ABCDEF
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Biomarkers of Aging
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Change with AgeName MarkerMechanism of actionClinical research method Type specimen
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decreasehigh-density lipoproteingeneral, aging, risk of cardiovascular diseaseHDL activate the enzyme system in the liver, and antiatherogenic effect of HDL is due to their ability to transport cholesterol from the cells of the peripheral organs (including the vessels of the heart, arteries, brain, etc.) to the liver, where cholesterol is converted into bile acids and excreted. homogeneous enzymatic colorimetric test (mmol / L) blood serum
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increaselow-density lipoproteinaging, the risk of cardiovascular diseaseWe prove a direct link between high cholesterol levels and progressive formation of atherosclerotic plaques in the blood vessels, especially in the coronary arteries, which is the reason of having a coronary heart disease. calculated by Friedewald formula (mmol / L) blood serum
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increasevery low density lipoproteinsenzymatic (CHOD-PAP) blood serum
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increaseratio of low-density lipoprotein / LDL cholesterolGeneralWe prove a direct link between high cholesterol levels and progressive formation of atherosclerotic plaques in the blood vessels, especially in the coronary arteries, which is the reason of having a coronary heart disease. calculation (E) blood serum
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increaseTotal cholesterol (the husband)Potential agingWe prove a direct link between high cholesterol levels and progressive formation of atherosclerotic plaques in the blood vessels, especially in the coronary arteries, which is the reason of having a coronary heart disease. enzymatic (CHOD-PAP) (mmol / L) blood serum
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increasetotal cholesterolaging, the risk of cardiovascular diseaseWe prove a direct link between high cholesterol levels and progressive formation of atherosclerotic plaques in the blood vessels, especially in the coronary arteries, which is the reason of having a coronary heart disease. enzymatic (CHOD-PAP) (mmol / L) blood serum
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increaseTriglyceridesgeneral, the aging, the risk of coronary and peripheral atherosclerosishomogeneous enzymatic colorimetric test (mmol / L) blood serum
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decreaseratio of triglyceride / high-density cholesterolGeneralcalculation (E) blood serum
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decreaseapolipoprotein A1General, aging, atherosclerosisImmunoturbidimetric (mg / dL) blood serum
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increaseIn apolipoproteinaging, atherosclerosisImmunoturbidimetric (mg / dL) blood serum
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decreaseapolipoprotein EAging, Alzheimer's disease(Mg / dl) blood serum
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increaseratio of apo B / apo A1Generalpayment (s) blood serum
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increaseCirculating fatty acidsblood serum
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decreasephospholipids bloodGeneralEnzymatic determination of blood serum
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increaseAdiponectin (husband)Potential agingcorrelate with the risk of myocardial infarction in men enzyme multiplied immunoassay blood serum
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increaselipofuscinPotential agingaccumulates in cells during aging autofluorescence detection of lipofuscin blood plasma (with heparin and sodium fluoride as an inhibitor of glycolysis)
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Increase / DecreaseGlucosegeneral, aging, diabetes mellitus type I and IIreflects the status of carbohydrate metabolism glucose oxidase (GOD-PAP) (mmol / L) blood plasma (with heparin and sodium fluoride as an inhibitor of glycolysis)
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decreaseGlucose in the urineGeneral, aging, diabetesWhen the concentration of glucose in the blood over 8,8-9,9 mmol / L higher than the maximum capacity of the kidneys to the reverse suction NIJ glucose (renal threshold), or reducing this ability due to changes in renal tubular function, glucose appears in the urine - is observed glycosuria . With age, the renal threshold for glucose is reduced. hexokinase (mg / day) urine
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decreaseGlucose-tolerance testPotential aging, diabetesdetermination of glucose in the blood before and after sugar load. glucose oxidase (GOD-PAP) (%) blood plasma
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increaseThe end products of non-enzymatic glycosylationAgingformed during hyperglycemia blood serum
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increaseReceptors of the end products of non-enzymatic glycosylationAginghyperglycemia stimulates RKPG blood serum
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increasePentosidineaging, diabetes neinsulinzavisimogoHPLC blood serum
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increaseAlbuminaging, common, chronic liver disease, serdchnaya nedosttochnost, rheumatismcolorimetry (with bromocresol green) (g / l) blood serum
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decreaseratio of albumin / globulin bloodGeneral, inflammationinflammatory processes in the ratio decreases blood serum
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decreaseAlpha-1-acid glycoproteinGeneral, inflammationInflammation blood serum
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decreaseAlpha -1 microglobulinkidney damageblood serum
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increaseAlpha-2-macroglobulinGeneral, inflammationInflammation blood serum
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increasebeta2-microglobulintumorblood serum
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increaseAntistreptolysin-ORheumatic diseasesblood serum
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increaseAtrial natriuretic peptideHeart failureIncreases in tension fibrillation fluorescent immunoassay blood
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increaseBrain natriuretic peptide-ureticheskyHeart failureimmunochromatography (pg / ml) blood
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increaseHepatocupreinGeneral inflammation, rheumatoid arthritiscopper content in the body immunoturbidimetry (mg / ml) blood serum
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increaseC-natriuretic peptideHeart failuremarkers of the functional state of the contractile capacity of the heart muscle blood serum
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increaseEosinophilic cationic proteinGeneral, inflammationInflammation immunoassay plasma
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decreaseFerritingeneral, aging potential, a differential marker of anemia, cancer, inflammatory diseasesimmunoassay (ug / L) blood serum
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decreaseFructosamineGeneralindicator of blood glucose colorimetry (nitro blue tetrazolium) (mmol / L) blood serum
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decreaseGlobulinGeneralblood serum
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decreaseGlycosylated hemoglobinAging, diabetesshows what was the concentration of glucose for 4-8 weeks prior to the study cation exchange chromatography, high pressure (% of total hemoglobin) blood
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decreaseHaptoglobinInflammation, hemolysisAcute inflammation and intravascular hemolysis immunoturbidimetry (mg / l) blood plasma, blood serum
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decreaseHemoglobinGeneralcolorimetry (g / l) blood serum
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(decrease in multiple sclerosis)Homocysteinegeneral, aging, atherosclerosis, thrombosis, diabetes, Alzheimer's diseasein higher concentrations is cytotoxic immunosorbent assay (mmol / l) blood plasma, blood serum
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decreasethe average concentration of hemoglobinGeneralCalculated by dividing the concentration of hemoglobin (in g/100 ml) in hematocrit, and multiplying by 100. whole blood
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increaseMicroalbuminKidney damage, diabetesgets into the urine with kidney damage immunoturbidimetry (mg / l) urine
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decreaseMyelin basic proteindamaged nervous tissue, tumors, strokemarker of brain tissue damage radioimmunoassay spinal fluid
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Increase / DecreaseOsteocalcinOsteoporosisformed during the formation of bone tissue hemilyuministsentny "sandwich" 2-Site immunoassay specific for intact osteocalcin (1 - 49) and the fragment (1 - 43) (ng / ml) blood serum
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increaseTotal protein in the urineCommon, kidney damagecolorimetry, turbidimetry, diagnostic strips (g / d) urine
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decreaseTotal protein in serumgeneralazotometricheskie; gravimetric (weight), "pretsipitatsionnye"; spectrophotometric; Refractometric, colorimetric (g / l) blood serum
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increaseRheumatoid factorAutoimmune diseasesnephelometry, turbidimetry, immunofluorescence (IU / ml) blood serum
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decreaseProteinogram (protein fractions)General, inflammationelectrophoresis blood serum
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decreaseGlobulin, sex hormone bindingGeneralblood serum
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increaseThyroglobulinThyroid functioninto the blood in the destruction of the thyroid cells Immunoassay (ng / ml) blood serum
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decreaseTransferrininflammation, tumorimmunoturbidimetry (g / l) blood serum
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increaseTroponin Iheart disease, heart attackinto the blood in the destruction of cells immunochromatography, immunohemilyuminestsentny analysis (ng / ml) blood
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increaseTroponin Pheart disease, heart attackinto the blood in the destruction of cells immunochromatography, immunohemilyuminestsentny analysis blood
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increaseMyoglobindamaged muscle tissueinto the blood in the destruction of cells immunochromatography, immunohemilyuminestsentny analysis blood
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increaseTroponin Tmyocardialinto the blood in the destruction of cells reflectance photometry (ng / ml) whole blood with heparin
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increaseendothelinHeart failureImmunosorbent assay (pg / mol) blood
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increaseBig-endothelinHeart failureImmunosorbent assay (pg / mol) blood
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increaseC-reactive proteinaging, inflammation, rheumatoid diseases, tumorsInflammation Immunoturbidimetric (mg / l) blood plasma
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decreaseImmunoglobulin IgAAgingInflammation immunoassay (g / l) blood plasma
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decreaseImmunoglobulin IgGAgingInflammation immunoassay (g / l) blood plasma
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decreaseImmunoglobulin IgEAgingInflammation immunoassay (kU / L) blood plasma
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increaseImmunoglobulin IgMAgingAllergy immunoassay (g / l) blood plasma
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increaseconcentration of antagonist of interleukin-1Inflammation immunoassay blood plasma
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increaseconcentration of tumor necrosis factor alphainflammation, tumorInflammation immunoassay blood plasma
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increaseCMV IgG avidityAgingImmune aging immunoassay blood plasma
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increaseInterleukin 2inflammationInflammation immunoassay (U / ml) blood plasma
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increaseInterleukin 4inflammationInflammation immunoassay (U / ml) blood plasma
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increaseInterleukin 6AgingInflammation immunoassay (U / ml) blood plasma
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increaseInterleukin 10inflammationInflammation immunoassay (U / ml) blood plasma
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increaseInterferon gammainflammationInflammation immunoassay (U / ml) blood plasma
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increasecomponents of complement C3inflammationInflammation Immunoturbidimetry (g / l) blood serum
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increasecomponents of the complement C4inflammationInflammation Immunoturbidimetry (g / l) blood serum
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increaseBeta 2-microglobulininflammation, lymphoid tumorslevels of beta-2-microglobulin reflects the proliferation of lymphocytes and the intensity of cell turnover. immunoassay
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increaseGlial fibrillary acidic proteinaging, neurodegenerationenzyme multiplied immunoassay blood serum
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decreaseLon protease activityAgingenzyme multiplied immunoassay
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decreaseSplitting vector Na, Ca, glutathione and glucoseAgingimmunoassay
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increasePhosphorylated tau proteinAlzheimer's diseaseaccumulates in Alzheimer's disease immunoassay spinal fluid
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increaseTotal tau proteinAlzheimer's diseaseaccumulates in Alzheimer's disease immunoassay spinal fluid
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increase?-AmyloidAlzheimer's disease, dementia with Lewy bodiesaccumulates in amyloid plaques PET-detection of plaques stained Pittsburgh compound B, immuno-assay, atomic force microscopy NA
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increaseHantingtinHuntington's choreaaccumulates in Huntington's disease immunoassay diseased tissue
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increase?-SynucleinParkinson's disease, Alzheimer's disease, multiple system atrophy, dementia with Lewy bodiesaccumulates in Parkinson's disease immunoassay diseased tissue
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increaseprogerinaging, progeriaimmunofluorescence
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increasecytoplasmic tubulin in the nucleusAging
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decreaseThioredoxin 1aging, cancer, liver cancer, lungrestores the disulfide bonds, antioxidant activity
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decreasePeroxiredoxinAgingprotection of cells from oxidative stress and participate in the redox regulation of intracellular signaling.
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decreaseSuperoxide dismutaseaging, cardiovascular disease, diabetes, atherosclerosisantioxidant properties fotohemilyuminestsentsiya (U / g / Hb) blood serum
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increaseActive Cu, Zn-dependent supreoksiddismutazyaging nephropathy, ischemic myocarditis, rheumatoid arthritisfotohemilyuminestsentsiya blood serum
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decreaseGlutathioneGeneralantioxidant properties colorimetry blood serum
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decreaseglutathione peroxidase activityGeneralkinetic (mol / L min) blood serum
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decreasealpha-glutathione S-transferaseliver functionantioxidant properties kinetic (mol / L min) blood serum
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decreasepi-glutathione S-transferaseliver functionantioxidant properties kinetic (mol / L min) blood serum
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decreasecatalasePotential agingkinetic (mAbs / L) blood plasma
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increaseconcentration of 8-hydroxy-2-deoxyguanosinePotential agingdestruction of DNA
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increaseconcentration of malondialdehydePotential aging
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decreaseconcentration of carotenoidsPotential aging
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increaseconcentration of caveolin-1Potential aging
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increasePyridineosteoporosis, primary hyperparathyroidism, osteomalacia, diseases of the joints, metastasishigh performance liquid chromatography urine