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Model Organisms and Biological Databases

Lab 9

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Lab Project Overview

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C-MOOR Science Project

1.Formulate a scientific hypothesis

2.Design an analysis of RNA-seq data to answer a scientific question

3.Analyze results to form conclusions

4.Effectively communicate findings through graphs and in writing

5.Identify primary and secondary literature in science

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Bioinformatics

In the next two labs, we will be analyzing large data sets from Marianes and Spalding 2013 using bioinformatics.

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Bioinformatics combines biology, computer science, mathematics and statistics to analyse and interpret biological data

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Over the next several weeks, you will work in groups as research scientists to answer an original research question.

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Presenting Your Findings

Scientists communicate their result both formally (publication) and informally (conferences, lab meetings, symposiums, etc.)

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One informal way to present your research is through a Research Poster.

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Example

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Your Group Poster - 30 points

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2.

Lab 9

Model Organisms and Biological Databases

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Learning Goals

  1. Explain the importance of model organisms and identify some of their desirable characteristics.
  2. Describe the usefulness of Drosophila as a model system.
  3. Use online databases to look up information about a gene.

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Image credit: Max Westby. Some of the most important genetic model organisms in use today. Clockwise from top left: yeast, fruit fly, arabidopsis, mouse, roundworm, zebrafish. License: CC ANS 2.5

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Model Organisms

Discuss with your table:

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What are some reasons that drosophila melanogaster is used as a model organism?

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Biological Databases (Activities 1-3)

With your group, work through the three Tutorials in Lab 9 to become familiar with:

    • GenBank
    • OMIM
    • Human Protein Atlas (HPA)
    • PDB
    • FlyBase

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Activity 4 - Research a Gene

Use the databases you learned about to research the gene assigned to you.

Each Table will research the 4 genes with the letter assigned to them.

One student in each group is responsible for one gene.

Table 1

A

Table 2

B

Table 3

C

Table 4

D

Table 5

E

Table 6

F

Table 7

G

Table 8

H

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Activity 5 - Present Your Gene

Take turns presenting your gene to your table.

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Choose one gene that you all agree sounds like an interesting gene to share with the class.

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Activity 6 - Group Mini-Presentation

  1. With your group, create a short presentation to present your chosen gene to the class.
  2. Your presentation should have about four slides and be thorough:
    1. Slide 1: The GENE you picked to share with your group, your name and date
    2. Slide 2 - 4: Present the information you collected about the gene. For full credit, include relevant images/ diagrams on your slides.
  3. One student in the group should post your slides on Canvas to the discussion board. Make sure you mention everyone in your groups by name so they also get credit for the presentation.

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Summary

What we learned..

  1. How model organisms are used in biology research
  2. How to use databases to research a gene.

What’s next..

  1. Post your group presentation on Canvas Discussion Board
  2. Next week: Lab 9: RNA-Seq

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Contributions

This lesson was created by:

Stephanie R. Coffman Ph.D., Clovis Community College

Add Attributions here. Delete if not needed.

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