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Metabolism

Lesson 1.2: Welcome to Medical School

Lesson purpose: to help students begin to make connections between macro-effects, such as how tired someone feels, and the microscopic world of metabolism—the body’s use of molecules for energy and growth

Please refer to this lesson’s Materials & Preparation section in the digital Teacher’s Guide or the print Teacher’s Guide for information about preparing to teach this lesson, including any applicable safety notes. Below are links to resources used in this lesson.

Metabolism Simulation

Completed Scientific Argumentation Wall Diagram

Metabolism Investigation Notebook, pages 5–8

Printable Metabolism Glossary

Printable Metabolism Multi-Language Glossary

Metabolism Glossary

Metabolism Multi-Language Glossary

Note: These materials are made available exclusively for use by students and teachers for whom the corresponding materials have been purchased or licensed from Amplify. Any alterations you make should only be shared within your own school or district. Any other distribution or reproduction of these materials is forbidden without written permission from Amplify.

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Activity 1

Metabolism: Lesson 1.2

Today, we will begin a new unit called Metabolism.

We will start with a Warm-Up each day to get us thinking about science ideas. For today’s Warm-Up, you will watch and respond to a video that introduces your new role as medical students.

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Activity 1

Metabolism: Lesson 1.2

Investigation Notebook pg 6

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Activity 2 - Screen 1

Metabolism: Lesson 1.2

A lot of things that happen in the human body are hidden or too small to directly observe. We will use a simulation to help us learn more about how human body systems function.

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Activity 2 - Screen 1

Metabolism: Lesson 1.2

This simulation is called the Metabolism Simulation. It’s a scientific model of the human body that simulates many things that happen inside the human body.

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Metabolism: Lesson 1.2

Investigation Notebook pg 7

Activity 2 - Screen 1

Open the metabolism sim

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Metabolism: Lesson 1.2

Activity 2 - Screen 1

What did you notice about the Sim?

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Metabolism: Lesson 1.2

Activity 2 - Screen 1

To figure out why Elisa feels so tired, we will first think about healthy bodies.

What are some things you know the human body needs to function?

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Metabolism: Lesson 1.2

Activity 2 - Screen 1

What are signs you can observe when a human body is functioning properly?

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Activity 2 - Screen 2

Metabolism: Lesson 1.2

As we discussed, there are certain things we already know the human body needs to function. Two important things the human body needs to survive are food and air.

As you explore the Metabolism Sim again, watch what happens to the food and air that enter this healthy Simulation body.

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Metabolism: Lesson 1.2

Investigation Notebook pg 7

Activity 2 - Screen 2

Observe the Sim a second time.

This time, watch what happens to the food and air that enter this healthy Simulation body.

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Metabolism: Lesson 1.2

Activity 2 - Screen 2

What happens to the food and air that enter this healthy Simulation body?

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Unit Question

Activity 2 - Screen 3

Metabolism: Lesson 1.2

How do the trillions of cells in the human body get what they need to function, and what do the cells do with the things they absorb?

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Chapter 1 Question

Metabolism: Lesson 1.2

Activity 2 - Screen 3

Why does Elisa feel tired all the time?

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Metabolism: Lesson 1.2

Activity 2 - Screen 3

The yellow box represents one cell in this model of the healthy human body. You can zoom into this cell by pressing on the cell and then on the magnifying glass.

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Metabolism: Lesson 1.2

Activity 2 - Screen 3

The trillions of cells in the body have some similarities in the ways they function, so we can learn more about what all cells need by observing one cell in the Simulation.

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Metabolism: Lesson 1.2

Investigation Notebook pg 7

Activity 2 - Screen 3

Observe the Sim again.

This time, pay attention to what’s happening in the representative cell to learn more about what cells in the body need.

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Metabolism: Lesson 1.2

Activity 2 - Screen 3

Which molecules are entering the cell?

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Vocabulary

Activity 3

Metabolism: Lesson 1.2

the body’s use of molecules for energy and growth

metabolism

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Activity 3

Metabolism: Lesson 1.2

In the Sim, you observed that in a functioning, healthy body, certain molecules that come from food and air are transported into the body’s cells.

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Activity 3

Metabolism: Lesson 1.2

Claims

Elisa is feeling tired because she:

Remember the claims we generated about why Elisa is feeling tired.

Do you have any new insights or changes in thinking about these claims after observing the Sim?

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Activity 3

Metabolism: Lesson 1.2

The Metabolism Sim �can help us investigate if Elisa’s problem is related to the molecules she is taking in from the environment and/or what is happening in the cells in her body.

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Homework

Metabolism: Lesson 1.2

Activity 4

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Activity 4

Metabolism: Lesson 1.2

For this activity, you will experiment with different diets in the Sim to see how the diet affects the number of molecules getting to the cells. Then, you’ll record your results.

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#2

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#3

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Metabolism: Lesson 1.2

End of Lesson

Published and Distributed by Amplify. www.amplify.com

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Metabolism

Lesson 1.3: Evaluating Initial Claims About Elisa

Lesson purpose: to give students practice with important aspects of scientific argumentation, such as critiquing evidence, while also helping them rule out several explanations for Elisa’s problems

Please refer to this lesson’s Materials & Preparation section in the digital Teacher’s Guide or the print Teacher’s Guide for information about preparing to teach this lesson, including any applicable safety notes. Below are links to resources used in this lesson.

Metabolism Modeling Tool: 1.3 Molecules in a Cell

Metabolism Sorting Tool: 1.3 Evaluating Evidence

Scale Tool

Molecules Cells Need

Printable article: "Molecules Cells Need"

Annotation Tracker Instructions

Active Reading Guidelines

Annotation Tracker

Annotation Summary Sheet

Example Annotation Trackers and Summary Sheet

Metabolism Investigation Notebook, pages 9–18

Metabolism Glossary

Metabolism Multi-Language Glossary

Note: These materials are made available exclusively for use by students and teachers for whom the corresponding materials have been purchased or licensed from Amplify. Any alterations you make should only be shared within your own school or district. Any other distribution or reproduction of these materials is forbidden without written permission from Amplify.

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Modeling Tool

5 MIN

Metabolism: Lesson 1.3

Open the Warm up 1.3

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What did your model look like or include?

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Activity 2 - Screen 1

Metabolism: Lesson 1.3

In the Sim, we observed that in a healthy body, cells get certain molecules from food and air. Let’s review some of the words we saw in the Sim and their definitions.

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Vocabulary

Metabolism: Lesson 1.3

Activity 2 - Screen 1

a group of atoms joined together in a particular way

molecule

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Vocabulary

Metabolism: Lesson 1.3

Activity 2 - Screen 1

a molecule that organisms can use to release energy, and that is made of carbon, hydrogen, and oxygen atoms

glucose

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Vocabulary

Metabolism: Lesson 1.3

Activity 2 - Screen 1

a molecule that organisms get from the air or water around them and use to release energy

oxygen

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Vocabulary

Metabolism: Lesson 1.3

Activity 2 - Screen 1

molecules that are the building blocks of proteins

amino acid

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Reading "Molecules Cells Need"

15 MIN

Metabolism: Lesson 1.3

Open the article titled:

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Discussing Annotations

Metabolism. Lesson 1.3

Activity 2 - Screen 1

1. Prepare to Share�Choose an interesting question or connection to share with a partner. ��Tag it with #share.

2. Discuss�Talk about your chosen annotation with a partner. ��Tag it with #discussed if you were able to resolve your questions.

#share

#discussed

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Metabolism: Lesson 1.3

Activity 2 - Screen 1

Where does the body get each of these molecules?

glucose molecules
amino acid molecules
oxygen molecules

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Metabolism: Lesson 1.3

Activity 2 - Screen 1

What do you think could happen if the human body doesn’t take in one or all of these molecules?

Why do you think this?

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Activity 3

Metabolism: Lesson 1.3

Before we can diagnose Elisa, we need to understand more about what’s happening in a healthy body. We’ll make models to show which molecules are found in a healthy cell.

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Activity 3

Metabolism: Lesson 1.3

We’ll use a digital tool called the Metabolism Modeling Tool.

Scientists often use models to work out their ideas and share them with others.

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Modeling Molecules in a Healthy Cell

5 MIN

Metabolism: Lesson 1.3

Open the:

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What did your model look like or include?

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Key Concept

Activity 3

Metabolism: Lesson 1.3

A functioning human body has molecules from food (glucose and amino acids) and molecules from air (oxygen) in its cells.

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Evaluating Evidence

Activity 4 - Screen 1

Metabolism: Lesson 1.3

With more data, you can trust the patterns that you see.

We will use this criterion to evaluate evidence.

Evidence is higher quality when it is based on more data because there can be more confidence in the patterns seen in the data.

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Metabolism: Lesson 1.3

Investigation Notebook pg 13

Activity 4 - Screen 1

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Metabolism: Lesson 1.3

Activity 4 - Screen 1

Which piece of evidence is higher quality?

Which piece of evidence is lower quality?

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Metabolism: Lesson 1.3

Activity 4 - Screen 2

Next, you’ll work with a partner in the Metabolism Sorting Tool. You’ll evaluate some evidence from Elisa based on how much data was collected.

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Metabolism: Lesson 1.3

Activity 4 - Screen 2

I’ll post the Evidence Cards on the Evidence Gradient as we discuss them.

Let’s evaluate the evidence together.

Where did you place each card?

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Activity 5 - Screen 1

Metabolism: Lesson 1.3

Claims

Elisa is feeling tired because she:

is not getting enough sleep.
is not eating enough food or not eating the right foods.
has a medical condition.

Let’s use what we’ve learned about healthy bodies and the evidence from Elisa’s journals to reconsider the claims about why Elisa feels tired.

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Metabolism: Lesson 1.3

Investigation Notebook pg 15

Activity 5 - Screen 1

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Activity 5 - Screen 2

Metabolism: Lesson 1.3

It looks like lack of sleep and poor eating habits do not explain Elisa’s tiredness.

Going forward, we’ll focus on whether Elisa has a medical condition that could be preventing the necessary molecules from getting to her cells. This might explain why she feels so tired.

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Homework

Metabolism: Lesson 1.3

Activity 6

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Activity 6

Metabolism: Lesson 1.3

For this activity, you will think about the size of different molecules in the body and respond to some questions.

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Activity 7

Metabolism: Lesson 1.3

For this activity, you will have a chance to reflect on your learning so far.

You will revisit these questions at the end of every chapter.

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Metabolism: Lesson 1.3

End of Lesson

Published and Distributed by Amplify. www.amplify.com