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ATP Synthesis

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Cell respiration

Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to synthesis biochemical energy (ATP) from nutrients (glucose) and then release waste products.

Glucose

Glycolysis

TCA cycle

Electron Transport chain

Pyruvate

e-

e-

e-

e-

ATP

Schematic representation of synthesis of ATP in cell

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Electron Transport Chain

Transfer of electrons from NADH and FADH2 to O2 via multiple carriers

Outer

Inner

Matrix

NADH

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ATP synthase

Flow of reactions for ATP synthesis in cell

Glucose

2 Pyruvate

2NADH

Glycolysis

2ATP

Cytoplasm

Mitochondria

Transporter

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Shuttle for “cytosolic NADH transfer to mitochondria”

Cytosol

Mitochondria

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Four complexes of Electron Transport Chain

Electron carriers

1.FMN : Flavin MonoNucleotide

2.Fe-S : Iron Sulfur protein

3. Q : Co enzyme Q

4. FAD : Flavin Adenine dinulceotide

5. Cyt : Cytochrome b, C1

6. Cu : Copper

7. Heme : Heme protein a, a3

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Inhibitors of Electron Transport Chain

N,N-Dicyclohexylcarbodiimide (DCCD); Carbonyl Cyanide 4 (Trifluoromethoxy)phenylhydrazone (FCCP)

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