IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars

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Aug 26, 2021

Welcome - The meeting will start at 3PM EDT

NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND

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Agenda

1. Welcome
2. Links, people, other info
3. Social media links
4. Quick Announcements
5. Upcoming Mini-Seminars and Request for Future Speakers
6. Group Discussion on the Future of the VPWG
7. Request for Further Business

People

Co-Lead: Reinhard Laubenbacher, PhD

Department of Medicine

Laboratory for Systems Medicine

University of Florida

reinhard.laubenbacher@medicine.ufl.edu

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Co-Lead: James A. Glazier, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jaglazier@gmail.com

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Web Administration, Slack: James P. Sluka, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jsluka@indiana.edu

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Activities Coordination: Bruce G. Shapiro, PhD, PMP

Laboratory for Systems Medicine

University of Florida

bruce.shapiro@medicine.ufl.edu

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Slack Channel

https://Msm-working-group.slack.com

Twitter

https://twitter.com/MsmViral

Our IMAG/MSM Wiki page

https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!

Or, use the Tiny URL: https://tinyurl.com/hkr97vfe

IMAG’s LinkedIn

https://www.linkedin.com/groups/12095434?lipi=urn%3Ali%3Apage%3Ad_flagship3_search_srp_all%3B1FVndkN2SD6P0xj2PYfqdQ%3D%3D

YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw

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Announcements

�Any short (~1 minute) items such as;

• announcements
• meetings
• funding
• publications
• requests for help
• ???

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Schedule for Upcoming Meetings and mini-Seminars

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Sept 2:

1. Harry Hochheiser,University of Pittsburgh School of Medicine, Principal Investigator of the MIDAS coordinating center. Efforts of the Coordinating Center around data provisioning, data models, FAIR data, and some of the possibilities that we envision for infectious disease modeling data.
2. Dr. Guido España, University of Notre Dame

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Request for future speakers (Aug 26, …)

�Group Discussion on the Future of the VPWG

Google doc for discussion points:

https://docs.google.com/document/d/1V4Fs7HmMGth3Z1vordb8TwGa4ODzL_AVZrNn2lNc6hk/edit?usp=sharing

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1. Role of the WG
2. Activities
3. Expertise and Community Building
4. Scientific Aims

(20 minutes each)

�Role of the WG

• What is an appropriate role for the WG vis-a-vis the many other organizations related to either MSM or to infectious disease and immune response?
• Reed Shabman: The group, given the grass roots support has been a major success, in terms of content, participation and visibility.

Activies

• What are some appropriate activities for the coming year?
• Reed Shabman: be ready for contributing to the IMAG meeting, even though it’s delayed from the initial plan
• Are there specific activities that we could develop which would be valuable and increase impact/engagement?
• Reed Shabman: Consider moving to once every two weeks. A workshop that occurs at the same time as the seminar. Could be for a couple of sessions. Send a calendar invite instead of registration.
• MJ Colebank: In light of the annual IMAG/MSM meeting, would it be possible to organize a MSM-VP meeting with potential funding from a R13/U13 NIH grant?
• J Rice and J Sluka: develop a “Co-op” or “Collabatorium” where models and data can be shared. Enable online execution, sharing data, etc.

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Expertise and Community Building

• What projects would leverage this collection of expertise most effectively?
• MJ Colebank: Schedule brainstorming sessions between researchers/groups that work at the interface between model scales. E.g.:
• those working on models of inflammatory cascades at the cell level meet with individuals simulating whole body adaptation to increases in inflammatory agents;
• Individuals with expertise in epidemiological spread at the county/state level work with those who model within host development of disease
• Reed Shabman: Continue trying to foster interactions between computational modelers and pure biologists. The main points in the modeling community can continue to be addressed by interactions with these groups.

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Scientific Aims

Are there other scientific aims or foci that would match our community interests better, expand our community or make our activities more effective? What other scientific aims should we focus on that would bring in more active members?

• MJ Colebank: Towards the end goal of digital twins, mechanistic and statistical models need to be tested against patient data. One of the current areas of open research in physiological modeling is understanding parameter inference, parameter identifiability, and model uncertainty.
• To recruit more active members perhaps we should emphasize a subgroup dedicated to parameter inference and model uncertainty.
• This would still focus on deriving mechanistic, multiscale models of viral pandemics, but with greater emphasis on parameter identifiability, which is necessary if one wants to consistently integrate serial data recordings in a digital twin.

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