Hippocrates
Men think epilepsy divine, merely because they do not understand it. We will one day understand what causes it, and then cease to call it divine. And so it is with everything in the universe.
Www.azquotes.com/quotes/topics/epilepsy.html
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET 2025 - NEW ORLEANS
Www.PNDPocketNeuroDiagnostics.com
Petra N. Davidson, BS, R. EEG/EP T., CLTM, FASET
Owner of PND Pocket Neurodiagnostics, LLC
Staff Technologist at Northeast Georgia Physician’s Group, Buford, GA
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
Your Handouts
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
Summarize the lecture.
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
ASET Annual Conference 2025
New Orleans, LA
Petra N. Davidson, BS, R. EEG/EP T., CLTM, FASET
Reflex Seizure Type | Visual/ Photosensitive | Musicogenic or Audiogenic | Hot Water/ Bathing | Reading | Praxis | Somatosensory | Eating | Proprioceptive | Orgasm |
Provocation Stimuli | Specific light, pattern, or sequence of lights | Specific song or sound | Hot water to the head or submersed | Specific passage/ text | Mahjong, Chess, Math | Legos, Diaper Changing, or other tactile stimuli | Specific smell/ taste | Single type of movement, walking, running, jumping | Only to sexual orgasm |
Primary Ideal Treatment | Avoidance Modification Valproic Acid | Avoidance Carbamazepine or lamotrigine | Modification Clobazam | Modified Valproic Acid or clonazepam | Avoidance Modification Sodium Valproate | Focal seizure medications: lamotrigine, levetiracetam, carbamazepine | Modification Clobazam | Insulin therapy Carbamazepine or clobazam | Focal seizure meds or surgery |
Associated Epilepsy Syndromes | JME, CAE, JAE, IGE, IPOE, PME, DS | Epileptogenic lesions with ADTLE | None | GGE, JME | GGE | MCD, post-central cortical lesions | Epileptogenic lesions | Acquired lesions; non-ketotic hyperglycemia, acute diffuse encephalopathies | Acquired lesions |
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET – NOLA 2025
Davidson
Reflex Seizure Type | Visual/ Photosensitive | Musicogenic or Audiogenic | Hot Water/ Bathing | Reading | Praxis | Somatosensory | Eating | Proprioceptive | Orgasm |
Seizure Type | Absence, myoclonia, GTCS, focal- occipital | Temporal lobe | Focal | Jaw myoclonus, to GTCS | Myoclonia, absence, GTCS | Sensory aura, Jacksonian sz with tonic motor activity, 2nd gen | Focal w/wo impaired awareness | Myoclonic or somatosensory szs, Focal to Bilateral | Focal |
Regional | | | Southern India and Turkey | | Mahjong -Asia | | Sri Lanka | | |
Gender predominance | Female | Females | Male | Male | N/A | N/A | Male | N/A | Female |
Prevalence | 1/4000 | 1/10,000,000 | Rare | Rare | Overlaps with JME | Rare | 1/1000 | Rare | VERY rare |
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET – NOLA 2025
Davidson
Petra N Davidson, BS, R. EEG/EP T., CLTM, FASET
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Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
6/11/2025
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Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
Reflex Seizures and Epilepsies - what are they, how are they defined?
1
What types of reflex seizures have been identified?
2
How do we elicit reflex seizures and epilepsies in the clinic, EMU, ICU, wherever we need?
3
Treatment methods and how to evaluate them during monitoring.
4
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
Your Handout
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
What are Reflex Seizures?
Types of Reflex Seizures
Eliciting Reflex Seizures
Treatment methods & evaluation
Reflex Seizures
Italiano et al, 2014:
Reflex seizures are:
Italiano et al, 2016:
Reflex seizures in humans:
Each patient tends to have just 1 type of reflex seizure but may have other seizures as well.
Reflex Seizures
Italiano et al, 2014:
Reflex seizures are:
Italiano et al, 2016:
Reflex seizures in humans:
Each patient tends to have just 1 type of reflex seizure but may have other seizures as well.
Reflex Epilepsy
4-7%of all epileptic patients have reflex epilepsy.
Okudan and Ozkara 2018
Reflex Seizures
Italiano et al, 2014:
Reflex seizures are:
Italiano et al, 2016:
Reflex seizures in humans:
Each patient tends to have just 1 type of reflex seizure but may have other seizures as well.
Reflex Epilepsy
4-7%of all epileptic patients have reflex epilepsy.
Okudan and Ozkara 2018
Photic Induced
Photosensitive epilepsy occurs in 2-5% of all epileptic patients.
Reflex Seizures
Italiano et al, 2014:
Reflex seizures are:
Italiano et al, 2016:
Reflex seizures in humans:
Each patient tends to have just 1 type of reflex seizure but may have other seizures as well.
Reflex Epilepsy
4-7%of all epileptic patients have reflex epilepsy.
Okudan and Ozkara 2018
Photic Induced
Photosensitive epilepsy occurs in 2-5% of all epileptic patients.
Regional
Less than 1% of all epileptic patients have hot water epilepsy, however, HWE occurs 3.6-6.9% in Southern India.
Reflex Seizures
What & How
A seizure is...
01
a transient (fleeting) occurrence of
symptoms (things the patient feels) and/or sign (things witnesses see)
due to abnormal excessive or synchronous neuronal activity in the brain.
Reflex Seizures
What & How
A reflex seizure is ...
01
a transient (fleeting) occurrence of
symptoms (things the patient feels) and/or sign (things witnesses see)
due to abnormal excessive or synchronous neuronal activity in the brain.
elicited by a very specific trigger, often in a specific environment with other conditional changes.
Reflex Seizures
What & How
The only reflex seizure included in the 2021 ILAE nosology is...
01
EwRIS, epilepsy with reading induced seizures
the only reflex seizure to have consistent electroclinical features, etiologies, and prognosis.
https://www.ilae.org/files/dmfile/onset-at-a-variable-age2.pdf
ILAE Position Statement on Variable Age Onset Epilepsy Syndromes
Reflex Seizures & Epilepsies
Both must be elicited by a specific trigger consistently.
Both must fit the definition of seizures and/or epilepsy.
Hanif and Musick, 2021 - epileptic events that are objectively and consistently elicited in response to a specific stimulus or by a patient activity.
Hanif and Musick, 2021 - specific syndrome in which ALL seizures are elicited by sensory stimuli.
Reflex Seizures
Types
02
Types of Reflex Seizures
Elementary
or
Complex
Basic stimulus
simple flash of light
single tone sound
tap/simple touch
smell/taste
Detailed stimulus
Patterned fabric
Musical composition
Tickle/Massage
(no documented variety)
Types of Reflex Seizures
Somatosensory
Legos
Diaper Changes
Touch
Somatosensory Stimuli
Orgasm
Only to orgasms
Gustatory
Eating
Other
Dental treatment
Startle Induced
Hot Water
Bathing
Reading
Reading
Speaking
Writing
Language Activities
Praxis
Praxis
Thinking
Math
Chess
Auditory
Musicogenic
Elementary sounds
Visual
Photosensitivity
Reading
Sunlight
Complex Patterns
Olfactory
Coffee
Paint
Complex smells
Reflex Epilepsy and the Value of Unique Activation Methods in the Monitoring Unit
Your Handout
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET – NOLA 2025
Davidson
Photosensitive Types
Musicogenic Types
Reading Types
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET – NOLA 2025
Davidson
Eating Types
Bathing Types
Somatosensory Types
Reflex Epilepsy & The Value of Unique Activation Methods in the EMU
ASET – NOLA 2025
Davidson
Thinking Types
Praxis Types
Proprioception Types
Photosensitive Epilepsy
Musicogenic Epilepsy
Reading Epilepsy
Eating-Induced
Hot Water or Bathing
Orgasm
Somatosensory
Noogenic
Math
Startle
Praxis
Proprioception
Reflex Seizures
Eliciting them in the lab
Goldilocks' principle
03
Eliciting RS/RE in the lab
Eliciting RS/RE
Elicitation of RS/RE is going to depend on:
1
First event, all details about events, most recent event, treatments attempted
2
3
Thorough history
Common time of day, common situations common sounds/sights/smells/tastes/activities
Identifying common scenarios
Encouraging sleep deprivation, known stressors, presenting all possible stimulants
Replicating situation
Photosensitive Epilepsy
Musicogenic Epilepsy
Reading Epilepsy
Eating-Induced
Hot Water or Bathing
Orgasm
Somatosensory
Noogenic
Math
Startle
Praxis
Elicitation Protocol
Writing
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Elicitation Protocol
Writing
Speaking
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Elicitation Protocol
Writing
Speaking
Other Verbal
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Elicitation Protocol
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Elicitation Protocol
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Okuma et al 1980
Constructional Praxis
Praxis Induction by Yacubian and Wolf 2014
Elicitation Protocol
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Okuma et al 1980
Constructional Praxis
Other Tests
Praxis Induction by Yacubian and Wolf 2014
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Constructional Praxis
Other Tests
Elicitation Protocol
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Uchida-Kraepelin
Test
Test used to asses ability to learn & personality, induce stress
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Constructional Praxis
Other Tests
Elicitation Protocol
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Constructional Praxis
Other Tests
Elicitation Protocol
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Constructional Praxis
Other Tests
Elicitation Protocol
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Bourdon Cancellation Test
Writing
Speaking
Other Verbal
Calculation
Addition, Subtraction, Multiplication, Division
Constructional Praxis
Other Tests
Elicitation Protocol
Okuma et al 1980
Praxis Induction by Yacubian and Wolf 2014
Proprioception
Reflex Seizures
Monitoring the Treatment
Okudan and Ozkara provide a list of the individual treatments for each of these 9 major types of reflex seizures.
04
Treatment
Modification
Avoidance
Medication/Surgery
Photosensitive Epilepsy
Musicogenic Epilepsy
Reading Epilepsy
Eating-Induced
Hot Water or Bathing
Orgasm
Somatosensory
Noogenic
Use same medication as with Genetic Generalized Epilepsies
Math
Typically use same medication as with Genetic Generalized Epilepsies
Startle
Praxis
Proprioception
Thank You
For 25 years, I’ve enjoyed ASET and Neurodiagnostics.
For more than 15 years, I’ve loved reading and writing for our journal. And for nearly a year, I’ve been enthralled in mentoring board prep through my own business. You never know where this can take you. Thanks!!
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