1 of 22

Assessment of the Correlation of Medication Beliefs With Time to COVID-19 Vaccination

Presenters: Tatum Cravens, Nancy Dang, Shifa Haquani

​

Mentors: John Billimek, PhD and Andrew Vu

2 of 22

Introduction

01

Methodology

02

Results Analysis

03

Conclusions

04

TABLE OF CONTENTS

Relationship between medication beliefs and time to COVID-19 vaccination

Unadjusted survival analysis was used to look at medication beliefs

3 of 22

Why this is important?

4 of 22

5 of 22

6 of 22

Past research

Past studies have shown that there is a correlation between medication avoidance and influenza vaccine hesitancy (Sagor and AlAteeq 2018)

7 of 22

Objectives

Research Question

Hypothesis

How does medication belief correlate to the time to COVID-19 vaccination?

We predict that those with negative medication beliefs are more likely to have a longer time to COVID-19 vaccine dose than those with positive beliefs

8 of 22

How were data collected?

Sample population: 283 patients at UCI Family Health Center in Santa Ana, CA

  • 18+ years old
  • Primarily Spanish-speaking Latinx
  • Uncontrolled hypertension

Data collection:

  • Beliefs about Medication Questionnaire (BMQ)
  • Patient Health Records via EPIC EMR system

​

9 of 22

Measure of medication beliefs

  • Necessity vs. Concern
  • Independent variable: Net medication beliefs score
    • Three groups:
      • Negative medication belief

Necessity < Concern

      • Neutral medication belief

Necessity = Concern

      • Positive medication belief

Necessity > Concern

10 of 22

Measures cont.

  • Dependent variable:

Time to event (# of days to vaccination)

    • 1st dose
    • 2nd dose
    • Booster dose

​

​

​

* Day 0 for 1st dose: 12/14/2020

​

11 of 22

Data analysis

Statistical method:

  • Unadjusted survival analysis on different medication belief groups and time to vaccination per dose (first, second, and booster)
    • Kaplan-Meier test
  • Determined median number of days to first, second, and booster vaccine dose

​

12 of 22

Demographics

F

M

Place of Birth

86.3% were born outside of the US

Education Stats

78.2% have less than a high school education

Sample (n=283)

192

67.6%

90

31.7%

Income Data

Below $20,000

Above $20,000

Did not Report

Age range: 25-85

Age range: 30-84

52.5%

23.2%

24.3%

Mean (SD) age = 58 (10)

13 of 22

First dose

​

Overall median time:

106 days (~3 months)

​

Median times by beliefs:

  • Positive: 98 days
  • Neutral: 106 days
  • Negative: 115 days

​

​

14 of 22

Second dose

​

Overall median time:

28 days (~1 month)

​

Median times by beliefs:

  • Positive: 28 days
  • Neutral: 28 days
  • Negative: 28 days

15 of 22

Booster dose

​

Overall median time:

243 days (~8 months)

​

Median times by beliefs:

  • Positive: 236 days
  • Neutral: 246 days
  • Negative: 235 days

​

16 of 22

No statistical significance was found in the time to vaccination between patients with positive, neutral, and negative beliefs about medication

17 of 22

  • Vaccine rollout strategy could be catered to negative medication beliefs
  • We can expect more confidence in people receiving their follow-up doses (second, booster, etc.) if they get the first dose

Most important step to full vaccination: Getting started on first dose

18 of 22

Future Research

  • Analyze different measures of medication beliefs and adjust models of co-variables that may affect these populations
    • I.e. age, sex, smoking status, alcohol status
  • Expand sample population to include other clinics and represent other patient conditions

19 of 22

Thank you!

Do you have any questions?

Special Acknowledgements:

HELIOS Lab and PI, Dr. John Billimek, PhD

Project Coordinator, Jacqueline Chow

Quantitative Analyst, Andrew Vu

Department of Family Medicine

Department of Biostatistics and Epidemiology

UCI UROP

Check out other HELIOS student presentations

Learn more about HELIOS lab

CREDITS: This presentation template was created by Slidesgo, and it includes icons by Flaticon, infographics & images by Freepik

20 of 22

Sample BMQ Questions

21 of 22

Filtering process for participant data

  • Initial total of 370 patients administered BMQs within Mi Propio Camino study
  • 233 patients remaining after elimination of vaccine data past end of May/early June 2021
    • Last vaccination date: 05/19/2021
  • Data collection: double coded to ensure data fidelity

22 of 22

Timeline of a Median Participant

Not vaccinated

1st dose

106 days

​

~3 months

Booster

Release Date:

11/19/2021

​

Day of first dose release

12/14/2020

2nd Dose

01

02

03

04

05

28 days

​

~1 month

243 days

​

~8 months