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Fat Burning

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Starvation/fasting

Glucose

Glycogen

Glycolysis, TCA, ETC

Energy (ATP)

Glucose

Glycolysis, TCA, ETC

ATP

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Starvation/fasting

Hydrolysis

TCA cycle & ETC

ATP

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Oxidation

Fatty acid oxidation

It is a process by which fatty acids are broken down into acetyl coA for ATP production

8 molecules

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Types of oxidation

α

β

ω

1

2

n

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Location - mitochondira

Fatty acids

Mitochondria

Fatty acids

Acetyl coA

Cytosol

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Fatty acid oxidation

  1. Activation of fatty acids
  2. Transport of fatty acyl-CoA from the cytosol into mitochondria
  3. β-Oxidation of even-chain fatty acids

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Activation of fatty acids

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Transport of fatty acyl-CoA from the cytosol into mitochondria

Cytosol

Mitochondria

M Membrane

Fatty acyl coA

Acyl Carnitine

Fatty acyl coA

Carnitine

Carnitine

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Acetyl coA

TCA cycle and ETC

ATP

Free fatty acids

Beta oxidation

Summary

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Complete palmitic acid oxidation

7 NADH + 7 FADH2 + 8 acetyl-CoA in 7 cycles

One acetyl-CoA yields

3 NADH + 1 FADH2 + 1 GTP (=ATP) in TCA cycle

Eight acetyl-CoA yields

24 NADH + 8 FADH2 + 8 GTP (=ATP) in TCA cycle

Beta oxidation + TCA cycle

31 NADH + 15 FADH2 + 8 GTP (=ATP) in TCA cycle

Total ATP production

NADH 31 × 3 = 93 (Activation uses 2ATP)

FADH2 15 × 2 = 30

GTP 8 × 1 = 8

Total = 131. Net ATP = 131 - 2 = 129