.

NNI (generic name) of products on NCI's Alpha List of cancer drugs
Orignator brand nameOriginator companyParent Company
Parent origin
FDA Type
1st BLA/NDA numberFDA chemical type codeYear 1st approvalDate 1st approvalS or P (NDA only)Competitors (July 2011) - need to double check BLAs
Number orphan designationsDate of 1st orphan designation1st orphan designation before 1st approval?Number FDA marketing approvals orphan indicationsNIH Report Grants (22 July 2011)Number of Patents in NIH Report database (22 July 2011)
WHO essential medicines list - 17th ed, March 2011WHO essential medicines list - 12th ed, April 2002Original Exp.
Date
Extended Expiration Datedays extended

.

1Abiraterone AcetateZytigaCentocor OrthoJohnson and Johnson USNDA202379120112011/4/28P1110

.

2VandetanibVandetanibIPR PHARMS INCAstraZeneca UKNDA 022405120112011/4/6P1110/21/2005TRUE1121

.

3IpilimumabYervoyBristol Myers SquibbBristol Myers Squibb USBLA12537720112011/3/25116/3/2004TRUE160

.

4Eribulin MesylateHalavenEisaiEisai JPNDA 201532120102010/11/15P100

.

5CabazitaxelJevtana KitSanofi Aventis USSanofi FRNDA 201023120102010/6/17P110

.

6DenosumabProlia (Xgeva)AmgenAmgen USBLA12532020102010/6/11112/20/2010FALSE010

.

7Sipuleucel-TProvengeDendreon CorporationDendreon USBLA12519720102010/4/29100

.

8RomidepsinIstodaxCelgeneCelgene USNDA 022393120092009/11/5S119/30/2004TRUE11902009.07.062011.07.06730

.

9OfatumumabArzerraGlaxo GroupGlaxoSmithKline UKBLAP12532620092009/10/26113/10/2009TRUE110

.

10Pazopanib HydrochlorideVotrientGlaxosmithklineGlaxoSmithKline UKNDA 022465120092009/10/19no entry161

.

11Recombinant HPV Bivalent VaccineCeravixGlaxoSmithKline Biologicals
GlaxoSmithKline UKBLA12525920092009/10/161108151

.

12PralatrexateFolotynAllosAllos
USNDA 022468120092009/9/24P147/20/2006TRUE100

.

13EverolimusAfinitorNovartisNovartis CHNDA 022334120092009/3/30P142/14/2008TRUE1382

.

14DegarelixFirmagonFerringFerring CHNDA 022201120082008/12/24S100

.

15PlerixaforMozobilGenzymeSanofi FRNDA 022311120082008/12/15P117/10/2003TRUE192

.

16Eltrombopag OlaminePromactaGlaxosmithklineGlaxoSmithKline UKNDA 022291120082008/11/20P150

.

17RomiplostimNplateAmgenAmgen USBLA12526820082008/8/221110/31/200740

.

18Bendamustine HydrochlorideTreandaCephalonCephalon USNDA 022249120082008/3/20P118/17/2007TRUE110

.

19NilotinibTasignaNovartisNovartis CHNDA 022068120072007/10/29S124/27/2006TRUE1163

.

20IxabepiloneIxempraBristol Myers SquibbBristol Myers Squibb USNDA 022065120072007/10/16P1393

.

21TemsirolimusToriselWyeth Pharms IncGlaxoSmithKline UKNDA 022088120072007/5/30P1112/16/2004TRUE1378

.

22Lapatinib DitosylateTykerbSmithkline BeechamGlaxoSmithKline UKNDA 022059120072007/3/13P115/29/2009FALSE03842019.01.082020.09.29630

.

23VorinostatZolinzaMerckMerck USNDA 021991120062006/10/6P136/12/2003TRUE121745

.

24PanitumumabVectibixAmgenAmgen USBLA12514720062006/9/2711632017.05.052020.04.081069

.

25DasatinibSprycelBristol Myers SquibbBristol Myers Squibb USNDA 021986120062006/6/28P1211/18/2005TRUE211992020.04.132020.06.2876

.

26Recombinant HPV Quadrivalent VaccineGardasilMerckMerck USBLAP12512620062006/6/8134442015.10.132019.01.241199

.

27DecitabineDacogenEisaiEisai JPNDA 021790120062006/5/2S143/8/1999121034

.

28Sunitinib MalateSutentCPPI CVPfizer USNDA 021938120062006/1/26P1633

.

29LenalidomideRevlimidCelgeneCelgene USNDA 021880120052005/12/27P159/20/2001TRUE211382016.06.242019.10.041197

.

30Sorafenib TosylateNexavarBayerBayer DENDA 021923120052005/12/20P114916

.

31NelarabineArranonSmithkline BeechamGlaxoSmithKline UKNDA 021877120052005/10/28P129/2/1999TRUE11152012.06.132017.06.131826

.

32ClofarabineClolarGenzymeSanofi FRNDA 021673120042004/12/28P122/7/2002TRUE169152014.08.262018.01.141237

.

33PaliferminKepivanceAmgenAmgen USBLA12510320042004/12/1511415

.

34Erlotinib HydrochlorideTarcevaOSI PharmsAstellas JPNDA 021743120042004/11/18P117/18/2003TRUE0484362015.06.062018.11.081251

.

35AzacitidineVidazaCelgeneCelgene USNDA 050794120042004/5/19P1212/3/2001TRUE153278

.

36BevacizumabAvastinGenentechRoche CHBLA12508520042004/2/261811/6/2003TRUE15541012017.04.252018.02.26307

.

37CetuximabErbituxImcloneEli Lilly USBLA12508420042004/2/12127/3/2000TRUE129456

.

38Pemetrexed DisodiumAlimtaLillyEli Lilly USNDA021462120042004/2/4P118/28/2001TRUE160102011.09.062016.07.241783

.

39Palonosetron HydrochlorideAloxiHelsinnHelsinn CHNDA 021372120032003/7/25S1002010.04.132015.04.131826

.

40Tositumomab (I 131 Iodine Tositumomab)BexxarSmithklineGlaxoSmithKline UKBLA12501120032003/6/27115/16/1994TRUE013852

.

41BortezomibVelcadeMillenniumTakeda JPNDA 021602120032003/5/13P141/15/2003TRUE1519332014.10.282017.05.03918

.

42GefitinibIressaAstrazenecaAstraZeneca UKNDA 021399120032003/5/5P1474362016.04.262017.05.05374

.

43AprepitantEmendMerckMerck USNDA 021549120032003/3/27P16442012.06.292015.04.171022

.

44OxaliplatinEloxatinSanofi AventisSanofi FRNDA 021492120022002/8/9P8110/6/1992TRUE0299412013.04.072016.08.091220

.

45RasburicaseElitekSanofi SynthelaboSanofi FRBLA10394620022002/7/121110/11/2000TRUE1502012.01.172016.07.121638

.

46FulvestrantFaslodexAstrazenecaAstraZeneca UKNDA 021344120022002/4/25S1823662004.10.012007.12.111166

.

47Ibritumomab TiuxetanZevalinSpectrumSpectrum USBLA12501920022002/2/19119/6/1994TRUE166232015.07.072016.02.19227

.

48Zoledronic Acid (aka zoledronate)ZometaNovartisNovartis CHNDA 021223120012001/8/20P118/18/2000TRUE191422007.11.132012.09.021755

.

49Imatinib MesylateGleevecNovartisNovartis CHNDA 021335120012001/5/10P1611/1/2001FALSE6680772013.05.282015.01.04586

.

50AlemtuzumabCampthIlexIlexUSBLA10394820012001/5/71110/20/1997TRUE18514

.

51Arsenic TrioxideTrisenoxCephalonCephalon USNDA 021248120002000/9/25P173/3/1998TRUE117212

.

52Gemtuzumab OzogamicinMylotargWyeth Pharms IncPfizer USNDA 021174120002000/5/17P1180

.

53BexaroteneTaragretinEisaiEisai JPNDA 021055119991999/12/29P116/18/1999TRUE15114

.

54Aminolevulinic AcidLevulanDUSADUSA USNDA 020965119991999/12/3S113/20/2007FALSE024622

.

55ExemestaneAromasinPharmacia and UpjohnPfizer USNDA 020753119991999/10/21S219/19/1991TRUE14802006.07.072011.04.011729

.

56Epirubicin HydrochlorideEllencePfizerPfizer USNDA 050778119991999/9/15P144425

.

57TemozolomideTemodarScheringBayer DENDA 021029119991999/8/11P2410/5/1998TRUE2683612010.11.092013.08.111006

.

58Denileukin DiftitoxOntakSeragenLigand USBLA10376719991999/2/5138/21/1996TRUE1599

.

59TrastuzumabHerceptinGenetechRoche CHBLA10379219981998/9/251212/14/1999FALSE170883

.

60ThalidomideThalomidCelgeneCelgene USNDA 020785119981998/7/16P1159/19/1988TRUE286680

.

61CapecitabineXelodaHoffmann La RocheRoche CHNDA 020896119981998/4/30P1124212008.11.082011.01.13796

.

62TalcSclerosolBryanBryan USNDA020587119971997/12/24P239/18/1995TRUE1910

.

63Raloxifene HydrochlorideEvistaLilyEli Lilly USNDA 020815119971997/12/9P118/20/2010FALSE064853

.

64RituximabRituxanGenetechRoche CHBLAP10370519971997/11/261 (2)46/13/1994TRUE3823107

.

65LetrozoleFemaraNovartisNovartis CHNDA 020726119971997/7/25S14156152007.12.182011.06.031263

.

66ToremifeneFarestonGTX Inc
GTX USNDA 020497119971997/5/29S129/19/1991TRUE14352004.09.292009.09.291826

.

67ImiquimodAldaraGracewayGraceway USNDA 020723119971997/2/27S6128342004.08.252009.08.251826

.

68Irinotecan HydrochlorideCamptosarPfizerPfizer USNDA 020571119961996/6/14P17609582004.07.052007.08.201141

.

69Topotecan HydrochlorideHycamtinGlaxoSmithKlineGlaxoSmithKline UKNDA 020671119961996/5/28P10110/30/2008FALSE08031362008.04.022010.05.28786

.

70Gemcitabine HydrochlorideGemzarLilyEli Lilly USNDA 020509119961996/5/15P114402006.02.282010.05.151537

.

71DocetaxelTaxotereSanofi AventisSanofi FRNDA 020449119961996/5/14P565294complementary2007.07.142010.05.141035

.

72AnastrozoleArimidexAstrazenicaAstraZeneca UKNDA 020541119951995/12/27S16123262008.06.102009.12.27565

.

73Dexrazoxane HydrochlorideZinecardPharmacia and UpjohnPfizer USNDA 020212119951995/5/26P34411998.06.232003.06.231826

.

74Vinorelbine TartrateNavelbinePierre FabrePierre Fabre FRNDA 020388119941994/12/23P8136401999.08.202002.07.081053

.

75PegaspargaseOncasparEnzonEnzon USBLA10341119941994/2/11110/20/1989TRUE160

.

76PaclitaxelTaxolBristol Myers SquibbBristol Myers Squibb USNDA 020262119921992/12/29P9103/25/1997FALSE14071288complementary

.

77AldesleukinProleukinChironNovartis CHBLA10329319921992/5/5159/14/1988TRUE22992002.10.192006.05.051294

.

78Fludarabine PhosphateFludaraGenzymeSanofi FRNDA 020038119911991/4/18P834/18/1989TRUE285142001.02.242003.02.24730

.

79FilgrastimNeupogenAmgenAmgen USBLA10335319911991/2/20168/30/1990TRUE410929

.

80CarboplatinParaplatinBristol Myers SquibbBristol Myers Squibb USNDA 019880119891989/3/3P131113100complementary1996.02.201998.08.24916

.

81IfosfamideIfexBaxter HealthcareBaxter USNDA 019763119881988/12/30P448/7/1985TRUE193759complementary1990.05.081992.05.08731

.

82MesnaMesnexBaxter HealthcareBaxter USNDA 019884119881988/12/30P5211/14/1985TRUE1893complementary1998.12.062001.03.06821

.

83Leuprolide AcetateLupronAbbott LabsAbbott USNDA 019010119851985/4/9P517/25/1988FALSE1323381994.01.251996.01.25730

.

84Etoposide PhosphateVePesidBristol Myers SquibbBristol Myers Squibb USNDA 018768119831983/11/10P12391150complementarycomplementary

.

85Daunorubicin HydrochlorideCerubidineWyeth AyerstPfizer USNDA 050484119791979/12/19P382760complementarycomplementary

.

86CisplatinPlatinolBristol MyersBristol Myers Squibb USNDA 018057119781978/12/19S444/3/2000Before ODA03196269complementary

.

87Tamoxifen CitrateNolvadexAstazenecaAstraZeneca UKNDA 017970119771977/12/30S44839214complementarycomplementary

.

88DacarbazineDTIC-DOMEBayer HealthcareBayer DENDA 017575119751975/5/27S52949complementarycomplementary

.

89Doxorubicin HydrochlorideAdriamycin RDFPharmacia and UpjohnPfizer USNDA 050467119741974/8/7P5212/27/2006Before ODA04976382complementarycomplementary

.

90BleomycinBlenoxaneBristol Myers SquibbBristol Myers Squibb USNDA 050443119731973/7/31no entry539/17/1993Before ODA12860210complementarycomplementary

.

91Procarbazine HydrochlorideMatulaneSigma TauSigma Tau USNDA 016785119691969/7/22P144743complementarycomplementary

.

92CytarabineCytarabineTeva ParenteralTeva ILNDA 016793119691969/6/17P546/2/1993Before ODA129542complementarycomplementary

.

93Vinblastine SulfateVelbanLillyEli Lilly USNDA 012665119651965/11/5P2989122complementarycomplementary

.

94Vincristine SulfateOncovinLillyEli Lilly USNDA 014103119631963/7/20P216/24/2008Before ODA02193143complementarycomplementary

.

95FluorouracilFluorouracilValeantValeant CANDA 012209119621962/4/25P1042/6/1989Before ODA03012233complementarycomplementary

.

96CyclophosphamideCytoxanBaxter HealthcareBaxter USNDA 012141119591959/11/16P226/7/2011Before ODA05509415complementarycomplementary

.

97ChlorambucilLeukeranSmithklineGlaxoSmithKline UKNDA 010669119571957/3/18P125843complementarycomplementary

.

98PrednisoneMeticortenScheringBayer DENDA 009766119551955/2/21P72694179complementarycomplementary

.

99MethotrexateMethotrexate sodiumDAVADAVA USNDA 008085119531953/12/7P10410/21/1985Before ODA13991312complementarycomplementary

.

100Leucovorin CalciumLeucovorin calciumHospiraHospira USNDA 008107119521952/6/20P7312/8/1986Before ODA2119242