1 of 11

NEURAL DYNAMICS OF PRIOR UPDATING ACROSS MOUSE MODELS OF AUTISM

Jake Pennington | Nicole G.-Rangel

neurodata rehack 2026

2 of 11

Shared computational signature despite this diversity: ASD models update priors more slowly, with encoding shifting from sensory → frontal cortex

(Noel et al. 2025)

is this a difference in what is represented, or in how fast/stably it's reached?

3 of 11

Thanks Pranav!

4 of 11

5 of 11

No bias

Right-biased

6 of 11

7 of 11

Distribution of population activity across 2d projection

8 of 11

Fmr1

Cntnap2

Shank3b

Wildtype

9 of 11

10 of 11

11 of 11

Thank you!