Chronic Vitamin A Toxicity Is a Modern Epidemic
THE UNDENIABLE RESEARCH
The epidemic we were warned about...
...is now here.
The presentation today will cover:
In the future, I will be doing a longer video covering even more evidence.
Past Warnings of What Was to Come
First warning about future Vitamin A toxicity:
Hypervitaminosis A. (1948)
“The current popularity of vitamins--widely advertised and consumed in great quantity the country over--directs the attention of physicians to the question of their misuse. The report of additional cases of hypervitaminosis A may result in either a reduction in the strength of this vitamin in commercial preparations or the use of a label warning against the dangers of over-dosage. Still other measures may be desirable. To paraphrase a comment made by Josephs: One safeguard we lack is protection of the public against the evangelic zeal of persons who have been sold on vitamins.”
Second warning about future Vitamin A toxicity:
Masked Hypervitaminosis A and Liver Injury (1982)
“With rampant food faddism, the medical indications for treating acne vulgaris with vitamin A and the recent push given to the still controversial preventive role of retinoids in carcinogenesis, we may be on the verge of an epidemic of vitamin A toxicity.”
“Gold Standard” Vit A Toxicity Testing�...and Everything Else
What is the “Gold Standard” Test for Vit A Toxicity?
The gold standard test for Vitamin A (VA) toxicity is liver biopsy, and only liver biopsy.
Assessing Vitamin A Status: Past, Present and Future
“Direct measurement of liver reserves of vitamin A status, the “gold” standard, through biopsy will never be a field friendly indicator and therefore has limited utility in the real world.”
A survey of human liver reserves of retinol in London.
“It is generally accepted that the most direct and accurate method of assessing vitamin A status is to measure the concentration of the vitamin in the liver, since it is in this organ that 90% or more of the body’s reserves are located. However (and particularly from the viewpoint of field surveys) the tissue in question is usually inaccessible in living persons because, for ethical reasons, liver biopsies can be performed in only a limited number of clinical situations.”
What is a liver biopsy?
The surgeon takes a chunk of your liver.
May be done with a large needle while you�are alive, or...
...the following studies did their liver biopsies�on cadavers via autopsy/necropsy.
After obtaining the sample, the researchers �analyze it for Vitamin A compounds.
I don’t want it done to me, you don’t either!
Hence the “limited utility” mentioned earlier.
Why not use blood tests for Vit A toxicity?
Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective
“Serum retinol concentrations (normally 1–3 μmol/L) do not reflect hepatic vitamin A concentrations over a wide range of liver values, since the secreted RBP is under homeostatic control. Thus serum retinol concentrations vary little despite major alterations in vitamin A intake. Case reports of hypervitaminosis A often show serum retinol concentrations within normal limits, indicating that serum retinol is not a valid measure of vitamin A status during toxicity.”
Because they suck at assessing toxicity, that’s why.
Important notes on the following studies:
The following studies used liver biopsies, done during autopsy/necropsy, with bodies (cadavers) of people who passed due to either accidental causes and/or chronic disease (ie. it’s not just “sick people”).
The modern accepted standard of VA (retinol plus retinyl esters) toxicity in liver tissue is > 1 umol VA per gram of liver tissue (1 umol/g aka 1 micromol/g).
Some studies used different units, and the converted levels of toxicity in other units are as follows (for those who look into the references):
Toxicity was typically assessed for our purposes by liver VA levels being above 1 umol/g, above 1000 i.u./g, or above 300 mg/kg. There are some exceptions, mainly due to limitations in the data.
The Two Most Recent Studies First
Vitamin A Toxicity in the US, ***2018***
“Cadaver liver samples were analyzed to explore VA status biomarker associations in US adults.�[...]�Nine subjects (33%) had hypervitaminosis A (≥1.0 μmol VA/g liver)...[27 total subjects]�[...]�The WHO often uses a 20% prevalence to define a severe public health concern.�[...]�Chronic VA toxicity can occur from ingestion of moderate levels of preformed VA for months or years.�[...]�The hypervitaminotic A concentrations discovered in these subjects would not have been identified by currently applied serum indicators.”
Vitamin A Toxicity in Singapore, 1988
Vitamin A reserve of liver in health and coronary heart disease among ethnic groups in Singapore (1988)
Percentages above 300 mg/kg: [toxicity is > 286 mg/kg]
“At the extreme end of the range, 9% of the subjects had concentrations above 500 mg/kg and 1% of the subjects had concentrations above 1000 mg vitamin A/kg in the liver.”
[...]�The ethnic distribution of vitamin A reserve in coronary deaths was similar to that in accident victims. There was no significant difference between the sexes in hepatic vitamin A reserve.” �
More VA Toxicity Studies
In Chronological Order
Vitamin A Toxicity in New Zealand, 1951 & 1960-61
Vitamin A content of human liver from autopsies in New Zealand.
27.9% [31 / 111] subjects were above 900 IU/g. Toxicity is > 952 i.u./g.
“Children from 1 to 10 years had markedly higher liver stores (with a median value of 1982 i.u./g) than other groups...”
“The exceptionally high value for a young adult of 10,438 i.u./g, associated with an unusually high daily prescription of vitamin A...”
“In thirty-nine children dying under 10 years of age [...] were some unusually high values, e.g. 4720 and 6878 i.u./g.”
“The findings are ascribed to a liberal intake of butter, a dietary with ample vitamin A and carotene, and the wide use of medicinal preparations containing or made from fish-liver oils, particularly for infants and children.”
Vitamin A Toxicity in Ghana, 1963 & 1967
HYPERCAROTENÆMIA IN GHANAIANS. �“The vitamin-A content of the forty-nine livers varied considerably-from 32 ug/g. to 3635 ug/g. Twenty-four of the livers showed vitamin-A levels above 300 ug/g, while the average concentration for the whole group was 409 ug/g.” [Toxicity is > 286 ug/g]
49% [24 / 49] subjects were above 300 ug/g. HALF of the subjects are Vitamin A toxic.
Distribution of carotene and vitamin A in liver, pancreas and body fat of Ghanaians.
In 17 subjects, the median value was 350 ug/g, with 12% over 900 ug/g. This means that again, HALF the subjects were Vitamin A toxic!
Is Africa actually deficient in Vitamin A, as we are made to believe?
Vitamin A Toxicity in Canada, 1969
Vitamin A Reserves of Canadians
451 subjects, percentages over 240 ug/g, in relation to province: [toxicity is > 286 ug/g, data only covered > 240 ug/g]
“Children between 1 and 10 years of age had the highest vitamin A stores.” [mean = 304.0 ug/g, median 247.6 ug/g]
Vitamin A Toxicity in New York City, 1970
10 / 101 (10%) of the livers tested were above 300 ug/g. Toxicity is > 286 ug/g.
“One specimen from a 31-year-old white female had a very high concentration of vitamin A, 1,000 ug/g tissue.”
Vitamin A Toxicity in Washington DC, 1973
Vitamin A and carotene levels of a selected population in metropolitan Washington, D. C.
Toxicity is above 286 ug/g.
Regardless of race, sex. or cause of death: 24.2% [80 / 329] subjects above 300 ug/g.
In relation to race and sex, percentages above 300 ug/g:
Vitamin A Toxicity in London, England, 1977-1978
A survey of human liver reserves of retinol in London.
112 / 364 (31%) of subjects were over 300 ug/g. Toxicity is above 286 mg/kg.
“...forty subjects (11.0% of the survey population) had reserves above 500 mg/kg, and three of these individuals had reserves in excess of 1000 mg/kg.”
How much VA toxicity is happening worldwide?
Overlapping vitamin A interventions in the US, Guatemala, Zambia, and South Africa: case studies.
Repeat: Liver biopsy--the gold standard test--from 27 U.S. adult cadavers revealed 33% prevalence of hypervitaminosis A (defined as ≥1 μmol/g liver). 1 out of every 3 people, that’s an epidemic!
In 133 Zambian children, 59% were diagnosed with hypervitaminosis A, and 16% had >5% total serum VA as retinyl esters (another marker of VA toxicity). 6 out of 10 kids!
In 40 South African children who frequently consumed liver, 72.5% had >5% total serum VA as retinyl esters. 7 out of 10 kids!
All three of those countries encourage high carotenoid consumption, have mandatory fortified foods, and a high % of supplement users or targeted supplementation to preschool children.
The General Effect of Vitamin A in
Well-Nourished People
Do you consider yourself a well-nourished person?
The neurotoxic effects of vitamin A and retinoids (2015)
“Nonetheless, it has been demonstrated that vitamin A intake among well-nourished subjects may lead to decreased life quality and increased mortality rates (Bjelakovic et al. 2007, 2008, 2012, 2014).”
Translation...in well-fed people, Vitamin A equals:
In Summary...
We were warned an epidemic of Vitamin A toxicity was coming.
“Gold standard” liver biopsy testing shows us the epidemic is HERE NOW.
Epidemic toxicity levels are evident in multiple countries over multiple decades.
Blood tests will not show you if you are toxic or not with VA in your liver.
Food VA causes toxicity just as well as synthetic VA, see New Zealand study.
If you have any chronic health issues, you are extremely likely to be dealing with chronic VA toxicity. This includes heart disease, cancer, and autoimmunity.
How Do We Fix This Problem?
Eat organic and drink properly filtered water to avoid glyphosate.
Reduce all of your exposures to Vitamin A:
Decrease foods that slow down your liver’s detox pathways (many are falsely thought to be “healthy”!).
Increase specific nutrients that carry the VA out of your body (most important!)
All of these aspects are covered in the Vitamin A Toxicity and Detoxification Network at https://nutrition-restored.mn.co.
Want More Info On How To Fix Your Vit A Toxicity?
My website: https://NutritionRestored.com
Other videos:�YouTube (Nutrition Restored): https://www.youtube.com/nutritionrestored�BitChute (NutritionRestored): https://www.bitchute.com/channel/qngkhn3Cw83E/
FaceBook: https://www.facebook.com/DoctorAsTeacher
Vitamin A Toxicity and Detoxification Network: https://nutrition-restored.mn.co