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Prof SH Connell

  1. AfLS History : 2 decades 🡪 AfLS 🡪 IAC, LoS / MoU, CDR
  2. AfLS Motivations and Science
  3. Formal Roadmap in progress since 2015
    • Bottom Up: Training, User Base, W/S, Conferences, Networks
    • Top Down: Governments, AU, National & Pan African VAs, PBs, Stakeholders
  4. Conference
  5. Perspectives
  6. Upcoming

Useful Websites

WG14 – Accelerator Science

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Africa already has experience in International Large-Scale Research Infrastructures

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Africa already has experience in International Large-Scale Research Infrastructures

Research with MeerKAT … kernel of SKA

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Johannesburg – Soccer World Cup 2010

SESAME in the Middle East

Egypt is the first African country to have country-based membership of an international light source. It participates as a member of SESAME along with the Middle East countries of Cyprus, Iran, Israel, Jordan, Pakistan, the Palestine and Turkey

What is a synchrotron

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Sirius in Brazil

90% local manufacture

What is a synchrotron

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Advanced Light Sources

  • 50 World Wide
  • Remain open during Lockdown
  • Essential Service - Determine the SARS CoV 2 Structure
  • Function from form
  • Determine drug targets 🡪 test medical interventions 🡪 vaccines

African Disease Burden

Already African scientists produce excellence

  1. TB
  2. Malaria
  3. HIV Aids
  4. Ebola
  5. SARS-CoV-2
  6. Many others

https://www.africanlightsource.org �$2B large scale multi-disciplinary research infrastructure

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The alba synchrotron is located in very special surroundings: in the Barcelona synchrotron park. home to not only the synchrotron itself, it is in its own right a science and technology park with 400,000 m2 of productive floor space, with 55 plots from 2,100 to 36,000 m2. Its mission is to offer innovative companies a unique  ecosystem in which to concentrate on both growth and production.

The Light Source

Typically seeding a mega science and innovation park

one of many examples

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Sirius in Brazil

90% local manufacture

What is a synchrotron

Some examples of Science with Synchrotrons

Multidisciplinary

  • Research
  • Technology
  • Industry

* Credit inferred from each slide

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Why the AfLS ?

  1. African Challenges 🡪 Identify Science 🡪 Identify RI 🡪 AfLS
    1. Examples in these slides
    2. Health (African vaccine IP), Big Data Analytics, Others 🡪 All RIs
  2. Insist on evolution towards major African funding
  3. RI for Science Diplomacy 🡪 Developing Pan Africanism
    • SESAME
    • CERN
  4. AfLS profile for African Government Science Policy, Regional Science Policy 🡪 Leave no country behind
  5. Governance 🡪 African participation on RI Councils
  6. African User Base development (Training, Youth)
    • Schools, Workshops,
    • Medium term visits,
    • Sandwich programmes

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Socio-economic benefits

  • Boost African Scientific Research, Research Capacity (Continent, regions, Institutes), Capacity Building - African Science Renaissance
  • Global Research Community
  • Tackling Diseases (Malaria, TB, Aids, Ebola ....)
  • Unique African Research Opportunities attracting international collaboration : Energy opportunities, African Environment, Cradle of Humankind, Cradle of Culture, Mineral beneficiation, Agriculture.
  • Mobility, Conferences, Schools, International Mentoring partnerships in student training, Regional Centres of Excellence, Local feeder instrumentation
  • Build Research capacity in Industry, competitive industry
  • Science for Peace (eg CERN, SESAME)
  • Return of the African Science Diaspora - new opportunities for young excellent scientists
  • For African countries to take control of their destinies and become major players in the international community

  • Technological Advances 🡪 Now at 4th Gen 🡪 FoM x 10000 🡪 Urgent for Africa to get in the game

What is a synchrotron

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1 measured point 🡪 4D data

(3 space and time) improvements

of 102 - 104

What is a synchrotron – Technological Advances

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Synchrotron X-rays

ESRF Extremely Brilliant Source

The 1st high-energy 4th-generation synchrotron light source

Pantaleo Raimondi wins the Gersch Budker IPAC17 Prize

For his invention of the “Hybrid Multi Bend Achromat” (HMBA) lattice, which has become the design basis of most future “fourth generation” synchrotron sources in the world

1024

1023

1022

1021

1020

1019

1018

1017

1016

1015

1014

1013

1012

1011

1010

109

108

107

106

1900 1920 1940 1960 1980 2000 2020

Brilliance (photons/s/mm2/mrad2/0.1%BW)

X-ray tubes

First generation

Second generation

Synchrotron Radiation

Third

generation

ESRF (2018)

ESRF (1994)

ESRF-EBS (2020)

x10

Emittance before and after EBS

X 100 improvement in beam emittance, x100 improvement in detectors

X 10000 Figure of Merit improvement

What is a synchrotron – Technological Advances

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Sirius in Brazil

90% local manufacture

What is a synchrotron

Berkeley

ALS-II

Argonne

APS UP

Oxford

DLS-II

Paris

SOLEIL-II

Grenoble

ESRF

PSI

SLS-II

Trieste

Elettra-II

Hamburg

Petra-IV

Russia 4th Gen Synchrotron

Beijing 4th Gen Synchrotron

Harima

Spring 8 II

Novosibirsk

VEPP V

India

4th Gen Synchrotron

Sao Paolo

LNLS II

Why are there

currently 14 major upgrades / new builds ?

Graphic adapted from ESRF source

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UN Report “World Population Prospects” (2017)

More than half of global population growth by 2050 will happen in Africa

This means a lot of young people, and points to an urgent need for human capacity building

Africa

What is a synchrotron – Africa needs it yesterday !

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Africa has 1.2 billion people

169 scientists per million people (UNESCO Science Report 2015)

Italy : 2600/million

Germany : 7600/million

Africa needs at least ……

1 000 000 scientists to get 1/6 of <1st world>

What is a synchrotron – Africa needs it yesterday !

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Who is African ?

Someone born in Africa

African Ancestry

African Diaspora

……. and ……

To be an African,

you do not need to be born in Africa,

….. Africa must be born in you

Arikana Chihombori-Quao

AU representative to USA 2017-2019

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Global and Africa relevant Research and Innovation – by Africans and partners

African Cultural and Paleo Heritage

Developing medical interventions for Africa’s disease burden, Malaria, HIV, TB, Ebola ….

AfLS-CDR Conceptual Design Report

Beneficiating Africa’s mineral wealth: Mining Review Africa

Energy Materials

Innovations

….. and much more

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Thuma mina – Send Me

https://www.youtube.com/watch?v=d4Bwux-btq0

Musician Hugh Masekela

Inspiring Africa and the World

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AfLS2020 �IAC, LoS/MoU�CDR Process

Many AfLS Roadmap related activities

Letter to SA-NRF

SA Synchrotron Initiative

First publications from Egypt then SA

1st formal Pan-African call. AfLS is in the ALC launch docs

2010

2005

2000

1995

1990

Global conversations about the AfLS

Formation of AfLS Interim Steering Committee

AfLS1 Conference and AfLS SC

AfLS2 Conference

AU: STC-EST, AAS call to support AfLS as a Pan African initiative

AU: Exec Council call to support AfLS as a Pan African initiative

Ghana Govt support

AfLS Foundation Legal Entity

2015

1st African HE Summit : AfLS in the Declaration

2020

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Bottom Up

  1. Human Capacity: scientists, engineers, technicians
  2. African scientists access existing LSs
  3. African relationships with existing LSs.
  4. Involvement of industry
  5. Community for the African light source Users
  6. Outreach

Top Down

  1. Strategic approach to African Governments and (Pan) African orgs.
  2. Conceptual Design Report (CDR)
  3. Inter-African co-operation on Local / Regional feeder infrastructure
  4. African multinational beamlines at existing LSs
  5. Regional / Pan African membership of existing LSs
  6. Technical Design Report (TDR)

MoU

LoS

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Conferences

2015, 2019, 2020,

2021, 2022

2021

>500 registrations

2021

Now 5 African Governments involved

Many co-conveners

Prof bodies

Academies

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Conceptual Design Review

CDR 5 Volumes

Volume I. �Scientific, Socio-Economic, Educational and Political Benefits

Volume II. �Machine Design Concepts

Volume III. �Scientific Capabilities and Beamline Technical Concepts

Volume IV. �Building Design and Infrastructure

Volume V. �Finance, Governance

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The AfLS should be seen in the context of

  1. Pan Africanism
  2. Science as a Global Endeavour
  3. Science for Development
  4. Science for Innovation
  5. Innovation for Wealth Generation
  6. Decolonisation of Africa
  7. Massive training
  8. Africa must sustain costs ($1Bn + $2BN over 20 years)
  9. Competitive machine (no pass-offs)

CDR for AfLS

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Debating the Societal Impact of Big Science in the 21st Century

To appear soon …..

AfLS Profile – Authoring – Website – Social Media

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  • Structural information helps to elucidate function, the mechanisms of enzymes 🡪 inspires the design of new drugs.
  • Africa should lead research of this nature 🡪 cures for diseases of particular relevance to Africa
  • Synchrotrons are extremely important facilities for the imaging of bio-molecules.
  • Development of 210 new drugs that depended on protein structural information [Westbrook et al. 2019].
  • Development of drugs for treating HIV-AIDS, [Wlodawer et al. 1998].
  • Listing of about drugs, their targets “Practical Fragments” Website [Prac. Frag 2018].
  • Development of new treatments for tuberculosis [Blundell 2017a ].
  • Interplay between academia and industry [Blundell 2017b].
  • See Light Sources for vaccine development for the current Pandemic [AfLS web page]

Example motivation based on Bio Science

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African Light Source Based Science

Science of special interest to Africa - some examples, of many

  1. Materials
    • Very many examples

See talk of Prof Diale “Energy Materials – nano science” http://events.saip.org.za/conferenceTimeTable.py?confId=211#20201118.detailed

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The African Light Source

Project

Trevor Sewell – UCT – South Africa

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The African Light Source

Project

Trevor Sewell – UCT – South Africa

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Dr Thandeka Moyo

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Historical documents : Timbuktu

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Paul Tafforeaux

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Medical CT scanner

Paul Tafforeaux

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ESRF ID17 beamline,

Monochromatic beam

Paul Tafforeaux

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Paul Tafforeaux

Broomistega : Temnospondyl amphibian, aquatic predator, the best skeleton ever discovered

Thrinaxodon : Mammalian reptile, close to the origin of mammals

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© Vincent Fernandez

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Paul Tafforeaux

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Dental replacement�Abdala et al. 2013� J. Vert. Paleontol.

Cranial ontogeny�Jasinoski et al. 2015

Functional morphology

Iqbal et al. en prep

Vertebral biomechanics

S. Pierce; K. Angielczyk

Paul Tafforeaux

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Berger shows fossils to South African President Jacob Zuma

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ESRF Grenoble France

22 PARTNER COUNTRIES

13 Member states:

France 27.5 %

Germany 24.0 %

Italy 13.2 %

United Kingdom 10.5 %

Russia 6.0 %

Benesync 5.8 %

(Belgium, The Netherlands)

Nordsync 5.0 %

(Denmark, Finland, Norway, Sweden)

Spain 4.0 %

Switzerland 4.0 %

10 Associate countries:

Austria 1.75 %

Israel 1.75 %

Centralsync 1.05 %

(Czech Republic, Hungary, Slovakia)

Poland 1.00 %

Portugal 1.00 %

India 0.66 %

South Africa 0.30 %

  • Staff: ~ 650
  • Partner countries’ contributions: ~ 85 M€/year
  • Annual Operation Budget: ~100 M€
  • Access based on scientific excellence
  • Travel and local costs refunded to users

Contact SRRIC Chair Tshepo Ntsoane

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Article 5.3.2 p 22 : Recommends establishing a Synchrotron as a centralized African scientific facility.

Co written by

Dr Nkem Khumbah,

STEM-Africa Initiative

Declaration and Action Plan

1st African Higher Education Summit on Revitalizing Higher Education for Africa’s Future,

10-12 March 2015, Dakar, Senegal.

Top Down

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Specialized Technical Committee on Education, Science and Technology

Africa Union : STC-EST

20 October 2017 Egypt

H.E. Prof. Sarah Anyang Agbor

AU Commissioner for Human Resources, Science and Technology.

African Academy of Science

President Prof. Felix Dapare Dakora

Presentation on African Light Source

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AfLS at the AU : Jan 2018

DECISION ON THE REPORTS OF THE

SPECIALISED TECHNICAL COMMITTEES (STCs)

The Executive Council,

C. STC ON EDUCATION, SCIENCE AND TECHNOLOGY

  1. CALLS UPON Member States to support the Pan-African Synchrotron Initiative;

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Countries Expressing Commitment

Ghana

2019, the President Akufo-Addo of Ghana

pledged to champion the project in the African Union.

2020, the science minister, Dr. Kwabena Frimpong-Boateng,

reaffirmed Ghana’s support for the African light source

Benin

2019, X-TechLab, as a government priority project,

expresses itself as part of the Roadmap to the AfLS.

SA

2021, SA Dept Science and Innovation and the NRF invite�a proposal towards the AfLS as a “Flagship Project”

2021, Nigeria

Office of the Science Ministry

2021, Cote d’Ivoire

Office of the Science Ministry

2021, AUC-HRST

Developing Process and Actions

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Some Government, Pan African organization and AU level events

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 Pan African scholarly associations, supporting the AfLS co-convening / co-organizer AfLs Conferences,  

Also …. Support from  AAU and ARUA, and other members of NASAC

Art, Cultural Heritage, and Forensics

LNLS, Center for Scientific Studies in the Arts

Biochemistry

Federation of African Societies of Biochemistry and Molecular Biology (FASBMB)

Bioimaging

African Bioimaging Consortium (ABIC)

Chemistry

Federation of African Societies of Chemistry (FASC)

Crystallography

African Crystallographic Association (AfCA)

Earth Sciences

African Institute for Planetary and Space Sciences (AIPSS)

Geophysics

African Geophysical Society (AGS)

Electrical Engineering

IEEE-Africa, IEEE Region 8

Engineering

Federation of African Engineering Organizations (FAEO)

Food Science

South African Association for Food Science and Technology (SAAFoST)

Immunology

Federation of African Immunological Societies (FAIS)

Materials Science

African Materials Research Society (AMRS)

Medical Physics

Federation of African Medical Physics Organizations (FAMPO)

Nanoscience and Nanotechnology

African Society for Nanoscience and Nanotechnology (AfNN)

Optics/Photonics

African Optics and Photonics Society (AfOPS)

Paleontology

Eastern African Association for Palaeoanthropology and Palaeontology (EAAPP)

Physics

African Physical Society

Structural Biology

Biostruct Africa

Water Science

African Water Association

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AfLS 2020�Participation by community, PBs, VAs, AdLS

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Some Existing Regional Facilities

X-TechLab - Benin

Materials analysis, spectroscopy for many disciplines.

Energy, health, environment, agriculture, materials

Sir Aaron Klug Centre - SA

Structural biology resource widely used in SADEC region

African Laser Centre

Pan-African NEPAD flagship initiative

ICTP-EAIFR - Rwanda

Condensed matter, Geology, Particle Physics, �Cosmology, Astroparticle physics

Others ….

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AfLS : Plenary Session at COREVIP 2019

The AfLS was endorsed in a Conference Resolution

Proceeding to develop MoU for Formal Collaboration

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PhD / Paper / Programme

28/52 > 50%

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Example of African Industry :

SASOL investment in R&D and HC

SASOL capacity, achievements in catalysis studies – local and at light sources

from Dr E du Plessis at AfLS2015

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Ghana

University of Ghana

Zambia

The University of Zambia

Algeria

Ecole Nationale Polytechnique de Constantine

Nigeria

Federal University of Technology, Akure

University Ile-Ife

Burkina Faso

Institute of Research in Health Sciences, Burkina Faso

Morocco

University Sidi Mohamed Ben Abdellah

Ivory Coast

Universite Felix Houphouet Boigny

Egypt

Helwan University, Ain Shams University

Lesotho

National University of Lesotho

Ethiopia

Addis Ababa University

Bio-Science Capacity in Africa

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  1. South Africa
    • Aaron Klug Centre, UCT, link, �U Witwatersrand, U Free State, �U Stellenbosch, iThemba

  • Benin, X-TechLab, Benin, link
  • Ghana, U Ghana, link
  • Côte d'Ivoire, LaCPM, Universite Felix �Houphouet Boigny, Abidjan, link
  • Senegal, Ziguinchor, link
  • Cameroon, Dschang, link
  • Kenya, Kenyatta University, link
  • Tunisia
    • Monastir, link, Nabuel, Tunisia, link
  • Algeria, Constantine 1, link
  • Morocco
    • U Rabat,, link, El Jadida, Morocco, link , �Agidir, Morocco, link

Significant facilities

IUCr OpenLab venues with facilities

Feeder Facilities

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Example of a local facility growing into a regional facility

Bottom Up

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Several significant training interventions

Bottom Up

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Bottom Up

  • Training
  • Mobility
  • Networking
  • Local Facilities
  • Conferences

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2023 FAST Team call (deadline 30 Sept 2022)

https://events.saip.org.za/e/LAAAMP2023

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START is a collaborative project that seeks �to foster the development of Synchrotron �Techniques for African Research and �Technology.

Two lines of scientific investigation:

  1. New energy materials (eg solar cells, novel catalysts)
  2. Structural biology studying diseases and develop �drug targets.

Jump-start Africa’s entry into synchrotron based bioscience.

SA, Lesotho, Ethiopia participation so far ……

Capacity in Africa

Bottom Up

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The African Light Source : EU - AU

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The Africa Light Source Foundation

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Capacity in Africa

Bottom Up

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63rd IAEA General Conference

AfLS, Thais, SESAME and Elettra,  African govt reps.

September 16-21 2019

90-min slot dedicated to synchrotron applications, showing usefulness to both developed and developing countries, “side event”, of Sep 17.

Recent AfLS Events

Bottom Up

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The African Light Source : ACP

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>500 registrations

Now 5 African Governments involved

Many co-conveners

Prof bodies

Academies

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The African Light Source : DOE

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International Advisory Committee

The Africa Light Source Foundation

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The African Light Source : BioPhysics in Africa

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AfLS and Biophysics

African health is a special case for Structural Biology on the continent and the AfLS

  1. Training Programmes, building the User Base
    1. START – continuation, SA-ESRF continuation
    2. Others
  2. Local and regional equipment infrastructure
  3. African Governments positions creating African excellence in Bio Sciences
    • Build activities at University Departments
    • AKC as a regional Centre, support as a CoE
    • BioStruct Africa
    • Other National, Regional and African initiatives
  4. Regional African Partnerships
    • African Beamline at a International facility
    • Multi-state membership of an international facility

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The African Light Source : DOE

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2022 and 2021 events

  • Hands- on training in Structural Biology, a tool for sustainable development in Africa Malaria Research and Training Centre (MRTC) in Bamako, Mali 25-28 April 2022
  • SESAME-Africa online workshop 6 July 2022
  • UNGA Science Summit Events 18-27 September 2022
  • Africa-US Symposium on Synchrotron Science 12-14 October 2022
  • International Conference on Research Infrastructures (ICRI) 17-18 October 2022
  • Training Workshop on Synchrotron Technologies and Techniques and their Applications 25-29 July 2022
  • AfLS4-2022 Virtual Conference from 14-18 November 2022 hosted virtually by BIUST, Botswana.

AfLS engaging from grassroots science and scientists level, up to the policy/politician level

The Africa Light Source Foundation

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The African Light Source : DOE

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Pan African Virtual University in Light Source Based Science

Pan African University PAU

Hosted within existing Universities

  1. PAU Statutes, Governance Structure, Council and Senate
  2. Each Institute has other institutions operating under it.

Proposal

  1. Desktop study of Statutes, see how the PAVULBS can be set up within PAU structures
  2. Integrate into existing Institute or set up a new one
  3. How the institutes are funded, and evaluation of proposals compatible with the funding.
  4. Make list of clear options

The Africa Light Source Foundation

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The African Light Source : DOE

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The Africa Light Source Foundation

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The African Light Source : EU - AU

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African Scientists and International Light Sources

  1. African scientists / projects at Light Sources
    1. See large footprint slide 14 (50%)
    2. African Science Diaspora
  2. Africa long since over-threshold (>300 Users) for own LS
  3. International light sources involved in training
    • ESRF, SOLEIL, DIAMOND, Elettra, DESY, Bessy, Alba APS, LNLS, Spring8, ALS, CLS, DELTA, MAC IV, Phton Factory, Pohang AL, SESAME, Siam PS, SLAC, Taiwan PS, others
    • Now via LAAAMP. https://laaamp.iucr.org
  4. African Regional Membership of EU Light Source
    • Expand SA – ESRF Scientific Associateship ?
  5. African (Regional) Beamline
    • (MX, Paleo Tomography, materials …)

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The African Light Source : EU - AU

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Towards and African Membership of a International AdLS

  1. Academic Output
  2. Capacity Building, Deep training
  3. User base, Community building, Interdisciplinarity
    1. Example: towards African Vaccine development capacity
    2. Coherence in Local Community
  4. Win-win : AdLS access to SA premier research projects and colleagues
  5. Policy maker involvement
  6. International networks
  7. Technology transfer
    • Techniques, sample prep, instrumentation, big data ….
  8. African (beyond SA) participation
  9. AfLS Project

The Africa Light Source Foundation

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Young scientists ….. Can you see yourself here….

The Africa Light Source Foundation

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Backup

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Registered as a Trust

With a Constitution

Bank Account established

Receiving funds

Appointed Auditor

Access to staff

Registration as a Public Benefit Organization (PBO)

AfLS

Legal Entity

Supported by SAIP Council and assisted by SAIP Exec Office

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AfLS meeting : 2016 Conference - Concrete outcomes.

  1. Grenoble Resolutions.
  2. Terms of Reference.
  3. Roadmap summary.
  4. Steering Committee to drive this roadmap forward.

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Long history of association of many synchrotrons with AfLS

ESRF, SESAME, Elettra, Alba, SOLEIL, Diamond, Sirius and UVX, DESY, LNLS, CHESS, SLAC, SPRING8, Taiwan, ALS, CANDLE, APS, …. (others too, and no particular order)

AfLS encourages connections that enhance its vision to all.

Driven by :

Bottom up (scientists, collaborations, training, history ….)

Top Down (strategy and policy

AfLS and LS world wide

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International Advisory Committee

The Africa Light Source Foundation

Towards a Lightsource for the African Continent