MAGIC
Final Presentation �
Stella K. Abraham High School, NY
May 29, 2019
Agenda
Chani Rabinow
9th Grade
My Mentor
My Project
Experiment
t
These are the books that I will be using.
Process
In order to perform the testing necessary on human subjects, the experiment had to be approved
by the Institutional review board (IRB)committee.
Results
The Future
My MAGICal Experience
My MAGICal Experience.
Thank You!
Anna Laufer
<Grade 10>
My Mentor
Understanding Vaping
Understanding Vaping
Things I Learned
Things I Learned
Past and Future Work
My MAGICal Experience
Highlights
Lessons Learned
Challenges
My Demo
Thank you!
Ariella Borah
<Grade 10>
My Mentor
My MAGICal Experience
My Project
Resistance News
Resistance Worldwide:
EU-25,000 deaths per year;
INDIA-over 58,000 babies die per year
THAILAND-38,000+ deaths per year
UNITED STATES-23,000 deaths per year
Bacteria
Bacteria are all around us…
Diseases caused by bacterial infections and to treat them antibiotics are given
Antibiotics fight these harmful bacteria, saving millions of lives in the process...
Antibiotics:
Bacteriostatic - bacteria can communicate with each other, so if one dies the other will try to evolve; if something is bacteriostatic there is no stress signal, so then the dosage becomes very important; then the body clears up the bacteria on its own; there are more known antibiotics that are bactericidal; the dosage can be much higher for bacteriostatic because you don’t want to shock your body too much and send off to much stress signals
Bactericidal - they destroy the cell wall, causing the cell to burst and die.
Broad Spectrum - kill more than one type of bacteria, not just a specific type
Targeted - only kill a specific type of bacteria
Penicillin
First Antibiotic
Bactericidal
Broad Spectrum
Bactericidal
Broad Spectrum
Most commonly prescribed
Ampicillin
Bactericidal
Broad Spectrum
Most Commonly Prescribed
Amoxicillin
Broad Spectrum
Bacteriostatic
Azithromycin
Antibiotics Worldwide:
Early Penicillin
Early Penicillin Uses
Bacterial Infections
Experimental Plan
Planned to Test: The effect of different concentrations of bacteriostatic and bactericidal antibiotics on bacterial growth of cultures taken from locations in the community.
Bacteria Resistance Study at Harvard
This is a graph showing the effect of antibiotic concentration on the rate of evolution of bacteria. As you can see, it is in the stage of low antibiotic concentration where the rate of evolution is highest.
This is why it is so important to be extremely careful with antibiotics and to
Thank you!
Ayelet Teitelbaum
10th Grade
My Mentor
My Project
My Project
My MAGICal Experience
My Demo
Informational website home page
Thank you!
Riki Posner
10th Grade
My Mentor
My Project
My MAGICal Experience
My Demo
Google Doc
First Page
Learn More
Thyroid Page
Code
Question
Thank you!
Priva Halpert
10th Grade
My Mentor
My Project
Alcohol Detection Using Image Analysis and Color Changing Methods (squarine and BODIPY dye)
In what way will various alcohols react with nonpolar, highly colored dyes, particularly in the presence of cyclodextrin?
Introduction
Introduction
System Developed
The system developed relies on the structural features of the alcohols, in order to cause a color change in the overall solution that contains a dye and cyclodextrin host. Alcohol molecules of this type have both a non-polar and a polar section of the molecule. As a result of these properties, one can cause the alcohol to bind in cyclodextrin molecule, which is a group of glucose molecules all linked together in a ring.
When placed in a polar solvent such as water, the non-polar sections of the glucose group together to form a ring-shaped figure, in which the center is nonpolar and the outside is polar. When the water, alcohol and cyclodextrin are combined in a solution the alcohol positions its non-polar section within the center of the cyclodextrin ring, which is nonpolar, and the polar part of the alcohol sticks out into the polar water environment.
System Developed
Adding a nonpolar dye (sanguine and BODIPY- boron-dipyrromethene)to a solution with cyclodextrin causes a color change in the dye, because the dye is attracted to the inside of the ring and positions itself there. After adding the alcohol, the dye is kicked out of the ring in order to make room for the alcohol. This change in the molecular environment of the dye causes the solution to appear to be a different shade than before.
System Developed
Ethyl Alcohol
n-Butyl Alcohol
Isopropyl
Alcohol
2-hydroxypropyl-β-cyclodextrin
Boron-based dye
(BODIPY)
Squaraine dye
Molecule Modeling
Molecule Modeling
BODIPY in alpha cyclodextrin
BODIPY in beta cyclodextrin
BODIPY in gamma cyclodextrin
NOTE: in this study beta cyclodextrin was used
Image Analysis
1- isopropyl with cyclodextrin
3- n-butyl
3- n-butyl with cyclodextrin
2- ethyl
2- ethyl with cyclodextrin
1- isopropyl
WATER VALUES (CD)- CONTROL VERSUS ALCOHOL VALUES (CD) | ||||||
anlyte | R | G | B | H | S | L |
1: isopropyl | 183.00 | 170.00 | 15.00 | 55.00 | 85.00 | 39.00 |
2: ethyl | 161.00 | 164.00 | 3.00 | 61.00 | 96.00 | 33.00 |
3: n-butyl | 176.00 | 188.00 | 23.00 | 64.00 | 78.00 | 41.00 |
4: water | 170.0000 | 169.0000 | 167.0000 | 40.0000 | 2.0000 | 66.0000 |
Data
Comparison of the separate analytes
COMPARISON OF CD v noCD ON RGB PER ANALYTE
Data
Comparison of the separate analytes
Data
Comparison each analyte CD v noCD
COMPARISON OF THE ANALYTES (CD AND noCD SEPARATELY COMPARED)
As can be seen in the data obtained through this study, there is a significant difference between the effects of the addition of cyclodextrin to various alcoholic analytes, as well as a significant difference between the analytes themselves with cyclodextrin and without. Therefore my hypothesis was supported by the findings of this study. This new data can be used for various purposes, including but not limited to alcoholic testing, bacterial testing and health screening.
This study was very helpful in determining and analyzing the different interactions between alcohols and various other substances. In conclusion, we found that alcohols are very receptive to color change. There was not a very large difference between the solutions containing cyclodextrin as opposed to those without, although there was a significant difference between the interactions of the different alcohols and dyes. This technique can be used to determine what alcohol exists within a solution, as well as its concentration.
Conclusion
Thank you!
Eliana Millstone
12th Grade
My Mentor
Website
First Page
Website
Statistics
Website
Photo Gallery
Introduction
My Project
My Results
Time spent charging (min) | Time it ran for (sec) |
1 | 32 |
2 | 59 |
5 | 142 |
10 | 287 |
My Results
Round # | How long solar panel runs for (sec) | How long battery runs for (sec) |
1 | 112 | 142 |
2 | 107 | 135 |
3 | 99 | 151 |
4 | 103 | 139 |
Charged the water with either the solar panel or battery for 5 minutes.
Videos
Charging the water
Car running
My MAGICal Experience
Thank you!