IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars
Feb 17, 2022
Welcome - The meeting will start at 3PM ET
NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND
Agenda
People
Co-Lead: Reinhard Laubenbacher, PhD
Department of Medicine
Laboratory for Systems Medicine
University of Florida
reinhard.laubenbacher@medicine.ufl.edu
Co-Lead: James A. Glazier, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Web Administration, Slack: James P. Sluka, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Activities Coordination: Lorenzo Veschini, PhD
King’s College London
Slack Channel
https://Msm-working-group.slack.com
Our IMAG/MSM Wiki page
https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!
Or, use the Tiny URL: https://tinyurl.com/hkr97vfe
IMAG’s LinkedIn
YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd
Please follow the�group on Twitter!
If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.
Announcements
�Any short (~1 minute) items such as;
The Crick is currently recruiting specifically for early-career group leaders working in “Computational and theoretical biology”. Building a strong base in this area, which has been weakened by recent GL departures, is an important aspect of the Crick’s interdisciplinary research agenda.
The positions come with a very attractive core funded research package.
The call is now open with a deadline �for applications of March 10th.
www.crick.ac.uk/group-leader-recruitment
Schedule for Upcoming Meetings and mini-Seminars
Feb 24:
Request for future speakers (Feb 17, 24, …)
Rules of the Meeting
Please mute your microphone and hold questions until after the presentations
Mini-Seminar�Coupled PK model of an antiviral and agent-based model reveal the importance of inter-cellular metabolism heterogeneity on treatment outcomes
Juliano Ferrari Gianlupi�Indiana University
We extend our established agent-based multiscale computational model of infection of lung tissue by SARS-CoV-2 to include pharmacokinetic and pharmacodynamic models of remdesivir. We model remdesivir treatment for COVID-19; however, our methods are general to other viral infections and antiviral therapies. We investigate the effects of drug potency, drug dosing frequency, treatment initiation delay, antiviral half-life, and variability in cellular uptake and metabolism of remdesivir and its active metabolite, GS--443902, on treatment outcomes in a simulated patch of infected epithelial tissue. Non-spatial deterministic population models which treat all cells of a given class as identical can clarify how treatment dosage and timing influence infection dynamics, and treatment efficacy. However, they do not reveal how cell-to-cell variability affects treatment outcomes. Our simulations suggest that for a given treatment regime, depending on many factors including cell-to-cell variation in drug uptake and permeability increases the likelihood of uncontrolled infection in the tissue patch because the cells with the lowest internal levels of active metabolite act as super-spreaders within the tissue. The model predicts substantial variability in infection outcomes between similar tissue patches for different treatment options. In the models with cellular metabolism variability, antiviral doses have to be increased significantly (more than 50% depending on simulation parameters) to achieve the same treatment results as with the homogeneous cellular metabolism. After the presentations we will have breakout rooms for each of the speakers where you may discuss technical questions.
Requests for Input/Suggestions
We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present
Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite
Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively
There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions
Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues
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