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1 | Query | priority | Name | Search | Notes | JCBnotes | ASIDLnotes | link | ||||||||||||||
2 | How many solubility measurements have been done for nitromethane as solvent? | done | JCB/StephC | searched for all organics on Reaxy | did not complete - too many hits | this solvent noted as having suspect AD values - Andy thanks for the suggestion but I think there is something wrong with Reaxys so I'm waiting to hear back from the librarian first | Could limit to those compounds with known Abraham descriptors: http://lxsrv7.oru.edu/~alang/abrahamdescriptors/ | http://onschallenge.wikispaces.com/AbrahamSolventsModel001c | ||||||||||||||
3 | How many solubility measurements have been done for nitromethane as solvent? | done - add to solsum | JCB/StephC | searched for all carboxylic acids on Reaxys | 7 hits, mostly fatty acids - addition of values to solsum pending | this solvent noted as having suspect AD values | Could limit to those compounds with known Abraham descriptors: http://lxsrv7.oru.edu/~alang/abrahamdescriptors/ | http://onschallenge.wikispaces.com/AbrahamSolventsModel001c | ||||||||||||||
4 | How many solubility measurements have been done for carbon disulfide as solvent? | 1 | this solvent noted as having suspect AD values | Could limit to those compounds with known Abraham descriptors: http://lxsrv7.oru.edu/~alang/abrahamdescriptors/ | http://onschallenge.wikispaces.com/AbrahamSolventsModel001c | |||||||||||||||||
5 | How many solubility measurements have been done for N-formylmorpholine as solvent? | 1 | this solvent noted as having suspect AD values | Could limit to those compounds with known Abraham descriptors: http://lxsrv7.oru.edu/~alang/abrahamdescriptors/ | http://onschallenge.wikispaces.com/AbrahamSolventsModel001c | |||||||||||||||||
6 | Has anyone reported the oxidation of 4-chlorobenzaldehyde while trying to make an imine with aniline or another aromatic amine? | done | JCB | searched Reaxys for the target imine as a product | got 13 results, with several in ethanol - the main difference with Evan's reaction seems to be they used lower concentration in ethanol and equimolar (Evan had a large excess of the amine) | trying to discover mechanism for Evan's finding of oxidation instead of imine formation | http://showme.physics.drexel.edu/onsc/reactionattempts/advancedsearch.php?compound=&solvent=&reactiontype=oxidation&researcher=Evan+Curtin | |||||||||||||||
7 | Has anyone reported the oxidation of 4-chlorobenzaldehyde while trying to make an imine with aniline or another aromatic amine? | done | Mark | Searched Reaxys for reactions with 4-chloro-benzaldehyde with an aniline starting material substructure search | 337 reaction, three types of reactions only contained these two reactants and nothing else, these were reductive aminations, amides synthysis by oxidative amidation, and. catalytic preparations of amides. | trying to discover mechanism for Evan's finding of oxidation instead of imine formation | http://showme.physics.drexel.edu/onsc/reactionattempts/advancedsearch.php?compound=&solvent=&reactiontype=oxidation&researcher=Evan+Curtin | |||||||||||||||
8 | Has anyone reported the oxidation of 4-chlorobenzaldehyde while using ethanol as a reactant? | done | Mark | Searched Reaxys for reactions with 4-chloro-benzaldehyde with an ethanol starting material substructure search | 50 sources, none had 4-chlorobenzoic acid as a product, in almost every single case the ethanol reacted with the aldehyde to an acetal. In none did it oxidize into an acid. | trying to discover mechanism for Evan's finding of oxidation instead of imine formation | http://showme.physics.drexel.edu/onsc/reactionattempts/advancedsearch.php?compound=&solvent=&reactiontype=oxidation&researcher=Evan+Curtin | |||||||||||||||
9 | How many solubility reports for any organic compound in ethylene glycol? | done | Valentine | searched for acetic acid substructure | one hit - a methoxyimino acid - temperature study | |||||||||||||||||
10 | How many solubility reports for any organic compound in diethylene glycol? | done | Valentine | searched for acetic acid substructure | no hits | |||||||||||||||||
11 | How many solubility reports for any organic compound in glyme? | |||||||||||||||||||||
12 | How many solubility reports for any organic compound in ethylene glycol? | done | Valentine | searched for benzene substructure | 3 compounds | |||||||||||||||||
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