IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars
April 14, 2022
Welcome - The meeting will start at 3PM ET
NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE UNABLE TO ATTEND
Agenda
People
Co-Lead: Reinhard Laubenbacher, PhD
Department of Medicine
Laboratory for Systems Medicine
University of Florida
reinhard.laubenbacher@medicine.ufl.edu
Co-Lead: James A. Glazier, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Web Administration, Slack: James P. Sluka, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Activities Coordination: Lorenzo Veschini, PhD
King’s College London
Slack Channel
https://Msm-working-group.slack.com
Our IMAG/MSM Wiki page
https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!
Or, use the Tiny URL: https://tinyurl.com/hkr97vfe
IMAG’s LinkedIn
YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd
Please follow the�group on Twitter!
If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.
Announcements
�
Any short (~1 minute) items such as;
Schedule for Upcoming Meetings and mini-Seminars
April 21:
April 28:
May 5:
Request for future speakers (May 5, …)
Mini-Seminar� Ushering Therapeutic Sound Waves into the Era of �Precision Cancer Immuno-Oncology
Natasha D Sheybani�University of Virginia
Despite the promise of cancer immunotherapy, a significant fraction of cancer patients are yet unable to realize its unparalleled benefits. Focused ultrasound (FUS) is a versatile, emerging technology for the non-invasive, non-ionizing, and precisely targeted deposition of acoustic energy into tumor tissues. Recent years have unveiled the capacity of FUS to potentiate cancer immunotherapy through immuno-modulation and targeted drug delivery. In this talk, I will discuss our translational efforts to systematically interrogate the impact of thermal and mechanical FUS regimes on immunological sequelae and extracellular vesicles in solid tumor settings (e.g. metastatic breast cancer, glioblastoma). I will also introduce our goal of ushering FUS into the era of precision immuno-oncology using advanced imaging, liquid biopsy, and artificial intelligence.
Mini-Seminar�Modeling species interaction in the gut microbiota �using data from hospitalized patients
Joao Xavier�Memorial Sloan Kettering Cancer Center
The gut microbiota is a microbial ecosystem amenable to mathematical modeling. We will discuss our work at the Memorial Sloan-Kettering Cancer Center where we use data from patients to quantify the ecological interactions. The data consists of timeseries of microbial populations and clinical metadata such as the antibiotics given to patients and their number of white blood cells on each day. The model reveals which microbes are most important for patient immunity. Studying ecology directly from patient data can help drive new treatments to modulate immunity by engineering the gut microbiome.
Requests for Input/Suggestions
We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present
Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite
Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively
There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions
Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Lorenzo Veschini with your ideas on all of these issues
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