MH CART UPDATE 2021

Go Live 2/1/2021

OVERVIEW OF CHANGES EFFECTIVE 2/1/2021

Conversion from Dantrium to Ryanodex

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Implementation of MH Documentation Form

CONVERSION TO RYANODEX

• What is Ryanodex?
• Ryanodex is a newly formulated dantrolene. It uses nanosuspension technology which allows rapid reconstitution and administration. Dosing is the same as Dantrium.
• Differences between the medications:
• Dantrium 20mg vial mixed with 60ml Sterile Water
• Difficult to mix. Time from beginning of reconstitution to administration is approximately 28 minutes.
• Multiple vials needed to achieve recommended initial dose.
• Ryanodex 250mg vial mixed with 5ml of Sterile Water
• Easier to mix
• Faster administration to patient. Time = life for MH.
• With this new product, most patients will only need 1 vial.

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CONVERSION TO RYANODEX

• Total amount of Dantrolene in the cart will actually increase slightly:
• Dantrolene 20mg per vial x 36 = 720mg
• Ryanodex 250mg x 3 = 750mg
• Initial dose is the SAME for both products = 2.5 mg /kg
• Reference Materials / Dosing Ranges in the MH Cart are the SAME. Only updated with direction for mixing and how to determine total dose.
• Volume to administer:

TOTAL DOSE divided by 50= mL

• If continuous infusion of Dantrolene is required, contact pharmacy and order an IVPB. Pharmacy will mix using the 20mg product vials. RYANODEX CAN NOT BE FURTHER DILUTED.

MH DOCUMENTATION FORM

• Documentation form created to mirror layout of Code Blue Record.
• Easier documentation of an event.
• MH Hotline phone number provided.
• If patient arrests during MH, Code Blue Form would be immediately implemented.
• Debrief tool for post event review and evaluation.

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MH DOCUMENTATION FORM