Regenerate. Rebalance.
Harmonize.
The nature of life
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The homeostatic ability to maintain the structure of tissues in the face of normal cell turnover or the loss of tissue damaged by trauma, aging or disease, is an essential development process that continues
throughout life.
The Regeneration
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The adaptive homeostasis
is a fundamental property of biological systems and implies a highly preserved process
for maintaining permissive conditions
to life.
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Characterized at the level of the entire organism, systemic homeostasis includes variables maintained within a dynamic range acceptable to the endocrine and autonomic nervous system, such as blood glucose levels, Na +, Ca 2+, O2, pH, blood osmolarity and body temperature.
Systemic homeostasis
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Stress...
Homeostasis Tissue
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Homeostasis Tissue
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Homeostasis Tissue
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Inflammation can be seen as the end of the spectrum of mechanisms that maintain and defend homeostasis
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Cellular homeostasis maintains a number of regulated variables including cell volume, osmolarity, electrolyte concentration (e.g. Na + , K
+ and Cl - concentrations), pH, membrane
potential and intracellular ion concentrations, proteins, nutrients, cholesterol, oxygen, and reactive oxygen species (ROS)
OXIDIA
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PeRMe
Regenerate means Rebalance
The goal of Personalized Regenerative Medicine is the study, analysis and remodeling of functions on processes that are useful to restore a molecular and cellular balance of organs and tissues in order to restore and/or optimize their biological functioning.
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It leads an interdisciplinary network of doctors, researchers, physicians, biologists and specialists active in the analysis, in the international study and dissemination of the most significant clinical therapeutic diagnostic publications and protocols of the receiving, applied and basic.
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is configured as a rational
highly integrated technologies and protocols, well validated experimentally to offer tools and proven therapeutic know-how
in order to enrich management strategies and consistent health practice models with increasingly significant expertise and eligible for translational research.
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Qualification. Determination. Customization.
The support of innovative molecular analysis, taken as an integrative component of predictive models and treatment paradigms, allow to combine data useful to the qualification of the individual molecular profile allowing a consistent customization on dietary strategies, integrative nutraceutical, pharmacological and therapeutic according to the crises of Medicine "Precision"
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AURING
TMR Tech Inside
Increase in tissue oxygenation Reduction of oxidation and inflammation
Acceleration of cell regeneration processes
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PeRMe
An advanced biophysical model, published in the literature, scientifically consolidated through clinical and biological evidence, the subject of an international patent on specific waves and frequencies.
Auring TMR technology with pulsed electromagnetic fields is distinguished by the ability to validate a therapy with synergistic action on tissue repair processes and cell regeneration processes.
Specifically, there are three main actions to support:
Cellular proliferation
Rna polymerase and cellular replication Hydrolysis and ATP synthesis: Restoration of membrane potential Reduction of oxidative stress: Reduction of «life» of free radicals
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Applications
Osteoporosis and bone edema Tendinitis and calcific tendinopathies
Epicondylitis
Arthritis, osteoarthritis and joint stiffness
Simple and difficult fractures
Delays in fracture consolidation Injuries resulting from surgery or trauma
Benefits
Reduction of local and systemic inflammation
Reduction of oxidative stress and
free radicals
Physiological relaxation and relaxation
Reduction of nociceptive pain
Applications
Degenerative Pathologies of Microcirculation
Diabetic Foot Injuries
Acute and/or Chronic Skin Lesions Vascular, Arterial and Mixed Lesions Vasculitic and Phlegmatic Lesions Post-surgical wounds
Trauma injuries
Difficult, neuropathic and decubitus ulcers
Sexual performance
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WEZONO
Improved oxygen release and use in the body
Local and systemic antibacterial and antiviral effect
Immunomodulating, antalgic and muscle relaxant action
Modulation of oxidative stress
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PeRMe
Medical ozone generator, characterized by great reliability and ease of use, designed for ozone therapy applications delivered in total safety and maximum precision.
Ozone is an oxidizing molecule, a kind of superseding oxygen, which, by reacting with blood components, generates a series of chemical messengers responsible for the activation of crucial biological functions such as oxygen supply, immune activation, the release of hormones and the induction of antioxidant enzymes, an exceptional property to correct chronic oxidative stress present in many pathological conditions.
In addition, by inducing the synthesis of nitric oxide, ozone therapy can mobilize endogenous stem cells, promoting the regeneration of ischemic tissues.
The biological bases of ozone therapy are totally in line with the classic biochemical, physiological and pharmacological knowledge.
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Evolution to simplicity�With Wezono we thought of a professional medical device that could give in a single technological element robustness, compactness and extreme portability in order to allow its use in various contexts with maximum efficiency.
Technology to evolution
Wezono has automatic syringe size recognition offering accurate and uniform O2/O3 mixture concentration through ACM (Algorithm Calculated Measurement) measurement system without calibration.
An integrated and reactive self-monitoring system with units outside the specifications allows the user safe and reliable applications.
A touch pad interface and a scrollbar with a high contrast LCD graphic display precisely guide the operator when using the device.
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iSEQ�Extra-cellular matrix remodeling and angiogenesis Biological stimulus to cell proliferation
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PeRMe
The CGF Medigen (Plasma rich in platelet-derived growth factors and CD34+ stem cells) is a new generation of platelet concentrates able to retain a greater concentration of autologous growth factors.
The product is isolated from blood samples by a simple and standardized separation protocol, without the addition of exogenous substances.
The patented kit, contains the necessary instrumentation for the collection, special dappen to facilitate the processing of blood components without any risk of contamination; for the creation of a fibrin membrane and for the insertion of the coagula in the implant site.
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Helmeet�Support for psychophysical well-being in response to stress �Synergic and regenerative stimulation of the senses �Aesthetic treatments of photobiomodulation
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Regenerative photobiomodulation
By means of light frequencies generated by a system of the latest electronic conception studied according to human anatomy.
Different wavelength emissions according to precise protocols allow treatments such as collagen and elastin neo genesis for toning and rejuvenation, skin disinfection, reduction of inflammation, and much more.
Prevention and treatment Chrono and Photo Aging Skin
Improving Facial Texture and Appearance Cutaneous Rejuvenation and Neocollagenogenesis Treatment of skin damage from stress
Acneic Skin Treatment
Complementary Sedative-Soothing Treatment - Post Invasive and Non-technological Treatments - Post Peeling - Rosacea, Couperose - Hair Folliculitis
Supplemental-Improving Complementary Treatment:
- Oily, Dry, Mixed, Sensitive Skin, Comedonic - Cutaneous Dyschromia - Seborrheic, Solar, Perioral Dermatitis
Long-Term Maintenance of Skin Rejuvenation Therapeutic Results
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From recent revisions on molecular evidence it becomes increasingly clear how the use of non- ionizing photon energy to trigger photochemical changes in cell structures receptive to photons (particularly in mitochondria, by stimulating the production of ATP energy through cytochrome C oxidase), tends to activate numerous signalling pathways via reactive oxygen species, cyclic AMP, NO and Ca2+
This mechanism calls for the activation of transcription factors capable of leading to greater expression of genes related to protein synthesis, cell migration and proliferation, anti-inflammatory signalling, anti-proteinsapoptotic and antioxidant enzymes.
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The patented synergic condition, generated by Healmeet, is designed to determine in the user a state of general relaxation in order to modulate an increase of endorphins contrasting the damaging action of cortisol, hormone that characterizes all conditions related to stress.
The contemporary integration between RGB LED light beams, generated at different frequencies and wavelengths, not harmful to the retina, specific binary music and inhalation aromatherapy with essential oils contributes to a highly relaxing and relaxing perceptive experience of the senses.
Destress and Recovery Therapy
Through sensory recreation, in reciprocal relationship of sight, hearing and smell, favoring the active process of neuronal interconnections for relaxing regeneration and psychophysical relaxation aimed at the production of endorphins.
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Research & Innovation
for molecular medicine
Born as SPIN-OFF of the National Research Council of Italy (CNR)
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Molecular medicine
Molecular diagnostics
Prevention and pathology
The medical approach of the 21st century fosters the association between the molecular and the clinical aspects for diagnosis, which allows the approach of PERSONALIZED MEDICINE.
Pathology
Biochemical analyses
Science
can help
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From molecules to cell
BODY FORMATION
BODY MANTAINANCE after growth
AGEING
The body is formed by molecules that are collected in cells. The living unit of tissues and organs is the CELL.
The REGENERATION of tissues and organs depends on the continuous turnover of cells and cell membranes
GROWTH
Keep the optimal cell regenerative power
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LIPIDOMICS
A new frontier in the health market, based on the
exploration of the cell membrane and its lipid composition
membrane
! The cell membrane composition plays an important role
in the overall status of the organism.
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Focus on cell membranes
Supramolecular organization
for CHANNEL and RECEPTOR
HOMEOSTASIS ROLE
PHOSPHOLIPIDS
SENSOR activity for signaling
EPIGENETIC ROLE
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Lipid diversity & essentiality
POLYUNSATURATED
Omega-6 and omega-3
SATURATED
MONOUNSATURATED
ESSENTIAL
Not prepared by the organism
To be obtained by the foods in the right quantity and quality
Double bonds
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Lipid pool/cluster
NUTRITION &
METABOLISM
Lipids from food to membranes
There are NOT
good and bad fats:
It is important
to understand
the fat balance for maintaining health
IN A PERSONALIZED WAY
The vision of lipidomics is dynamic, allowing to enter into the various steps of the individual metabolism that link nutrition to the formation of cell membrane
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The big opportunity for health:
Lipidomics in health and pathologies
WHERE: the functional and structural MEMBRANE compartment
WHY: MEMBRANE is a PRIORITY for the cell
WHEN: at least one time per year, choosing the representative cell for diet and metabolism
ANALYSING the MEMBRANE LIPIDOME
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MATURE RED BLOOD CELLS
Cell selection
NO DRY BLOOD SPOT
NO PLASMA
3 months
MATURE ERYTHROCYTE:
TRUE REPORTER of the balance between DIET and METABOLISM due to its EXCHANGE with OTHER TISSUES in the BODY during its life time (> 3 months)
SELECTION
In order to examine the representative cell for metabolism and diet
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Determination of the individual lipidomic profile recording medical history and eating habits, followed by evaluation, information and personalized guidance using dietary and nutraceutical recommendations, and monitoring of the individual both during and after the re-equilibration period
Lipidomic strategy by Lipinutragen
profile
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Now available to the public, the advanced and innovative tool of molecular medicine in the hands of the professional Doctor / Specialist: the cell membrane lipidomic analysis FAT PROFILE®.
Prevention
Diagnosis
Personalized treatment
based on nutra-strategies.
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FAT PROFILE®
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5. Personalized molecular
profile and NUTRILIPIDOMIC
Supplementation
(direct treatment to the membrane for its
re-balance to follow for 4 months - 3 weeks
per month)
4. Reliable and repeatable
analytical protocol for
the analysis of the
membrane cluster
3. Cell selection
EXCLUSIVE ROBOTICS
2. Questionnaire
diet – anamnesis
+ consent + privacy
1. Venous blood sample
(finger or forearm withdrawal)
Analysis – medical report procedure
GC analysis
Trails in prevention and in the course of disease and therapy
How does it work?
Patients fill out a medical history questionnaire and dietary habits. The samples obtained by a simple venipuncture* or finger blood withdrawal (20 drops)* are sent to the Lipidomic Laboratory of Lipinutragen (Health Aut. 201182/12 CF, Municipality of Bologna). The automated procedure, by a robotics that is specific and exclusive by Lipinutragen, (certified by Accredia ISO 17025) executes the selection of mature red blood cell and processing to the fatty acid analysis. The result is a table with analytical data (the membrane fatty acids representative cluster) that outline a personalized molecular profile, connected to the patient data reported on the questionnaire. It is important to fill out the medical history questionnaire / dietary habits, and deliver the privacy and consent documents together with the sampling kit.
*not necessary fasting for sampling; the levy may be finger (20 drops) or forearm (max 1 ml).
3 months
ISO 17025
accreditation
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The analytical result is read by the specialist in lipidomics and the personalized nutraceutical and nutritional interventions are identified.
The follow-up for 4 months produces a re-equilibrium of the cell membrane composition with health benefits.
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The cell membrane composition plays an important role in the overall status of the organism.
The main areas of application of the lipidomic profile are:
Areas of applications
• Physical activity and wellbeing
• Mental activity
• Pregnancy
• Cardiovascular diseases
• Neurological disorders (mental disorders, depression, autism)
• Ophthalmological disorders
• Alzheimer Prevention
• Cancer patient support
• Cystic fibrosis
• Dermatological diseases
• Metabolic disorders
• Obesity
and others…
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