Decoding the Role of Pigmentation in Fundus Image Analyses using AI 👁️🤖
Dennis Bontempi
Vasculature
Optic Disk
AI 🤖
Segmentation of arteries and veins
Segmentation of arteries and veins
Bifurcations
Tortuosity
Extraction of different vascular features
Genome-wide Association Studies
Disease Association & Mortality/Disease Prediction
Pigmentation
… Depends on age,
ethnicity, diseases…
(maybe even sex)
Pigmentation
… But it’s never �considered in studies!
Machine Learning Derived Retinal Pigment Score
Rajesh, A.E., Olvera-Barrios, A., Warwick, A.N. et al.
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology (Nature Communications, 2025)
Machine Learning Derived Retinal Pigment Score
Rajesh, A.E., Olvera-Barrios, A., Warwick, A.N. et al.
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology (Nature Communications, 2025)
AI & ML 🤖
Retinal Pigment Score
Machine Learning Derived Retinal Pigment Score
Rajesh, A.E., Olvera-Barrios, A., Warwick, A.N. et al.
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology (Nature Communications, 2025)
What is the Retinal Pigment Score ACTUALLY Associated with
What is the Retinal Pigment Score ACTUALLY Associated with
Retinal Pigment score extraction pipeline
Retinal Pigment Score
What is the Retinal Pigment Score ACTUALLY Associated with
Retinal Pigment score extraction pipeline
Retinal Pigment Score
Demographics & Diseases
What is the Retinal Pigment Score ACTUALLY Associated with
Retinal Pigment score extraction pipeline
Retinal Pigment Score
Demographics & Diseases
Test Associations
(potentially for different groups)
What is the Retinal Pigment Score ACTUALLY Associated with
Retinal Pigment score extraction pipeline
Retinal Pigment Score
Demographics & Diseases
Test Associations
(potentially for different groups)