IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars

Feb 3, 2022

Welcome - The meeting will start at 3PM ET

NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND

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Agenda

1. Welcome
2. Links, people, other info
3. Social media links
4. Quick Announcements
5. Upcoming Mini-Seminars and Request for Future Speakers
6. Hana Dobrovolny, Texas Christian University. Modeling viral coinfections of the respiratory tract.
7. Request for Further Business

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People

Co-Lead: Reinhard Laubenbacher, PhD

Department of Medicine

Laboratory for Systems Medicine

University of Florida

reinhard.laubenbacher@medicine.ufl.edu

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Co-Lead: James A. Glazier, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jaglazier@gmail.com

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Web Administration, Slack: James P. Sluka, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jsluka@indiana.edu

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Activities Coordination: Lorenzo Veschini, PhD

King’s College London

lorenzo.veschini@gmail.com

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Slack Channel

https://Msm-working-group.slack.com

Twitter

https://twitter.com/MsmViral

Our IMAG/MSM Wiki page

https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!

Or, use the Tiny URL: https://tinyurl.com/hkr97vfe

IMAG’s LinkedIn

https://www.linkedin.com/groups/12095434?lipi=urn%3Ali%3Apage%3Ad_flagship3_search_srp_all%3B1FVndkN2SD6P0xj2PYfqdQ%3D%3D

YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd

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Please follow the�group on Twitter!

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https://twitter.com/MsmViral

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If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.

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Announcements

�Any short (~1 minute) items such as;

• announcements
• meetings
• funding
• publications
• requests for help
• ???

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Schedule for Upcoming Meetings and mini-Seminars

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Feb 10:

1. Kevin Janes, University of Virginia. TItle: Stress testing complete kinetic models of individualized enteroviral infection
2. William Waites, Uni Strathclyde. TItle: Compositional modelling of adaptive immune response to and disease transmission of SARS-CoV-2

Feb 17:

1. Juliano Gianlupi, Indiana University, Title: Coupled PK model of an antiviral and agent-based model reveal the importance of inter-cellular metabolism heterogeneity on treatment outcomes
2. TBD

Feb 24:

1. Hayriye Gulbudak, University of Louisiana at Lafayette. Title: Coupled systems that have in-host and between-host components for various infectious diseases.
2. TBD

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Request for future speakers (Feb 3, …)

Rules of the Meeting

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Please mute your microphone and hold questions until after the presentations

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Mini-Seminar�Modeling viral coinfections of the respiratory tract

Hana Dobrovolny�Texas Christian University

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Many patients hospitalized with influenza-like illnesses have been found to be infected with more than one virus. Clinical studies have found mixed results when investigating whether coinfections lead to more severe disease, with some studies even suggesting that coinfections are less severe than mono-infections. We use mathematical modeling to investigate the range of possible dynamics during viral coinfections in an effort to better understand clinical outcomes.

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Requests for Input/Suggestions

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We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present

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Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite

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Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively

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There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions

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Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues

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