Irvine 台灣基督長老教會
Irvine, CA
讓我們來討論如何 “及時” 預防
阿茲海默症
Bang H. Hwang, Ph.D.
( 黃邦雄 )
June 17, 2025
Alzheimer’s Disease & its potential pathogenesis: How to prevent this terrible disease in time?
Alzheimer’s Disease :
Two/thirds (2/3) are Female
�
The greatest global challenge for health & social care in the 21th century
- 12 Risk Factors
- Preventable
Gill Livingston et al.
Lancet 380:2673-2734, 2017
Dementia
Alzheimer’s Disease
WHO 2025:
- 55 millions
- $1.3 trillion
- Every 3 seconds
Dr. Alois Alzheimer, 1906
~120 Years
No Any Effective Drugs
Frontal lobe Parietal lobe
Temporal lobe Hippocampus
Amygdala
Amyloid beta Amyloid Plaques
Tau Protein Neurofibrillary Tangles
Dale Bredesen, MD
Former Neurology Professor
UCLA
Buck Institute for Research on Aging Novato, CA
1. Inflammartary 5. Age
2. Atrophic 6. Genetic
3. Toxic 7. Vascular
4. Traumatic 8. Poor Lifestyle
Potential Risk Factors:
1. Inflammatory Risk Factor:
* Inflammation:
A. Infection
B. Injury
C. Irritation (刺激)
A. Infection:
- Fungi - Bacteria - Virus
West Nile Virus:
- Encephalitis - Meningitis
(腦炎) (腦膜炎)
Herpes simplex virus (皰疹病毒)
P. Gingivitis (牙齦炎)
B. Injury:
C. Irritation:
a. Chemicals like tumor necrosis
factor, NO or excess glutamate
b. Radiation including UV light,
Radiation Therapy, X-rays &
CT scans
Inflammatory Risk Factor:
Anti-inflammatory Foods –
- Different berries like blueberries
- Fatty fish - Nuts
- Tumeric - Olive Oils
- Green Tea
- Green leafy vegetables
2. Atrophic Risk Factor:
Deficits of Trophic Factors
in the Brain
(Neurotrophic factors)
(滋養生長的元素)
,
Deficits of :
- Nerve Growth Factor (NGF)
- Brain-Derived Neurotrophic Factor (BDNF)
- Thyroxine
- Insulin
- D3 &
- Estrogen etc ……
,
BDNF: Exercise, Fasting, Manage Stress
Foods that can increase BDNF:
1. Coffee 2. Green Tea,
3. Soybean 4. Dark Chocolate
5. Blueberries
6. Fatty Fish: Eat SMASH ………
Salmon, Mackerel, Anchovies,
Sardines & Herring (鯡魚)
Fatty Fish: Eat SMASH -
3. Toxic Risk Factor:
- Biotoxins
1. Organic Chemical Pollutants:
Pesticides, Insecticides,
Herbicides
Candle – Benzene
Dioxins
a. Metalotoxins - Mercury, Lead,
Aluminum, Asenic, Copper …..
b. Nitrate - Bacon, Ham, Sausage ...
(Nitrosamine - highly carcinogenic)
2. Inorganic Chemical Pollutants:
3. Biotoxins
- Molds (Fungi): Mycotoxins;
Aflatoxins (花生黃麴毒素)
- Homocysteine (同型半胱氨酸)
[Dr. David Smith of Oxford Univ.]
Methionine
Homocysteine
B9
(Folic acid)
CH3
(Methyl)
Methyl
B12
B6
Cysteine
Sulfate
(Methylation)
解毒[Detoxification]DETOX
Homocysteine
Serine
Cysteine
Sulfate
Glutathione
(Antioxidant)
Tri-peptide
解毒[Detoxification]DETOX
To Reduce Homocysteine
Serine –
Eggs, Meats, Fish, Soybeans,
Walnuts, Vegetables, Lentils. Legumes, Whole grains ...
To Reduce Homocysteine
Cysteine:
Eggs, Chicken, Fish, Dairy,
Garlic, Broccoli, Cauliflowers,
Brussels Sprouts, Asparagus .…
To reduce Homocysteine
Glutathione (Tripeptide):
Eggs, Fish, Cruciferous Vegetables, Asparagus, Kale,
Avocado, Papaya, Cucumbers,
Green Beans …
Methionine
Homocysteine
B9
(Folic acid)
CH3
(Methyl)
Methyl
B12
B6
Serine
Cysteine
Sulfate
Glutathione
(Antioxidant)
Tri-peptide
(Methylation)
解毒[Detoxification]DETOX
4. Traumatic Risk Factor:
Different Kinds of Traumas:
- Recurrent Concussions
- American Football Games
- Boxing Sport - Falls
- Auto Collisions - Violence
5. Genetic Risk Factor:
not living a poor lifestyle
6. Age Risk Factor:
- Absolutely, age is a potential risk
factor, since we never have young
persons who will develop the
Alzheimer’s disease.
- Women live 6 years more than men.
7. Cardiovascular Risk Factor:
Major Cause for Alzheimer’s Disease
* Hypertension * High LDL
* Overweight. * In-activity
* Smoking * Poor Diet
* Excessive alcohol consumption
8. Poor Lifestyle Risk Factor:
* Physical Inactivity
* Smoking
* Excessive alcohol consumption
* Staying-Up Late (熬夜)
* Social Isolation/Depression
* Impaired Vision & Hearing
* Poor Dieting
1. Inflammartary 5. Age
2. Atrophic 6. Genetic
3. Toxic 7. Vascular
4. Traumatic 8. Poor Lifestyle
Potential Risk Factors:
How to Prevent Risk Factors:
~ 40
1. 清毒 2. 排毒
3. 運動 4. 舒壓
5. 改善生活習慣
1. 清毒
5% Baking Soda (小蘇打粉)
100 – 5 = 95
1 : 19
浸洗 ~ 10 min
2. 排毒:
A. 大號 (Poo) - 大腸
B. 小號(Pee) - 腎臟, 小腸
C. 流汗 (Sweating) - 汗腺
D. 森林浴 (Forest Bathing)
排毒:
A. 大號 (Poo) - 大腸
100 trillions of Bacteria
- Helicobacter Pylori
- Salmonella
A. 大號 (Poo) - 大腸
Bacteria can break down
foods, toxins, and fibers to
release minerals & vitamins.
Salad (沙拉; 青菜)
In the large intestine (colon, 大腸):
bacteria
(fermentation)
Dietary Fibers
Butyrate
Butyric Acid (丁酸)
- To Provide Energy for
* Bacteria
* Colonocytes (Epithelial Cells )
* Tight Junctions
* Leaky Gut
- To Nurture T Cells for Immunity
Butyric Acid (丁酸):
Anti-cancer Property for
Colorectal Cancer (大腸癌)
賀一航 64 豬哥亮 70
楊德昌 59 陳萬水 72
Butyric Acid (丁酸):
Inhibition of Liver Cancer Cells
(肝癌細胞)
H. Yamamoto et al. Int. J. Cancer 76:
897- 902, 1998.
H. G. Wang et al. Int. J. Molecular Medicine, Feb. 23, 2013
- 水牛 (Water Baffulos)
- 烏龜 (Sea Turtles)
B. 小號 (Pee) - 腎臟, 小腸
- 飲食, 消化, 吸收, 血液
- 60 秒
- 排尿
- 利尿: 水, 咖啡因 (Coffeine)
喝咖啡的優點
咖啡因 (Coffeine):
Diuretic Effect
Lower Blood Pressure
(Hydrochlorothiazide 利尿劑)
喝咖啡的優點
Chlorogenic Acid (綠原酸) :
Polyphenol: BDNF
享受喝咖啡 :
- Sugar: The Bitter Truth (UCSF, 2009)
Poison
- Sugar is Toxic (Dr. Robert Lustig,
The Science Times, Nov. 5, 2015)
糖 是比 “古柯鹼” (Cocaine)
更加厲害的毒品
(蔡凱宙醫師)
有什麼東西比 “糖” 更毒的?
Fructose (果醣)
Fructose
(gluconeogenesis)
Glucose
(lipogenesis)
Fat
Fatty Liver
(脂肪肝)
Fructose (果醣)
- Increase Ghrelin Secretion
from the Stomach to increase
Hunger
- Faciliate Orexin Secretion
Fructose (果醣)
- Inhibition of Protein Synthesis
- Sarcopenia (肌少症)
洪永祥 醫師
10種破壞腎臟食物
“排行榜”
洪永祥 醫師
3. 炸雞排
洪永祥 醫師
2. 日本拉麵
洪永祥 醫師
1. 珍珠乳茶
果醣
C. 流汗 (Sweating) - 汗腺
Metalotoxins:
- Mercury - Lead,
- Aluminum - Asenic,
- Copper .....
D. 森林浴 (Alpine Forest Bathing)
- To exhale: CO2
- To Inhale: O2 and Phytoncides (芬多精)
How to Prevent Risk Factors:
~ 40
1. 清毒 2. 排毒
3. 運動 4. 舒壓
5. 改善生活習慣
3. Exercise (運動)
- BDNF - Sweating
- Stress - Stem Cells
(幹細胞)
4. 舒壓
- Well Manage the Stress
- 健康最大的殺手是精神壓力
- 舒解壓力是非常重要:
- 作 ”流大汗” 的運動 (Exercise)
- 書法寫字
- 繪畫
- 唱歌, 跳舞 ……..
Poor Lifestyle Risk Factor:
* Physical Inactivity * Smoking
* Excessive alcohol consumption
* Staying-Up Late (熬夜)
* Social Isolation/Depression
* Impaired Vision & Hearing
* Poor Dieting
5. 改善生活習慣
活的健康的重要原則:
三多二少一不 :
* 多運動 * 少吃飯
* 多喝水 * 少熬夜
* 多休息 * 不抽煙
5. 改善生活習慣
Poor Dieting (飲食不當)
You are what you eat. (Jean Brillat-Savarin, French Gastroneme)
“食多” 肥胖
Obesity is one of important contributors to Alzheimer’s disease or Dementia.
地中海飲食:
橄欖油, 大量 蔬菜, 豆類, 堅果, 全穀類, 海鮮, 鷄肉, & 鷄蛋.
生酮飲食 (Ketogenic Diet):
極低澱粉, 高脂肪 & 中等蛋白質的飲食方式.
生酮飲食 (Ketogenic Diet):
極低澱粉, 高脂肪 & 中等蛋白質的飲食方式.
(脂肪: 主要能量來源)
生酮飲食 (Ketogenic Diet):
- Fat 60% (脂肪)
- Protein 35% (蛋白質)
- Carbo 5% (澱粉)
Extra-virgin Olive Oils
(特級初榨 橄欖油)
Fatty Acids
Ketone Bodies (酮體):
Ketogenesis
- Acetone (丙酮)
- Acetoacetate (乙醯乙酸)
- Beta-hydroxy butyrate
(氫氧丁酸)
適合 生酮飲食的人:
• 想減重的人
• 第 2 型糖尿病患者 (需醫生監督)
• 有胰島素抗性的人
不適合 生酮飲食的人:
• 肝病 腎病患者
• 長期高強度運動員 (需調整)
• 孕婦 & 哺乳期女性 (需醫生
評估)
- Obesity is considered a
major global epidemic.
俗話說: 肥胖是百病之源
ChatGTP: Obesity is a major
global health issue.
Obesity: Fats (Fatty Acids)
Starvation or Fasting
Glucose Fats
(LIVER)
Lipogenesis
Gluconeogenesis
“Starvation as a Therapy”
(Editorial, Journal of American Medical Assoc. 92. #14, 1929)
“Fasting (斷食) is a therapy for obese persons”
A 456-lb Scottish patient (Angus Barbieri) fasted for
“1 year & 17 days” to successfully lose 276 lbs.
(W.K. Stewart & L.W. Fleming, Postgraduate Medical Journal 49: 203-209, 1973)
Advantages of
Fasting
* Simplicity
* Free: No Cost
* Convenience: No Shopping/
Cooking/Cleaning/Eating
* Freedom: Free from Diseases
& Cancers
Fasting induces Autophagy (自噬):
- Produce “Amino Acids”
“Glucose”
Gluconeogenesis
Dr. Yoshinori Ohsumi (大隅良典)
Nobel Prize in Medicine, 2016
“Yeast”
Starvation or Fasting
Autophagy (自噬)
A Key to Good Health & Longevity
Intermittent Fasting
(間歇性的斷食)
(the 16:8 approach)
- 16-hr Fasting for Autophagy
- Glymphatic System Cleaning
- 最好的減肥方法就是 “食少”
- Calorie Restriction (吃 六份飽):
Lifespan 2X (Clive McCay et
al., Scientific Monthly 39:
405 - 414, 1934)
- Eating too much of anything
is bad (Mark Twain).
- 中庸之道 (孔子公, 2500 年前)
Life is like riding a bicycle.
To keep your balance, you must keep moving.
(Albert Einstein)
1. Inflammartary 5. Age
2. Atrophic 6. Genetic
3. Toxic 7. Vascular
4. Traumatic 8. Poor Lifestyle
Potential Risk Factors:
~ 40 years old of age
How to Prevent Risk Factors:
~ 40歲
1. 清毒 2. 排毒
3. 運動 4. 舒壓
5. 改善生活習慣
保證不會得到
失智症
或
阿茲海默症
顧好 “健康”
卡贏 “百萬富翁”
顧好 “身體”
顧 “台灣”
多謝