Numerical Experiments in compuGUT
By, Andrew Mueller in collaboration with Professor Melara
and Dr. A. J. Kearsley (NIST)
Program created by Dr. Arun Moorthy under advisement of Professor Eberl
Background of compuGUT:
compuGUT Parameters
Complete Mathematical Model:
Closeup of Basic Irregular Diet
Lumen Environment
Biomaterials in Lumen Environment
Mucus Environment:
Biomaterials in Mucus Environment
Location in Colon [m]
Total Mass of Particulates [g]
Total Mass of Particulates [g]
Concentration of
Compounds[g/L]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Concentration of
Compounds[g/L]
Perturbing Parameter Values
Modified Program:
ADM1
Inocula (IC)
Diet
Parameters (Text Files [.txt])
Operation Instructions
compuGUT - Integration (C code [.c])
Results (Text Files [.txt])
ccm_r####
PreColon
Time Values
Sim Summary
Sim Parameters
Interactive Results (R Markdown File [.RMD])
Plot of Results (HTML File [.html])
Interactive Error Results (R Markdown file [.RMD])
Plot of Error (HTML File [.html])
Run (Bash Script [.sh])
Perturb Parameters (Bash Script [.sh])
Sensitivity by perturbing parameters by 0.001:
p0 + 0.001:
p9 + 0.001:
Lumen Environment
Lumen Environment
Lumen Environment
Lumen Environment
Mucus Environment
Mucus Environment
Mucus Environment
Mucus Environment
Total Mass of Particulates [g]
Mass of Particulates
Total Mass of Particulates [g]
Total Mass of Particulates [g]
Concentration of
Compounds[g/L]
Concentration of
Compounds[g/L]
Concentration of
Compounds[g/L]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Location in Colon [m]
Concentration of
Compounds[g/L]
p26 + 0.001:
Lumen Environment
Total Mass of Particulates [g]
Location in Colon [m]
Mucus Environment
Total Mass of Particulates [g]
Location in Colon [m]
Concentration of
Compounds[g/L]
Location in Colon [m]
Lumen Environment
Mucus Environment
Concentration of
Compounds[g/L]
Location in Colon [m]
Conclusions