Adenoma (Duodenum)

Duodenal tumors are rare lesions, but of these, adenomatous polyps are the most common type of duodenal tumor found. They are often found at the gastroduodenal junction. The risk of malignancy for these lesions parallels that of colonic adenomas, with villous histology being more concerning than tubular histology. Patients who develop duodenal adenomas in the background of FAP carry a higher risk of developing malignancy.

• Hyperchromatic glands with architectural distortion
• Pseudostratified epithelium with high N:C ratio
• Areas of dysplasia lack goblet cell differentiation (red arrow)

​

​

BRUNNER’S GLANDS

Adenoma seen on the right. Note that this section is identifiable as duodenum because of the Brunner’s glands seen at left.

​

​