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Subcutaneous Device for Asthma Attacks Prevention

María del Valle Blázquez Romero, Adrián Gómez Aldudo, Sebastián Huerta, Gabriel Iglesias, Antonio Sánchez Salgado

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Asthma Statistics

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Asthma patients are forced to carry their inhalers everywhere and if they were to suffer from an asthma attack, they would have to self-administer the treatment which increases the likelihood of human-error leading to inaccurate drug administration.

Prior Art:

Design Goals:

​

#1 Must be minimally-invasive

#2 Must have dimensions no greater than 3 mL

#3 Must reduce bronchiole inflammation

#4 Must be biocompatible

#5 Must not compromise user’s quality of life

Inaccurate Administration of Asthma Medication

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Concept Variants

Selection Criteria

Reference

(Inhaler)

Subcutaneous device

Micro-particles filter device

Bronchial Mesh

Low-level laser therapy

Biocompatibility

0

3

3

2

3

Minimally-invasive

0

2

2

2

1

Ease of maintenance

0

4

2

2

3

Physical durability

0

5

3

1

1

Time of development

0

3

2

5

3

Novelty

0

3

4

5

5

Cost

0

3

2

1

3

 

 

 

 

 

 

Total score

0

26

20

18

19

Ranking

5

1

2

4

3

Continue?

No

Yes

Revise

No

Revise

Pugh Chart Pointed to a Subcutaneous Device

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Block Diagram, Critical Subcomponents

Detection

Biosensor wireless signal transmission

Circuit activates battery & motor

Container

Threaded bar rotates

Piston goes down

Highly concentrated solution of bronchodilator salbutamol

Energy

Stimulus (cytokines concentration)

Bronchodilator drug release

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Cytokines detection triggers the response

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Block Diagram & Critical Subcomponents

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Block Diagram & Critical Subcomponents

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Block Diagram & Critical Subcomponents

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Battery

Motor

H-Bridge

Switch

Potentiometer

Circuit Detects Signal and Activates Motor

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Ø = 3.5 mm

Ø = 0.1 mm

10 mm

50 mm

Cylindrical container

Truncated cone

Piston

Threaded bar

Structural Design and Dimensions

Design Goal #2: “Must have dimensions no greater than 3 mL”

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3D SolidWorks Animation

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Design Goal #4: “Must be biocompatible”

SolidWorks Design & Material Selection Analysis

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Dose Release Calculation

Design Goal #3: “Must reduce bronchiole inflammation”

​

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Dose Release Calculation

Design Goal #3: “Must reduce bronchiole inflammation”

​

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Minimally-invasive procedure

Design Goal #1: “Must be minimally-invasive”

​

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Limitations: Next Steps

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Conclusions

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Thanks!

Any question?