Neurophysiology Plus
Brain Ecology Lab
3rd Journal Club Meeting, 22nd of May 2019
-Cortical silent period changes as measurement of intracortical inhibitory dynamics
-Acute and chronic ethanol intake CSP measured with TMS
-Investigating CSP and CuSP after acute alcohol intake (last slide)
Ovidiu C. Banea
Papers to discuss:
Vavilov Ice Cap _Fake vs Science
Vavilov Ice Cap _Fake vs Science
Vavilov Ice Cap _Fake vs Science
CSP / CuSP
Intervention 700ml wine 12% (here)
Ziemann et al 1995
Ziemann et al 1995
Conte et al 2008
rTMS delivered in trains of 10 stimuli at 5 Hz frequency with an intensity of 120% RMT.
subjects were studied at rest and during a sustained voluntary contraction of the FDI muscle (30% of the maximum EMG activity) on the same day.
In the active condition, subjects were instructed to perform a constant level of muscle contraction for about 4 s before and after the trains and to rest between trials. Under both experimental conditions (rest and active contraction), muscle activity was monitored through an audio–visual feedback
In each condition 10 trains were delivered with an inter-train interval of about 1 min.
Conte et al 2008
Conte et al 2008
Conte et al 2008
RESULTS In healthy subjects before and after acute ethanol intake, 5 Hz-rTMS produced a significant increase in the MEP size and CSP duration during rTMS.
The first CSP in the train was significantly longer after than before ethanol intake. In patients 5 Hz-rTMS failed to produce the normal MEP facilitation but left the CSP increase unchanged.
Conclusions: Acute and chronic ethanol intake alters cortical excitability and short-term plasticity of the primary motor cortex as tested by the MEP size facilitation and CSP lengthening after 5 Hz-rTMS.
Significance: This finding suggests that rTMS is a valid tool for investigating the effects of ethanol on cortical plasticity in humans.
Our experiment (here)