IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars

March 31, 2022

Welcome - The meeting will start at 3PM ET

NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND

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Agenda

1. Welcome
2. Links, people, other info
3. Social media links
4. Quick Announcements
5. Upcoming Mini-Seminars and Request for Future Speakers
6. Open discussion on Future Directions of the WG, moderated by James Glazier and Reinhard Laubenbacher
7. Request for Further Business

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People

Co-Lead: Reinhard Laubenbacher, PhD

Department of Medicine

Laboratory for Systems Medicine

University of Florida

reinhard.laubenbacher@medicine.ufl.edu

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Co-Lead: James A. Glazier, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jaglazier@gmail.com

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Web Administration, Slack: James P. Sluka, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jsluka@indiana.edu

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Activities Coordination: Lorenzo Veschini, PhD

King’s College London

lorenzo.veschini@gmail.com

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Slack Channel

https://Msm-working-group.slack.com

Twitter

https://twitter.com/MsmViral

Our IMAG/MSM Wiki page

https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!

Or, use the Tiny URL: https://tinyurl.com/hkr97vfe

IMAG’s LinkedIn

https://www.linkedin.com/groups/12095434?lipi=urn%3Ali%3Apage%3Ad_flagship3_search_srp_all%3B1FVndkN2SD6P0xj2PYfqdQ%3D%3D

YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd

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Please follow the�group on Twitter!

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https://twitter.com/MsmViral

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If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.

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Announcements

�Any short (~1 minute) items such as;

• announcements
• meetings
• funding
• publications
• requests for help

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WG Steering Group tomorrow at 11AM

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Schedule for Upcoming Meetings and mini-Seminars

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April 7:

1. Jonas Hue, King’s College
2. Yuefan Deng, Stonybrook, “Multi-scale and Machine Learning Algorithms for Modeling Large Blood Clots”

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April 14:

1. Natasha Diba Sheybani, University of Virginia
2. TBD

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Request for future speakers (April 14, …)

Mini-Seminar�Discussion on Future Directions of the WG

Moderated by�James Glazier and Reinhard Laubenbacher�

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• Update on WG and other activities.
• Discussion of Seminars and request for ideas for speakers and topics.
• Report on Steering Group discussions about a broader organizational structure around predictive/computational immunology, including the connection between individual and environment.
• Discussion about broadening membership.
• General discussion about challenges/opportunities related to computational immunology.

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History and Status

Proposed July 2020

First Meeting October 22, 2020

>110 Seminars

>200 Members, of whom ~30 are regularly active

Several active subgroups

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• Using digital twins in viral infection, Laubenbacher R, Sluka JP, Glazier JA, Science 371: 1105-1106. doi: 10.1126/science.abf3370, 2021.
• Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response, Zarnitsyna VI, Gianlupi JF, Hagar A, Sego TJ, Glazier JA, Current Opinion in Virology 50, 103-109, doi: 10.1016/j.coviro.2021.07.007, 2021.
• Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility, Karr J, Malik-Sheriff RS, Osborne J, Gonzalez-Parra G, Forgoston E, Bowness R, Liu Y, Thompson R, Garira W, Barhak J, Rice J, Torres M, Dobrovolny HM, Tang T, Waites W, Glazier JA, Faeder JR and Kulesza A, Front. Syst. Biol. 2:822606, 2022.
• Building Digital Twins of the Human Immune System: Toward A Roadmap, R. Laubenbacher, A. Niarakis, T. Helikar, G. An, B. Shapiro, R. S. Malik-Sheriff , T.J. Sego, A. Knapp, P. Macklin, J. A. Glazier, npj Digital Medicine, in press, 2022.

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• Others in preparation, under review

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• Please let us know about any papers you have published or are preparing that grew out of WG connections

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Some WG Associated Publications

New subgroup: Building immune digital twins

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20+ members

Goal: Develop a “wedding planner” for IDT construction

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Completion: end of year 2022

Publicity:

• Omaha World-Herald (Tom Helikar)
• ACM News (Reinhard Laubenbacher)

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See website for more accomplishments

New Projects

Precision Immunology: Building an Immune Digital Twin

3-day workshop, 20-30 participants

University of Florida, November 2022

Supported by U.S. Department of Defense

Grant Nr. ACC- APG- RTP W911NF

PI: Laubenbacher

Building an Immune Digital Twin

3-week workshop, 60-100 participants

Institut Pascal, Paris, Spring 2023

Supported by Institut Pascal, Paris, France

PIs: Niarakis, Laubenbacher

Building an Immune Digital Twin (tentative)

Leiden

Tentative Pis: Glazier, An, Veschini,?

Chan-Zuckerberg grant proposal on predictive immunology

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Glazier

Planned Conferences, Workshops, Grants

Please let us know about any conferences or grants you are preparing that grew out of WG connections

• Please suggest ONE speaker NOW

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• Breadth of topics? Missing Topics?
• Format?

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• Better ways to publicize and distribute videos?

Discussion of Seminar Series

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• Lack of funding for admin support/infrastructure/activities

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• Narrow focus and title of WG (viral pandemics vs immune response or pathogenesis more broadly) may limit membership/activities

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Working Group Challenges

• Lack of funding for admin support/infrastructure/activities

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• Narrow focus limits membership/activities

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Discussion of Working Group Challenges

Possible Solution: Establish an umbrella organization

Consortium for Predictive Immunology which could include the current WG as a member

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Consortium members can be individuals and organizations, e.g., universities, the Working Group, professional societies, companies, etc.

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Possible advantages: Broader focus and more accurate title could attract more participants, possible funding recipient, better match to developing activities

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Suggestions for other ways to increase membership, engagement and participation?

Requests for Input/Suggestions

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We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present

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Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite

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Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively

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There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions

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Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues

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