COVID-19 aka “coronavirus”:
These things make it WORSE
and make YOU more SUSCEPTIBLE
Getting the coronaviruses straight...
SARS (Severe Acute Respiratory Syndrome CoronaVirus), or SARS-CoV: The “first” coronavirus from 2003. This is NOT our focus, but will come up.
Now, to cover all the terms for this NEW coronavirus:
Many names for the same things makes it hard to research as effectively, right?
What will we be covering today?
Research showing that receiving the influenza vaccination (aka “the flu shot”) increases one’s susceptibility to getting a coronavirus infection.
Research showing how FIRST EXPOSURE to certain viruses (through infection or vaccines) does NOT make one immune, but actually makes the SECOND INFECTION MUCH WORSE.
Research showing that certain viruses and vaccines are cross-reactive with each other (have similar-enough proteins to cause reactions), which plays into the first two items above in critical ways.
Getting “flu shot” makes one more susceptible
Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017-2018 influenza season.
“Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. �[...]�Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus…”
What is sensitization?
It is “the state in which an enhanced IMMUNE RESPONSE is provoked by a second exposure to an ANTIGEN.”
Most people are familiar with this process from the allergy world.
First exposure sensitizes (mild or moderate reaction), second exposure and later exposures result in potentially deadly anaphylactic reactions.
This is important for the next several slides.
Sensitization pattern with Dengue Fever infection & vaccine
Dengue Vaccine Controversy In The Philippines
“DOUCLEFF: Here's the problem. For children who have already been exposed to dengue, the vaccine is safe and works pretty well. But there is an unusual thing about the dengue virus. The second infection can be a lot worse than the first. So for kids who have never had the disease, the vaccine acts as the first exposure. So if they are exposed to dengue later on, they're at a higher chance of having this severe reaction.”
KEY TAKEAWAYS:
Sensitization pattern with RSV infection & vaccine
Viral and Host Factors in Human Respiratory Syncytial Virus Pathogenesis
“It seems reasonable to suspect that neonatal infection of certain individuals may, depending on timing and genetic background, mediate long-term pathogenic changes to the developing lung and host response. [...] It is possible that the immunological imprint of this first infection is related to the lifelong susceptibility to RSV reinfection.”
RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets
“Children previously immunized with a formalin-inactivated RSV (FI-RSV) vaccine exhibited enhanced respiratory disease following natural RSV infection.”
SARS-CoV vaccines follow the same patterns
A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus
“These vaccines can induce potent neutralizing and protective responses in immunized animals but may induce antibodies that enhance infection by early human SARS-CoV and animal SARS-CoV–like viruses (6).”
More on the SARS-CoV vaccine-enhanced disease
“VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic infiltrates within the lungs of SARS-CoV– challenged mice.”
Prior Immunization with Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus (SARS-CoV) Nucleocapsid Protein Causes Severe Pneumonia in Mice Infected with SARS-CoV
What is Cross-Reactivity?
“Cross-reactivity, in a general sense, is the reactivity of an observed agent which initiates reactions outside the main reaction expected. In immunology, the cross-reactivity has a more narrow meaning of the reaction between an antibody and an antigen that differs from the immunogen.”
Put more simply, cross-reactivity occurs when the proteins in one substance are similar to the proteins found in another substance, with the body reacting to both.
Why is this important?
What if viruses or vaccines were cross-reactive with each other? They are.
Cross-Reactivity in animals and pandemic viruses
Swine Influenza A Vaccines, Pandemic (H1N1) 2009 Virus, and Cross-Reactivity
“Since its first emergence in the human population in spring 2009 (1–3) infections with pandemic (H1N1) 2009 virus have been reported in pigs, turkeys, and some carnivore species (4,5).�[...]�Proof of cross-reactivity was also reflected in the infection trial. Pigs infected with avian-like H1N1 responded to avian-like H1N1 as well as to pandemic (H1N1) 2009 virus.”
Multiple cross-reactivities, potentially across multiple species! If that doesn’t concern you, then the next one will...
“By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)—associated coronavirus (SARS-CoV) and 2 HCoVs [human coronaviruses] (229E and OC43) was demonstrated in immunized animals and human serum. �[...]�Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs.”
Can there be cross-reactivity AND sensitization?
Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (δ-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus.
Apparently so!
The question is, do any of the other CoVs have cross-reactivity with COVID-19, and would they act as a FIRST EXPOSURE?
This sets up some very important questions!
SARS-CoV (the “first” one) happened in China in 2003. According to WHO Data, there were 6873 recovered cases in China. Would ALL those people (reported, suspected, or not) who had their FIRST EXPOSURE back then have a STRONGER reaction to COVID-19?
Are the “deadly re-infections” said to be happening from COVID-19 from the medications, a second exposure, or some combination of both?
Mandatory vaccinations in China started October 2019. Was anyone given a SARS-CoV vaccine? If so, did these vaccines (first exposure) set people up for a later, stronger infection?
Could the vaccines CURRENTLY IN DEVELOPMENT for coronavirus set previously uninfected people up for more severe infections later? Remember, the SARS vaccine was ABANDONED!!!
Based on what I know, I’ll DEFINITELY be skipping THAT vaccine, thank you very much!
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