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Particle therapy masterclass �LASA and INFN-MI group

Therapy planning for Liver cancer and Prostate cancer

Sereni

ITIS Feltrinelli

Donatelli-Pascal

IIS Severi Correnti

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STUDENTS

Sara Ingegnere

Luca Donello

Pellitteri Gaetano

Beatrice Ceron

Emma Reggiori

Davide Mardegan

Arianna Baldioli

Chiara Crivelli

Ariel Belletti

Anna Belloni

David Brambilla

Lorenzo Serafino

Matteo Romano

Sara Ataide

Tommaso Sceppascerca

Yang Yijing

Giulia Zardini

Saffiya El Guerr

Giacomo Vicentini

Mordeglia Luca

ISIS A. Ponti

Leone XIII

Bachelet

IIS Gadda

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TABLE OF CONTENT

Liver cancer – comparison between single and multiple photons beams

Liver cancer – comparison between photons, protons and carbon ions beams

Prostate cancer – comparison between single and multiple photons beams

Prostate cancer – comparison between photons, protons and carbon ions beams

Prostate cancer – dose delivery to OARs as a function of the angle for a single photons beam

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Liver cancer �Comparison between single and multiple photons beams

Three beams

Five beams

We chose 35-190-210 degrees using 3 photons beam in order to avoid the OAT (heart and spinal column)

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We selected 5 beams close to 0 and 180 degrees to avoid to irradiate the heart and the spinal cord

Single beam

After various attempts we noticed that the right values, using a single photon beam ,fluctuated close to 180 degrees.

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Liver cancer �Comparison between single and multiple photons beams

Three beams

Five beams

  • GRUPPO 2 - graph

Single beam

  • GRUPPO 1:

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Liver cancer �Comparison between single photons and single protons beams

Photon therapy

Proton therapy

Using a 180 degree direction, centred in the isocentre of the tumoral mass, we found these values.

Carbon ion therapy

Add your graph *here*�

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Liver cancer �Comparison between photon, proton therapy and carbon ion therapy

Proton beam

Carbon ions beam

Five photons beams

  • GRUPPO 4: add DVH

LIVER: We tried with the paper’s assignment of 5 photon beams of respectively 0-180-225-270-315 deg.�

LIVER: We discovered that with only 1 carbon beam, angled at 0 deg gives us a much better result

LIVER: We tried with the paper’s assignment of one proton beam of 180 deg.�

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Prostate cancer �Comparison between single and multiple photons beams

Three beams

Five beams

We used the angles 95 180 and 265 but we noticed an higher value of the dose around the zone of the bladder and on the skin.

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We used the angles 60 90 180 270 300 and obtained an optimal result.

Single beam

We tried with a beam of photons and different angles. 0 degrees is the best angle but is still not optimised. This is because the maximum dose is taken by the bladder and skin, not by the tumor.

Add your graph *here*�

Add your graph *here*�

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Prostate cancer �Comparison between single photons, protons and carbon ion beams

Photon therapy

Proton therapy

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We tried with a beam of protons and different angles to find the best option. We found out that 80 degrees is the best one optimizing the result with less damages to the other organs.

We tried with a beam of photons and differents angles. 0 degrees is the best angle but is still not optimised. This is because the maximum dose is taken by the bladder and skin, not by the tumor.

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Carbon ion therapy

We tried 4 angles in order to reduce the radiation damage to the bladder, rectum,and femoral heads.

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Prostate cancer �Comparison between photon, proton therapy and carbon ion therapy

Proton beam

Carbon ions beam

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Five photons beams

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Add your graph *here*

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Add your graph *here*�

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Prostate cancer �Dose delivery to the oars as a function of the angle for a single photon beam

 

Mean dose (Gy)

 

PTV

Bladder

Rectum

0°

2,1216

 1,8692

 1,2706

25°

2,1100

 2,1280

 1,4466

50°

2,1632

 2,0136

 1,4622

75°

2,1769

2,3080

1,3729

100°

2,1731

2,1166

1,4064

125°

2,1055

1,4663

1,9324

150°

2,0980

1,4923

1,9375

175°

2,1058

1,3037

1,6685

200°

2,0963

1,3960

1,7763

225°

2,1055

1,4663

1,9324

250°

2,1410

1,2292

1,6173

275°

2,1692

1,0810

1,2877

300°

2,1710

1,7300

1,4133

325°

2,1394

2,1904

1,4909

350°

2,1205

1,9565

1,3048

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Prostate cancer �Dose delivery to the oars as a function of the angle for a single photon beam

dose

angle

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Conclusions

Comparing single photons and single protons, the latter avoid the tissues after the tumor

Between one photons beam and 5 photons beams we noted that 5 beams reduces the dose at the skin

The andvantages of carbon ion beams compared to proton and photon are reduced dose in the entrance of the body

The advantages of photons are the availability of large number of centers in the world

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Thank you �for your attention!