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Welcome to the CURE-KY Monthly Gathering 11/5/2025

Tentative Schedule�🕓 4:00–4:45 PM – Arrive, grab food, and settle in�🧠 4:45–5:15 PM – One-slide Lab Presentations on Respiratory Health�💬 5:15–6:00 PM – Network and Collaboration Planning

Calendar Updates

No Cornerstone meeting in December!

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The next Cornerstone gathering is

January 7th

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Theme: Artificial Intelligence in Research

Presentation Order:

1. Dr. Lutz Goehring –

CAFÉ

2. Dr. Kathleen Winter –

CPH

3. Dr. Saurabh Chattopadhyay CoM

4. Dr. Rebecca Dutch –

CoM

5. Drs. Li and S. Chattopadhyay CAFÉ/CoM

6. Dr. Julian Porras-Villamil – CAFÉ

7. Dr. Ilhem Messaoudi –

CoM

8. Dr. James Brien –

CoM

9. Dr. Ishanu Chattopadhyay – CoM

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Equid alphaherpesvirus -1 and -4

Equid gammaherpesvirus -2 & -5

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… and because of a post-viremic, paralytic

neurologic syndrome (EHM)

EHV-1

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  • surveillance and early detection
  • dose and infection (low-med-high)
  • deposition studies (upper vs lower respiratory tract)
  • airborne transmission studies – immune system priming – sentinel exposure

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  • latency and reactivation – transcriptomics
  • EHV-1 latency modeling

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  • (mRNA vaccine testing)

Team Herpes @Gluck, MG CAFÉ

Lutz S Goehring (L.Goehring@UKy.edu)

Horse DRG

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Kentucky Department for Public Health

We have statewide KY data!

  • Flu, COVID, RSV
  • TB
  • Legionella
  • Vaccine-preventable diseases
  • Kentucky Immunization Registry

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  • Electronic laboratory reports
  • Clinical case reports & public health investigation records
  • Hospital discharge (ESSENCE)
  • Death certificate
  • KDPH Data Resource Guide

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3

kathleen.winter@ky.gov

State Epidemiologist/Director, Division of Epidemiology & Health Planning, KDPH

Associate Professor, Department of Epidemiology & Environmental Health, UK College of Public Health

Kentucky Department for Public Health

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Innate immune responses to control respiratory viral infection and inflammation

Increased lung immunopathology in the absence of IRF3

  • Cell-specific regulation of these IRF3 pathways
  • Knock-in mice defective in specific pathways

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  • Develop lung organoid models to study these pathways
  • Translate these studies to human respiratory infections

Minutes to hours post-infection

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The Dutch Laboratory: Understanding the Molecular Details of Respiratory Viral Disease

Systems studied (infectious virus):

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HMPV

RSV

HPIV-3

PIV5

Cedar Virus

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Systems studied (Transfection only):

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Hendra virus

Nipah virus

SARS-CoV-2

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Approaches:

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Cell Biological Assays of different stages of infection

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Biochemistry and Biophysical approaches

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Human airway epithelial models of infection

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  • Pathogen Surveillance: investigate how pathogens infect, evolve, and transmit in the animal-human-environment interface
  • Host Response: immune response to vaccination and infection
  • Control Measure: new and improved therapeutics and vaccines
  • Artificial Intelligence: modeling the evolution and epidemiology of pathogens in the animal-human-environment interface
  • Seeking collaborators: clinical research, epidemiology, immunology, virology, ecology, molecular systematics, bioinformatics, computational biology.
  • Feng Li (M-G CAFÉ) and Saurabh Chattopadhyay (COM)

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Airborne Disease Interest Group

at OH Center,

Martin-Gatton College of Agriculture, Food and Environment

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HUMAN HEALTH BURDEN OF URBAN PESTS

Relation of cockroach control with health and Asthma outcomes

Bed bug infestations and pulmonary health and immune reactions

Associations between Urban Pests and Human Microbiome

Bed bug clinical (medical and psychological) manifestations

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Studies in the Messaoudi Lab

  • Ongoing Projects
    • Cellular, humoral and transcriptional responses to Nontuberculous mycobacteria pulmonary infection – macaque animal model
    • Mechanisms of virulence of varicella zoster virus (VZV) infection

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  • Technical Skills
    • ELISA, ELISpot, Luminex
    • Cellular phenotype by flow cytometry
    • Bulk and single cell RNA Seq
    • 16S rRNA sequencing
    • Lung organoids

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messaoudilab.com

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Prolonged SARS-CoV-2 infection after treatment with Bamlanivimab leads to generation of novel, potential escape mutants

Infectious Diseases and Vulnerable Populations- (HSCT)

Brien lab

j.brien@uky.edu

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