1 of 9

CARDIOVASCULAR DISEASE RISK ASSOCIATED WITH POLYCYSTIC OVARIAN SYNDROME: �AN ALL OF US STUDY.

ANTONETA KARAJ

2 of 9

Introduction and Significance

PCOS is one of the most understudied disorders among reproductive-aged women, affecting nearly ~6-20% of people worldwide. 1

Cardiovascular disease is still the leading cause of mortality in the U.S. 2

Women without PCOS tend to have fewer cardiac events (compared to those with PCOS).3

CVD risk among women, and comorbidity of another illness, remains an understudied field of research

The All of Us Research Program 4

3 of 9

Research Question

  • Is there an association between PCOS and CVD risk among participants in the All of Us Study?
    • Compared to White participants, will participants in Black and Hispanic racial categories will have different outcomes in cardiovascular health?

4 of 9

Methods

Data Source: �- All of Us Research Program, National Institutes of Health

Measures: CVD Risk, PCOS, Age, Gender, Race, Education, Heart Condition History, Sleep Disorder History

Statistical Analysis: Negative binomial regression models, interpret incident rate ratio (IRR) 5, one final interaction model.

5 of 9

Results

In an unadjusted model, participants with PCOS had an IRR of 0.70 for CVD health (p<0.001)

Participants without PCOS had an IRR of 2.39 for CVD health (p<0.001).

After controlling for covariates, the IRR of CVD health for participants with PCOS was 0.90 (p<0.001).

6 of 9

Results

  • In reference to the White race category, Black and Hispanic groups with PCOS presented IRRs of:
  • 0.91 (95%CI [0.73, 1.15])
  • 0.88 (95%CI [0.75, 1.02])

7 of 9

Conclusion

Participants with PCOS had a 30% less likelihood of having better cardiovascular health and although insignificant, Black participants with PCOS were still observed as having a 10% less likelihood of good cardiovascular health.

Limitations: Population diversity, sample size, interpretation of Life Simple 7 Score, negative binomial model interpretation, All of Us Sampling and data collection methods

Strengths: All of Us large cohort size, inclusion of gender minorities, opportunities for future research

Implications for future research: potential for further understanding of CVD risk among gender and racial minorities.

8 of 9

Acknowledgement

Special thanks to:

​

Dr. Stephanie H. Cook, DrPH

Director of Attachment and Health Disparities Lab, New York University

​

Jennifer Trinier,

Thesis Instructor

​

All of Us Research Program, National Institutes of Health

9 of 9

References

  1. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. Jul 2016;106(1):6-15. doi:10.1016/j.fertnstert.2016.05.003
  2. Virani SS, Alonso A, Aparicio HJ, et al. Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association. Circulation. Feb 23 2021;143(8):e254-e743. doi:10.1161/CIR.0000000000000950
  3. Glintborg D, Rubin KH, Nybo M, Abrahamsen B, Andersen M. Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome. Cardiovasc Diabetol. Mar 8 2018;17(1):37. doi:10.1186/s12933-018-0680-5
  4. NIH. About | All of Us Research Program | NIH. National Institutes of Health. Updated 06/16/2021. https://allofus.nih.gov/about
  5. Kenne Pagui EC, Salvan A, Sartori N. Improved estimation in negative binomial regression. Stat Med. Jun 15 2022;41(13):2403-2416. doi:10.1002/sim.9361

​

​