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HMP Shunt

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Breakdown of amylose into maltose and glucose units

Amylases

α-amylase

β-amylase

γ-amylase

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Glycolysis

HMP

Glucose

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Glucose trapping in cell - Hexokinase

Glucose

Glucose

Glucose 6 Phosphate

Hexokinase

Glucose

Transporter

Glucose

Glucose

Glucose

Glucose

Transporter

No beneficial

effects

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Phosphogluconate Pathway

Hexose Monophosphate Pathway (HMP)

Pentose Cycle

Warburg-Dickens-Lipman Pathway

Pentose phosphate pathways

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HMP shunt (2 phases)

Oxidative (Irreversible)

Non oxidative

Reversible

HMP Shunt

Glucose 6 Phosphate

Ribulose 5 phosphate

Dehydrogenation

Decarboxylation

NADPH

CO2

Cholesterol biosynthesis

Ribulose 5 phosphate

Glucose 6 Phosphate

Transketolase

Transaldolase

Ribose 5 Phosphate

DNA, RNA

synthesis

Isomerase

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Rate limiting

enzyme

Decarboxylase Rxn

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Significance

Ribulose 5 phosphate

  1. DNA, RNA, ATP,
  2. NAD+, FAD, & CoA

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Significance

Fatty acid biosynthesis

Cholesterol biosynthesis

Glutathione synthesis

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Significance

Detoxification

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Lens transparency

NADPH preserves

transparency of lens

Significance

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