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Over three billion years ago, blue-green algae were the first living Prokaryota to produce oxygen, halocarbons (such as CH3I) in the atmosphere, and PUFAs in lipid membranes.

About 500-600 million years ago (Mya) when the primitive brain evolved

in marine animals, thyroid cells originated from the primitive gut in vertebrates, migrated, and specialized in the uptake and storage of iodocompounds in a novel follicular “thyroidal” kind of structure that served as a reservoir for iodine. The management and release of iodine – the pituitary-hypothalamus-thyroid axis - required the development of brain functions that developed to serve expanded cognitive functions.

Three to four hundred million years ago some vertebrates evolved into amphibians and reptiles and moved to I-deficient land.

Thyroid hormones became active agents in the metamorphosis and thermogenesis of vertebrates, facilitating their adaptation to the terrestrial environment.

The dry terrestrial diet firstly stimulated in amphibians the formation of I-concentrating salivary glands. (We’ll talk about what this means for personal and public health.)

About 200 Mya came the formation of I-concentrating mammary gland in mammals

Iodine then played a central role in brain development. This needed to occur on the littoral (coastal) areas of the young planet, where ocean-arising iodine-rich clouds watered plants and created an iodine-rich diet. NO LONGER TRUE. We are all iodine deficient.

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Iodine Attributes

Iodine is extracted from blood and plasma by specialized cells – and stored. These processes evolved millions of years ago as mammals left the iodine-rich ocean for land. The oldest, most effective antioxidant known, iodine is a key to disease resistance, cell reproduction and basal metabolism. Brain, nerves and organ functions are impossible without it. All cells need iodine for DNA transcription. Iodine is central to life and protects it from destruction by infectious diseases.

Many of the drug advances of the past century are being overturned as bacteria, mold, yeasts, viruses, fungi, & archaea develop drug-resistance. The WHO calls it “Not just some apocalyptic fantasy.” But iodine: there is not ONE instance of microbes resistant to its killing ability. Deployed along with “standard of care” therapies, iodine increases drug efficacy many times over. 75,000 people die yearly (U.S. only) from drug-resistant hospital microbes…nearly 2x annual highway deaths.

In Mammals

In Microbes

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Key Features of Iodine

Special iodine-extraction cell mechanisms developed in key organs as we left the ocean
Natrium-Iodide Symporter (NIS): 643 amino acid “filter” pulls iodide into cells, esp. to mitochondria
Present in thyroid, & gut, kidneys, salivary glands, mammary glands, thymus, testes, etc
Each organ uses extracted iodine for key life-critical metabolic functions (thyroid: T3-T4 syntheses; salivary: microbe protection, mammary: fetal/infant growth, etc.)
Only thyroid use is well-understood
Iodide reacts with glutathione peroxidases to form Hypoiodous acid, a powerful antimicrobial – in all non-blood-bearing channels (e.g., all ducts)

Chlorine, Fluorine, Bromine: All are volatile, toxic and dangerous in metabolic systems. Their relatively low atomic masses (35.4, 79.9, 18.9 respectively) compared to iodine (126.9) indicates the dangerous potential for their replacing iodine – if present in biological systems. “Goitrogens” do this, disabling life.

Iodine: It is a life-critical “micro” nutrient, under constant depletion in soil, stored for long periods in mammals, and only recently understood in human biology & nutrition.

Birth/Senescence: Not one cell is born or dies without a molecule of iodine. NOT ONE

Evolutionary History

Unique Among Halides

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Brief Life History of Iodine

200MM years ago, present only in soil
Last Ice Age “scraped” iodine into the oceans
Evolutionary biology says that life arose in & around seaweed beds
Seaweed concentrates iodine thousands of times

Iodine is the heaviest element in the body
Its chemical behavior allows for multiple functional pathways
Iodine was vital during early life’s development to disable oxygen’s reactivity, moderating reactive oxygen species

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Salt Iodization: Faltering & Failing

Since the 1920’s, Europe and the Americas relied on iodized salt (NaCl + potassium iodide) as a bulwark against iodine deficiencies. Incidental sources are gone (dairy, eggs, vegetables, bread). WHO: “54% of the world’s population is iodine deficient.”

Result: Lowered intelligence in infants, newborns and youngsters; heart disease, tuberculosis, infective endocarditis, tooth & gum decay, breast & prostate cancer, diabetes, celiac disease, IBD. These are avoidable, perhaps curable.

Endocrine Society, 2014: A CALL TO ACTION: “Absence of a public health policy in the face of clear documentation of moderate iodine deficiency and strong evidence of its deleterious effect on the neurodevelopment of children is ill-advised.” Lancet, 2013: “Results from studies show that the cognitive ability of offspring might be irreversibly damaged as a result of their mother's mild iodine deficiency during pregnancy.” Nutrition Journal, 2013: “Despite adequate supplementation, most pregnant women appear to be iodine deficient.”

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Founder - Eugene Rosov

Harvard College – Class of 1968
Created, Ran, Sold 3 public companies

Each about 10 years
Water analysis (#1), prepaid phone cards (#2), video-conferencing (#3), malpractice insurance (#4)
#1: Public via acquisition of a NYSE conglomerate
#2: Public in New Hampshire only
#3: Public directly on the NASDAQ (Ladenburg)
#4: Owned by its investor/physicians – malpractice insurance w/focus on pt/dr. arbitration

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Board of Advisors

Chair of Pediatric Cardiology & Pharmacology, Univ. of Miami (Henry Gelband, MD)
Prof. of Internal Medicine & Biostatistics, Univ. of CA/San Francisco (Michael Martin, MD)
Dir. of Pathology & Microbiology, Univ. of TX, MD Anderson Cancer (Jeffrey Tarrand, MD)
Prof. Inorganic Chemistry, Univ. of TX, (Purnendu Dasgupta, Ph.D)
2 Other physicians (Florida & New Jersey)

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A Three-Part Mission

PART ONE

DEVELOP & SELL IODINE-INFUSED PRODUCTS

Hand Sanitizer
Dental Floss
Toothpaste
Eye-Care Roll-on

Dry Eye, Red Eye
Blepharitis (Meibomian gland issues)

Encourage adjunctive prescribing with “accepted” standard-of-care pharmaceuticals
Supplements for illness, pregnancy, general health
Personal products (toothpaste, mouthwash, scrub)
Dental products: floss, toothpicks, gargle, toothpaste

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PART TWO

DELIVER IODINE via INHALATION SYSTEMS & Supplementation

Passive Iodine Inhaler – Molecular I2 to Blood
Liquid Mask: an Oral/Nasal 1% PVP-I product with several adjuvants

Proven in dozens of clinical studies in hospitals & clinics (outside the USA)
Claims enjoined by the FDA

Stops SARS-CoV-2 instantly
One dose lasts 4 hrs. – prevent disease acquisition & transmission

Nursing homes, SNFs, rehabilitation centers

Provide SUPPLEMENTAL IODINE during pregnancy, middle and old age

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PART THREE

Develop Broader Awareness in Medicine

Necessary for proper fetal neurophysiological development
NOTE: Over 2 billion humans are iodine DEFICIENT on earth
Central to I.Q. development
Central to prevention of Cognitive Decline in Adults

This problem affects over 10% of the population 45 & Up
Iodine concentrates in the key cognitive areas of the brain

The only broadbase antiseptic with no record/history of AMR
Difficult to get from what you eat

The iodine cycle from sea🡪clouds🡪earth🡪watering plants 🡪 animals🡪mammal babies has been interrupted due to industrial farming
In milk: completely unplanned, unregulated & adventitious
In fish: problems of plastics and mercury concentrations
Only reliable source: supplementation

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Iodine’s Use in Medicine Today

Povidone Iodine - surgical scrub and/or a surgical prep for sterilizing the skin for a major or minor surgical operation
Invasive procedure like local injection, aspiration or cardiac catheterization
10% solution is used extensively for surgical prep and causes minimal skin irritation
5% betadine (PVP-I) ointment or spray also used for this purpose - an effective antiseptic
Povidone Iodine is used to sterilize the conjunctiva and cornea in the eye for cataract surgery.
Eye wash as a cleansing and antibacterial agent after accidental exposure to potential contaminants.
Used by dentists and oral surgeons to cleanse and sterilize the mucosal lining in the oropharyngeal cavity and on the gums.
It is used by ENT surgeons to cleanse and sterilize the skin and mucosa in the nose and nasopharynx.
Urologists and OBGYNs use Povidone Iodine solution or ointment to apply to urogenital skin and mucosa as a sterilizing and antibacterial agent.

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Iodine’s Use in Medicine Today II

Vaginal douche by women
Intraoperatively: Extensively used by general surgeons to cleanse and wash heavily contaminated peritoneal cavity due to general peritonitis resulting from perforated viscus.
Surgeons cleanse cut edges of the transected bowel with Povidone Iodine soaked swabs to clean and sterilizing before re-anastomosis
This ensures good healing and minimize the chances of local infection and anastomotic leak.
Thoracic surgeons wash pleural cavity with Povidone Iodine solution after pulmonary and esophageal resections and clean cut edges of bronchii and esophagus with betadine before performing anastomosis.
In case of empyema or subphrenic abscess they use copious amounts of Povidone Iodine solution to clean and disinfect these cavities after proper drainage.
During pulmonary resections they frequently use betadine soaked gauze to temporarily cover the cut surface of the lung.
10% Povidone Iodine solution causes no chemical injury to the cut surface of the pulmonary parenchyma or pleura.
Iodine has strong bactericidal, sporicidal, fungicidal, protozoacidal and virucidal properties. Most organisms are killed within 10 minutes by a 0.0002% solution and in 10 seconds by 1%

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Sales/Economic Iodine Use Problems

Too cheap
Not easily patented
Cannot therefore support expensive pharmaco sales
Far too effective

Topically
Intraperitonially
Orally
Supplementally

Only drugs which require continuous use are of interest in the current environment

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Iodine Opportunities

A 1% solution is far more antimicrobial than a 10% solution. REALLY? Yes.
In PVPI, iodine is complexed with the pyrrolidone nitrogen of polyvinyl-pyrrolidone.
10% povidone-iodine contains 1% available iodine

Free iodine conc. is 8 micro moles (0.001%
Diluted to 1%, the free iodine conc. is 80 micro moles
Due to dissociation of the complex.
Bactericidal activity is higher at !% than at 10% concentration.
Ergo: Most of our products use 1% PVPI

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Iodine & I.Q.

In 1950, American women were consuming over 300 mcg/iodine daily
In 1950, America was #1 in World I.Q.
In 2020, American women were consuming under 116 mcg/iodine daily. AND….
16% - 30% consumed under 90 mcg/day
In 2020, America was #26 in world I.Q.
Many clinical studies call this “an emergency”

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In Summary…

Iodine is essential to animal, insect & plant life
Iodine is critical to cognitive efficiency
Insufficient iodine causes numerous illnesses

Poor I.Q. and adult cognitive decline
Bad behavior leading to antisocial attitudes
Increased CVD, diabetes and thyroid disease
Increased parasitic residence
Decreased anti-neoplastic biochemistry

America is in an iodine deficiency crisis