are grouped together
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Neuroendocrine cellNeuroendocrine cells
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NeutrophilsNeutrophils
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pDCsPlasmacytoid dendritic cells
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T-cellsT cells
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Cancer cellCancer cells (as determined by inferCNV)
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Unknown
Unknown cells from general clustering of all cells passing QC
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Unknown stroma1
Unknown stroma fround in subclustering of epithelial cells
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Unknown stroma2
Unknown stroma fround in subclustering of epithelial cells
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Unknown stroma3
Unknown stroma fround in subclustering of epithelial cells
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Unknown stroma4
Unknown stroma fround in subclustering of epithelial cells
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Unknown stroma5
Unknown stroma fround in subclustering of epithelial cells
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Column Name Descriptions for Table 3. Cancer cell Annotation
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cell_idcell name
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sample_nameunique name of sample
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patient_idunique patient identifier
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inferCNV_annotationannotaion of cancer or non-cancer cell
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Column Name Descriptions for Table 4. Sample Analyses
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Sample Nameunique name of sample
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Patient IDunique patient indentifier
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Immune Fractional Changes
list of samples included in finding fractional changes among treatment timepoints (code IM02)
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Macrophage Analysis
list of samples included in macrophage analysis (code IM03)
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Tcell Analysis
list of samples included in t-cell analysis (code IM04)
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NonImmune Analysis
list of samples included in non-immune cell analysis (code NI01)
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Epitheilal Analysis
list of samples included in epithelial cell only anlaysis and inferCNV (code NI02 and NI03)
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Cancer Cell Analysis
list of samples included in cancer cell compairisons among treatment timepoints (code NI04 and NI08)
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TH226 Longitudial Analysis
list of samples included in TH226 longitudial cancer cell analysis (code NI07)
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EGFR and ALK Cancer Cell Analysis
list of samples included in EGFR and ALK cancer cell only signature anlaysis (code NI16)
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PD Signauture Analysis
list of samples included in PD treatment timepoint cancer cell signature analysis (code NI17)
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