1 of 24

2 of 24

BUSINESS DIALOGUE

KAZAKHSTAN

3 of 24

ECOSYSTEM SHAPING

ONE ROCHE

CULTURE TRANSFORMATION

BUSINESS PLAN

4 of 24

BUSINESS ENVIRONMENT CHANGES

HEALTHCARE SYSTEM SHAPING (HIP)

PHC STRATEGY

Ecosystem shaping

5 of 24

Country overview

Almaty

Shymkent

Nur-Sultan

CITIES

Capital city: Nur-Sultan

Large cities: Almaty, Shymkent

POPULATION: 18.7 mln.

Asians – 77.8%

Urban population – 59%

AREA: 2,724,900 km²

9th largest country in the world

GDP (nominal) – $180 billion

per capita - $11 518

Economy will shrink by 3% in 2020

Healthcare spending - 1.8% GDP

Economically significant resources are coal, uranium, copper, iron, lead, zinc, chromite, gold, manganese

RESOURCE BASED ECONOMY

Oil

(estimated to have around 30 billion barrels),

Gas

(reserves amount �to 3.3–3.7 trillion m3)

Kazakhstan

Kyrgyzstan

China

Russia

Uzbekistan

6 of 24

Impact of covid-19 to Kazakhstan

Total cases

106 661

Recovered

100 409

Deaths

1 656

7 of 24

Impact of covid-19 to Kazakhstan

  • Dedicated funds to fight COVID-19 – $ 451,5 mln
  • The volume of anti-crisis measures �amounted to over $ 9,3 bln.
  • 2 lock downs imposed in March and June
  • Health Minister swapped �amid second lock down
  • Supply chain destruction led to medication deficit
  • Fast track registration of drugs was introduced
  • New drugs listing suspended until further notice
  • 42% of Roche Kazakhstan employees had symptoms of COVID-19

8 of 24

Healthcare system duality

State as REGULATOR

State as �OPERATOR

  • 62% government funding
  • by tax collection
  • 70%/30% state �vs. regional budget

  • 38% social insunce (CSMI) �US$ 660M (2019) �collected in FMSI
  • FMSI is a single operator
  • for health related repayments
  • Medicines price ceiling (200+)
  • Medical equipment price ceiling scheduled from 2021
  • Strong localization agenda�(~50% by 2025)
  • Reimbursement list extended �(+133 new products) vs 2019
  • 58% budget increased vs 2019
  • Centralized
  • public drugs procurement
  • Single State operator�Inpatient list�Outpatient list (ALO)
  • Decentralized

healthcare provision

  • Focus on Primary Care
  • PPP incentives �to increase investment �in healthcare facilities

9 of 24

Kazakhstan Pharma market MAT/2020/08

$17,3

$17,8

$22,8

$28,9

$30,7

$32,4

$40,4

$43,1

Total Market – 1 624 mUSD�Growth +14%

Roche: �Rate #11(+7)�Growth +4%�MS 2,13%

Hospital Market – 619 mUSD�Growth +16%

Roche:�Rate #7(-) �Growth +32%�MS 4,68%

$44,4

$47,6

10 of 24

Healthcare impact plan (HIP) �3 main objectives 2021 & beyond

Collaboration

Value of HTA

ECOSYSTEM

Innovations

11 of 24

Healthcare impact plan (HIP) �3 main objectives 2021 & beyond

Collaboration

Value of HTA

Innovations

ECOSYSTEM

Build platform for ecosystem members

HCPs as decision makers

Support PAG’s

Change the "mindset" of the HC system

Health Economic Academy

Rare disease

PHC

Localization

Bx Strategy

12 of 24

KZ PHC Sunrise: focus areas for 20202025

MGTOs �in clinical practice �& reimbursement

RWD/ RWE

use and recognition

CGP/NGS reimbursement

VBHC �establishment

13 of 24

ECOSYSTEM SHAPING

ONE ROCHE

CULTURE TRANSFORMATION

BUSINESS PLAN

14 of 24

TRANSFORMATION JOURNEY

PEOPLE & CULTURE

COLLABORATION, DIGITAL STRATEGY

Culture transformation

15 of 24

16 of 24

Transformation Journey�

In team we trust�

  • LT commitments (5 frequencies)
  • New KZ vision
  • Weekly LT+TT meetings
  • Feedback and VACC culture
  • KZ values and principles

Digital Collaboration �and Networking

  • New ways of communication (Covid-19)
  • Virtual Coffee Talks
  • Employee Engagement (Go Innovation Project)

Start and Experiment

  • Agility training
  • LT transformation (Serbia, Dalaman)
  • Experience exchange
  • Erickson Diagnostics

Next focus

  • Next level of cultural transformation
  • Building shared TRUST
  • People engagement
  • New operating model
  • New Agile office

Vision of Roche KZ

Transforming ourselves, we create �better solutions for patients

2019

Q1 2020

Q2 2020

Q3-Q4 2020

17 of 24

Current operating model

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Medical

Market

Access

PHC/FMI

DIA

GR & PR

Marketing

& sales

Support:

HR, IT, Fin,

Legal

Field

Force

Oncology

Squad

Product manager

Medical manager

PHC/FMI

Market access

6 KAM

HIP

Squad

Market access

DIA

GR&PR

Product manager

MA

PHC/FMI

Digital

Squad

KAM

PHC/FMI

Project manager

Market access

Specialty care

Squad

Product manager

Medical manager

Market access

6 KAM

People

Squad

DIA

Pharma

HR

Transformation lead

Go-Innovation

Squad

2 PHC/FMI

Project manager

2 Assistant

Product manager

3 KAM

2 Market access

Transformation

Squad

2 KAM

IT

Medical manager

Chief acc/ Transformation lead

GR&PR

GM Assistant

HR

Logistics manager

10

8

5

9

7

11

9

18 of 24

Innovation initiative

Total projects – 17

Digitalization – 8

Transformation – 2

Healthcare impact – 6

Office administration – 1

Total participants – 26 employees (60%)

Grand prix – inspiration tour to worldwide innovation event

GO

Innovation

19 of 24

Compliance conformity milestones

COMPLIANCE �CULTURE

Action Plan

Gaps in documentation �and in understanding

Compliance �Mindset

20 of 24

Inspiration through Collaboration

CCE:

  • Schools in CCE on hemophilia
  • ABBC workshop on Hemlibra
  • Launch for Tecentriq with Ukrainian affiliate
  • GR panel
  • CCE Joint Molecular Tumor Boards

GLOBAL:

  • Transformation training (Giovanni, Suhail, Yasna)
  • HIP expert community
  • Cross-country collaboration on PHC (TR, IL, RU, UZ, TM, IN, PK)
  • Regional CoPs for PHC (CCE, CEETRIS, PI)

CEETRIS:

  • CEETRIS Patient Initiative
  • RIME & webinars with Russian affiliate
  • R&E (Reach and Engage)
  • ReCONNECT

21 of 24

Rocket of Digital transformation

Customer

digital

dngagement

Move to next

intermediate level

Customer �Digital Interaction

RWD development

22 of 24

Roche Kazakhstan Galaxy

Roche

Self Detailing

project

AskMe project

Hemophilia.kz

Neocontrol

HCP

Telegram channel

Oneclick

project

HCP portal

Marketing

& medical

activity tool

(MMA tool)

Project One

Telemedicine

Roche

23 of 24

Discussion

24 of 24

Doing now what patients need next