Dialysis Access
David S Bjerken MD FACS
DaVita Physician Support Network
Medical Director, McLeod Loris Dialysis Access Center
Myrtle Beach, SC
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Disclosures
Brief History of Dialysis, Transplant and Dialysis Access���
ESRD Prevalence Trends (United States)
Data based on United States Renal Data System (USRDS) annual reports.
Year | Total Prevalent ESRD Cases (Approximate) | Primary Drivers/Notes |
1990 | ~180,000 | Early growth of dialysis infrastructure. |
2000 | ~370,000 | Expansion of Medicare coverage for ESRD. |
2010 | ~590,000 | Increased obesity and diabetes rates. |
2015 | ~700,000 | Improvements in cardiovascular care (patients living longer). |
2020 | ~800,000+ 71% dialysis, 29% transplant | Significant growth in home dialysis and transplant waitlists. |
Aging Out
in the
US
1. KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update Lok, Charmaine E. et al. American Journal of Kidney Diseases, Volume 75, Issue 4, S1 - S164�
National Kidney Foundation KDOQI CPG for Vascular Access 2019
We have a clinical imperative to ensure “the right access for the right patient at the right time for the right reasons,”1
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Shifting Mantra���Shifting ‘PLAN’
“Fistula First” Initiative 2004
“Fistula First, Catheter Last”
“The Right Access in the Right Patient at the Right Time for the Right Reasons” 2019
ESKD “Life PLAN”
PLAN = Patient LifePlan Access Needs
Contingency and Succession Plans for Access
Forms of dialysis and access
Transplant
PD
Fistula
Graft
Catheter
METRICS!�Our Nephrologists are held to many Metrics…
Learn the challenges of your nephrologists to better align your service to their needs…
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What’s the story with PD?
These are challenges:
Reasons for optimism:
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What are the advantages of Peritoneal Dialysis (PD)?
Preserves residual renal function 1
Early survivor advantage 2
Decreased hospitalization rates 3
Prevents need for central venous catheters
Gets patients Medicare sooner4
Higher quality of life measures 5
Lower overall cost of care
Better outcomes at transplantation
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Methods
Matched
Retrospective
1:1 Cohort Study
No prior
Kidney Smart Education
Home
Dialysis
Permanent
Vascular Access
Received
Prior Kidney Smart Education
38.5%
1. Reference: Utilization of Home Dialysis and Permanent Vascular Access at Dialysis Initiation Following a Structured CKD Education Program; Katherine Mckeon, Scott Sibbel, Steven M. Brunelli, Erin Matheson, Nick Lefeber, Meghan Epps, and Francesca Tentori
Utilization of Home Dialysis and Permanent Vascular Access at Dialysis Initiation Following Kidney Smart CKD Education Program
One-time
In-person/Virtual Kidney Smart class
Cohort
Results
Primary Outcomes
Secondary Outcomes
57.9%
1.00
Hospitalization
Admissions/
patient year
1.38
33.8%
12.6%
Mortality
Higher mortality in first year
Lower mortality
p < 0.001
p < 0.001
p < 0.001
p < 0.001
Conclusion: Attending a Kidney Smart CKD Education class prior to starting dialysis was associated with positive clinical outcomes, including lower hospitalization and mortality rates.
2,398 Adults with CKD
Embedded Catheters Can Reduce the Gap Between Those that Chose PD and Those that Start PD �
~48%
Chose PD
and started dialysis
Chose
PD and started PD
The Gap
Unplanned start on HD with CVC
Percent
Pyart et al. Perit Dial Int 2018; 38:328-333
Liebman et al. Am J Kidney Dis 2012; 59: 550–557
Heaf et al. Clin Kidney J 2021; 14:2064-2074
Heaf et al. Clin Kidney J 2021; 14:933-942
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Majority of Patients “Crash” in to Dialysis
And CVC becomes the default access option1
60%
of patients who progress to ESRD do not have a distinct plan at the time of dialysis therapy initiation3
80%
of patients were using a CVC at HD initiation2
Sources: 1) Machowska A, Alscher MD, Vanga SR, Koch M, Aarup M, Ruthorford P. Offering Patients Therapy Options in Unplanned Start: Development and Implementation of an Education Program for Unplanned-Start Patients. Advances in Peritoneal Dialysis;31:69-73. | 2) US Renal Data System, 2022 Annual Data Report | 3) Ghaffari A. Urgent-start peritoneal dialysis: a quality improvement report. Am J Kidney Dis. 2012;59: 400–408
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Change in Dialysis Access Type Over 18 Months Following Initiation of HD with a CVC�
USRDS 2020 ADR, Figure 3.8b
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Understanding Basics of PDC Placements
3 Placement Techniques
3 Types of Proceduralists
3 Scenarios for Patient Timelines
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Peritoneal Dialysis Catheter Placement Timeline�
Classification of Dialysis Start | Anticipated Dialysis Start Time |
Urgent Start | 24 hours to 14 days |
Routine Start | 14 days to 30 days |
Embedded Catheter | 2 to 12 months |
How soon will the PD catheter be needed?
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Examples of Patient Path to PD
HD Conversion
24 hours to 14 days
14 days to 30 days
> 90 days
30 days to 24 months or more
Embedded Catheter
Urgent Start
Planned but Crashed
No Prior Nephrologist Care
AKI staying on PD
Routine Start
Planned
Controlled
Start
Crash 🡪 HD 🡪 PD
Standard 🡪 HD 🡪 PD
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Urgent Start PD – Use in less than 2 weeks from placement procedure��
Rectus Muscle and Sheath
Rectus Tunnel
Deep Cuff in Muscle
Purse String
Paramedian Incision
Surgical
Clinical
Strategies to Prevent Early Pericatheter Leaks
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Embedded Peritoneal Dialysis Catheters�Reasons to Use this Technique in General
�
DaVita does not prescribe treatment type, frequency, or prescriptions, and defers to the nephrologist to prescribe on a patient by patient basis.
References: 1. Crabtree JH, Burchette RJ, Siddiqi RA. Embedded Catheters: Minimizing Excessive Embedment Time and Futile Placement while Maintaining Procedure Benefits. Perit Dial Int. 2015 Sep-Oct;35(5):545-51. doi: 10.3747/pdi.2013.00301. Epub 2014 Oct 7. PMID: 25292403; PMCID: PMC4597987.. 2. McCormick BB, Brown PA, Knoll G, Yelle JD, Page D, Biyani M, Lavoie S. Use of the embedded peritoneal dialysis catheter: experience and results from a North American Center. Kidney Int Suppl. 2006 Nov;(103):S38-43. doi: 10.1038/sj.ki.5001914. PMID: 17080110.
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How to get great results and less catheter malfunction!�Best Demonstrated Practices
https://journals.sagepub.com/doi/pdf/10.3747/pdi.2018.00232
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Challenges for Optimal Choice of Peritoneal Dialysis Catheters�
Odd Skin Folds
Obesity
Massive Weight Loss
Drooping Pannus
Adult Diaper
Intestinal Stoma
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Must Have Flexibility in Exit-Site Placement�
A basic catheter inventory is mandatory to produce:
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Standard Abdominal Catheters
25
Coiled-tip, 2-cuff, Straight Intercuff
Coiled-tip, 2-cuff, Intercuff Preformed Bend
Straight-tip, 2-cuff, Straight Intercuff
Straight-tip, 2-cuff, Intercuff Preformed Bend
USMP/MG2/16-0005a(2) 09/17
Extended Catheter System
Presternal or Upper Abdominal Catheter Exit Site
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Titanium Connector
1 or 2-Cuff Extension Tube with Preformed Intercuff Bend
1-Cuff Coiled-Tip Catheter
Getting it Right! Use a Stencil to mark and choose Exit Site and Catheter
4 results of Stencil-based marking
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Conventional
Embedded
�Proactive and Adjunctive Procedures With Laparoscopic Implantation
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Outpatient Peritoneal Dialysis for AKI
1. American Nephrology Nurses Association. (n.d.). Acute kidney injury clinical fact sheet. https://www.annanurse.org/download/reference/practice/akiClinicalFactSheet.pdf
2. Rottembourg J. Residual renal function and recovery of renal function in patients treated by CAPD. Kidney Int Suppl. 1993 Feb;40:S106-10.
Acute Kidney Injury (AKI) is the sudden loss of kidney function within hours to days1, requiring renal replacement therapy. Patients may partially or completely regain renal function, but others might never recover and may transition to ESKD.
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Secondary Embedding: Option 2
Crabtree et al. Peritoneal dialysis catheter embedment: surgical considerations, expectations, and complications. Am J Surg 2013; 206:464-71.
This segment is removed.
Step 1 - Expose intercuff segment
Step 2 - Add extension with titanium connector
Step 3 - Tunnel to ultimate exit site
Step 4 – Embed and excise old exit site
Crabtree JH. Secondary embedding of peritoneal dialysis catheters. Perit Dial Int 2008; 28: 203–206.
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Rescue from Catheter Malfunction�(You pretty much have to look = Laparoscopy, and we seldom need to remove or replace a catheter)�
Redundant Omentum�
Omental Wrap
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What to do with this??
Tunnel tract infection = Superficial cuff abscess
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Hemodialysis Access�The Realities - The Challenges
Care is shared between multiple subspecialists GS,VS,IR,IN
Often none of these consider it a priority or a joy, rather an add-on to an otherwise complex practice.
Residency training is lacking.
Best practices are poorly defined.
Everything nephrologists want is urgent.
We are essentially continuously managing against failure.
Hemodialysis Access�The Bright Side(Maybe not sexy but can be attractive!)
The need is growing for access care.
It is a deeper speciality than one might expect, a challenging venture.
There are some good algorithms and standards.
Access care brings forth quite a lot of creativity.
The patients are underserved, appreciative, and offer long-term patient relationships.
There are worthwhile resources, VASA, CIDA.
It may seem altruistic(it is) but this is a very rewarding practice when taken as a whole.
~2x
risk for �hospitalizations
27
more days per year �in the hospital
7
additional hours �of RN time per �pt/per year
~4x
risk of �infection
Why Do We Care So Much About CVCs?
CVC Patients Have, On Average:
~2x
risk of mortality
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Dialysis Basics �for the Non-Nephrologist
What Are the Elements of an Ideal Access?
Tailored to the individual patient’s needs
Meets the “Rule of 6’s”
Allows for prompt removal of a catheter
Matures within 60 days
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Tailoring Access to the Patient
Not every patient needs a fistula
Patients with poor vasculature or short life expectancy may be better served with a graft
Early cannulation grafts may reduce or eliminate catheter days
There are alternatives for patients with “exhausted sites”
Plan ahead for “what’s next”
Logistical concerns may dictate access choice
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Optimal Timeline —�Access referral to Cannulation(and Catheter out!)�
Day 0=Surgical referral
Day 10=Surgical Appointment + Mapping
Day 24=Surgical Access Creation
Day 66=First Cannulation – Mark Centerline
Day 80=Catheter out!
Maintenance 1.8x/year – triggers for evaluation
Post op appointments @3,6 weeks = Maturity
Our nephrologists and dialysis units are held to many metrics!
We need to help with catheter and fistula rates.
Cut to the Chase �Key Moves - Lessons learned over time
Ultrasound is your best friend. Vessel mapping preop, Choose a side R/L. Intraop confirm mapping, plan incision
Supraclavicular block – anesthetic safety and vasodilation.
Avoid side of pacer, AICD.
Avoid steal by RC or PRA anastomosis or axillary. Beware with PAD and go proximally.
Treat steal with PAI Proximalization of the Arterial Inflow 10+cm 4 mm artegraft
Office FU with US “Rule of 6’s” depth, diameter and BA flow, for assessment of maturity.
Early fistulagram if not maturing.
“It’s all about the tunneling” grafts, transposition and.catheters
Algorithm for maintenance and salvage
INFLOW
OUTFLOW
CONDUIT
Modes of �Access Care���“The Right Access for the Right Patient at the Right Time for the Right Reasons”
Create
Maintain
Salvage
Abandon
VESSEL MAPPING�
Create Maintain Salvage Abandon�������Inflow Outflow Conduit
Fistulas
Wrist - RC/Snuffbox
Upper arm - PRA/PUA/Gratz/BC/MC/BB
Transposition(lift, superficialization, elevation)
PSLOT anastomosis
Percutaneous Ellipsys WavelinQ
Always repeat ultrasound in OR after supraclavicular block
Access in Stage 4,5 – Not on Dialysis
“Fistula Only!!”
��������
Rule of 6’s Fistula Maturity
6 weeks
6(5) mm deep
6 mm diameter
600 cc/min flow
6 cm cannulation zone
Create Maintain Salvage Abandon������Its all about the Tunneling
GRAFTS - materials
Bovine Carotid Artery -Artegraft
PTFE –Early Cannulation
Flixene, Acuseal, Vectra, Avflo
HeRO - venous outflow component
“If you think you’re too close to the skin...
you got it right!” John Ross MD Access GURU
Early Cannulation Grafts
1
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Structure: Middle graft layer
Elastomeric membrane middle graft layer
Benefits of middle graft layer design
1 Mohapatra A, Yuo TH, Lowenkamp MN, et al. Cost-effectiveness analysis of immediate access arteriovenous grafts versus standard grafts for hemodialysis. Journal of Vascular Surgery. In press.
2 Wagner JK, Dillavou E, Nag U, et al. Immediate-access grafts provide comparable patency to standard grafts, with fewer reinterventions and catheter-related complications. Journal of Vascular Surgery 2019;69(3):883-889.
3 Post Post hemodialysis needle removal apply 10-15 minute digital pressure to achieve hemostasis
4 Glickman MH, Burgess J, Cull D, Roy-Chaudhury P, Schanzer H. Prospective multicenter study with a 1-year analysis of a new vascular graft used for early cannulation in
patients undergoing hemodialysis. Journal of Vascular Surgery 2015;62(2):434-441. http://www.sciencedirect.com/science/article/pii/S0741521415003651.
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Create Maintain Salvage Abandon������Inflow Outflow Conduit
GRAFTS - configuration
FA loop BA-BV
FA straight RA-CV/MC
UA loop – proximal or distal
UA curved
HeRO – BA-VOC
Chest loop/necklace
Thigh loop
Catheters
Right Atrium intended tip location
R over L- less vein contact
Tip type – split, palindrome, step
Retrograde/antegrade tunnel
First use phenomenon
Catheter exchange – fibrin sheath
Inside Out – Surfacer HeRO VOC
Create Maintain Salvage Abandon������Inflow Outflow Conduit
MAINTENANCE - average 1.8/year
Angioplasty
DCB InPact AV, Lutonix, Paclitaxel
Covered Stents- Covera, Viabahn, Fluency Plus Wrapsody
Revision for ulceration, aneurysm, steal
Fistulagram and angioplasty
Fistulagram and angioplasty
Left Forearm Radial Cephalic Fistula
History
Physical exam
Create Maintain Salvage Abandon������Inflow Outflow Conduit
SALVAGE
Declot
TPA, Angiojet, Cleaner
Stents
Revision
ABANDON
Challenges and complications
Steal - DASS Dialysis Access Steal Syndrome
Neuropathy peripheral, CTS, IMN
Aneurysms
Pseudoaneurysms
Infection
PD and tunnel catheter malfunction
DASS �Dialysis Access Steal Syndrome
Arterial study – PAD
PAI – Proximalization of the Arterial Inflow
DRIL – Distal Revascularization Interval Ligation
RUDI – Revision Using Distal Inflow
DRAL – Distal Radial Artery Ligation
Banding – Central, Precision
Ligation
Proximal Radial Artery�Anastomosis�PRA
High Flow AV Access �Long-term Cardiac Concerns - Pulm HTN
Banding – Central, Precision
RUDI – Revision Using Distal Inflow
PAI – Proximalization of the Arterial Inflow
Ligation
Dialysis Access Center - Why?
CENTRALIZED CARE
COMPREHENSIVE CARE
QUALITY & SAFETY
SERVICE
davidbjerken@gmail.com 843-443-5784
Valuable Resources
Information per Dr. Bjerken’s experience and expertise
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Training and Education for Dialysis Access Care(PD, HD)
Dialysis Access is truly a specialty of its own
Interventional Nephrology(IN) is a fellowship which is well established
Percutaneous PD and AVF by IR and IN are happening
There are organizations(VASA, ISPD, ASDIN) and meetings(VASA, CIDA, ASDIN) journals(JVA, PDI) and corporate support(DaVita, Vantive, Merit, Mozarc)
Training and Education in Dialysis Access Care - PD and HD
PAI