IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars
Feb 24, 2022
Welcome - The meeting will start at 3PM ET
NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND
Agenda
People
Co-Lead: Reinhard Laubenbacher, PhD
Department of Medicine
Laboratory for Systems Medicine
University of Florida
reinhard.laubenbacher@medicine.ufl.edu
Co-Lead: James A. Glazier, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Web Administration, Slack: James P. Sluka, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Activities Coordination: Lorenzo Veschini, PhD
King’s College London
Slack Channel
https://Msm-working-group.slack.com
Our IMAG/MSM Wiki page
https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!
Or, use the Tiny URL: https://tinyurl.com/hkr97vfe
IMAG’s LinkedIn
YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd
Please follow the�group on Twitter!
If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.
Announcements
�Any short (~1 minute) items such as;
Schedule for Upcoming Meetings and mini-Seminars
March 3:
March 10:
March 17:
March 24:
Request for future speakers (March 3, 10, …)
Rules of the Meeting
Please mute your microphone and hold questions until after the presentations
Mini-Seminar�Modeling across-scale feedbacks of infectious diseases
Hayriye Gulbudak�University of Louisiana at Lafayette
A current challenge for disease modeling and public health is to understand pathogen dynamics across infection scales from within-host to between-host. Viral and immune response kinetics upon infection impact transmission to other hosts and feedback into population-wide immunity, all of which influence the severity, trajectory, and evolution of a spreading pathogen. In this talk, I will introduce structured partial differential equation models linking immunology and epidemiology in order to investigate coevolution of virus and host, multi-scale data fitting, and impacts of dynamic host immunity from an individual to the whole population. We apply the models to vector-borne diseases, such as Rift Valley fever (RVF) and dengue (DENV), with immunological and epidemiological data. Using invasion dynamics analysis and multi-scale numerical methods, we characterize different scenarios of virus-host evolution and coexistence of viral strains under waning host cross-immunity. In the case of DENV, we recapitulate how intermediate levels of pre-existent antibodies enhance infection within a host, and how to scale up to distributions of antibody levels among epidemiological classes in the host population to determine risk of severe DENV prevalence. These results have implications for optimal vaccination policy, and the modeling framework developed here is currently being applied to examine the emergence of COVID-19 variants partially resistant to antibodies induced by host infection or vaccination.
Mini-Seminar�Mathematics and the renewed quest for malaria eradication
Abba B Gumel�Arizona State University,
The widespread use of insecticide-based interventions against malaria mosquitoes over the last two decades has led to a dramatic reduction in global malaria burden, prompting a renewed quest to eradicate the disease by 2030 or 2040. Unfortunately, such heavy use of insecticides has also resulted in widespread resistance (in the malaria vector population) to all the currently available insecticides used in vector control. In this lecture, I will briefly present a genetics-epidemiology modeling framework for assessing the impacts of insecticide resistance and climate change on malaria transmission dynamics, with emphasis on determining whether the malaria eradication objective can be achieved using existing vector control resources.
Requests for Input/Suggestions
We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present
Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite
Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively
There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions
Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues
fini