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CSIR-800

Societal Programme Presentation

On Topic

“Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications”

Presented By

Dipshikha Gogoi

PhD Scholar (biological sciences), CSIR-NEIST

Enrollment No.  10BB22A38006

Team Members, CSIR-NEIST

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    • Devpratim Koch 10BB22J38009
    • Kangkana Chutia 10CC22A38007
    • Bhaben Sharmah 10CC22J38003
    • Rintumoni Paw 10CC22J38006 

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Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

Introduction:

  • Alpinia nigra is a medium-sized herb belonging to the family Zingiberaceae.
  • The species is mainly distributed in India, Andaman & Nicobar Is., Bangladesh, China, Myanmar, Nepal, Sri Lanka, Thailand.
  • The medicinal properties of the species may be beneficial for society in various prospects.

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Rhizome

Stem

Flower

Leaf

Folklore applications

IUCN status

Associated species

  • Bamboo
  • Ferns
  • Curcuma longa
  • Orchids

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Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

Objectives

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  1. Survey and collection of A. nigra from Pukia, Silapathar Assam, India.
  2. Phytochemical investigation an in-vitro antioxidant and antibacterial activity from leaf, stem, and rhizome of A. nigra.
  3. To perform molecular docking, ADMET calculations, Physicochemical Property Calculations, Biological Activity and Adverse Effect.
  4. To generate QR code.

Quick Response (QR) codes are two-dimensional barcodes that store information in both horizontal and vertical directions.

Scanning of QR code

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Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

WET LAB METHODOLOGY

Fig.1. Schematic representation of antibacterial assay

Fig.2. Schematic representation of antioxidant assay

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Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

  • Molecular Docking: This will be done by using Auto-dock Vina to validate the protein and compound interactions.
  • ADMET stands for Absorption, Distribution, Metabolism, Excretion, and Toxicity. This prediction will be done by using ADME Lab 2.0.
  • Physicochemical properties calculations can be done by using RD-Kit
  • Biological Activity and Adverse effect will be done By using PASS ONLINE tool.
  • By using python code the QR code will be generated.

IN-SILICO EXPERIMENTS

MOLECULAR DOCKING

ADMET

PHYSICOCHEMICAL PROPERTY

BIOLOGICAL ACTIVITY & ADVERSE EFFECT

QR Code

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Expected Outcome

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1. Generation of baseline data on the conservation status of A.nigra in Assam, aiding in future conservation efforts and management strategies for the species.

2. Providing insights into its potential as a source of antimicrobial agents.

3. To elucidate the intricate mechanisms underlying drug interactions with biological systems, facilitating a deeper understanding of drug effects and kinetics to optimize therapeutic interventions and minimize adverse outcomes.

4. The goal of the current work is to combine data from in-silico and wet lab experiments onto a unified platform, experiments onto a unified platform, represented by a QR code specific to A. nigra.

Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

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Title: Alpinia nigra (Gaertn.) Burtt: Therapeutic potentials and folklore applications

Applications of A. nigra

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  • It is believed to have spiritual significance and is used as an offering to deities or spirits in religious ceremonies and festivals.
  • In traditional medicine, A. nigra has been used for its medicinal properties.
  • Ropes prepared from A. nigra are also used to tether cows to prevent infestation of diseases and to repel disease vectors.
  • A. nigra contains various bioactive compounds, including flavonoids, terpenoids, and phenolic compounds, which have attracted interest from researchers for their potential pharmacological properties.

Societal Benefits

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  • Sustainable Short-term packaging.
  • It enhancement of self-life of certain products.
  • Drug Repurposing.

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REFERENCES:

  • Sahoo, S., Ghosh, G., Das, D., & Nayak, S. (2013). Phytochemical investigation and in vitro antioxidant activity of an indigenous medicinal plant Alpinia nigra BL Burtt. Asian Pacific journal of tropical biomedicine, 3(11), 871-876.
  • Roy, B., Swargiary, A., & Giri, B. R. (2012). Alpinia nigra (Family Zingiberaceae): An anthelmintic medicinal plant of north-east India. Adv Life Sci, 2(3), 39-51.
  • Ahmed, A. A., Sharmen, F., Mannan, A., & Rahman, M. A. (2015). Phytochemical, analgesic, antibacterial, and cytotoxic effects of Alpinia nigra (Gaertn.) Burtt leaf extract. Journal of traditional and complementary medicine, 5(4), 248-252.
  • Sharmen, F., Mannan, A., Rahman, M. M., Chowdhury, M. A. U., Uddin, M. E., & Ahmed, A. A. (2014). Investigation of in vivo neuropharmacological effect of Alpinia nigra leaf extract. Asian Pacific Journal of Tropical Biomedicine, 4(2), 137-142.

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