Lomefloxacin

Jinel Go, Lane Gregg, Michelle Nham, Simone June Bagalso

Photo from: Sigma- Aldrich

http://www.sigmaaldrich.com/catalog/product/sigma/l2906?lang=en&region=US

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What is your antibiotic and how was it discovered?

• Lomefloxacin is an antibiotic known as a fluoroquinolone.
• Fluoroquinolones are broad spectrum antibacterial drugs
• It was discovered by accident in 1962 when scientists were working on a derivative of it, nalidixic acid.

What types of bacteria or conditions is the antibiotic used to treat?

• Lomefloxacin works on both gram-negative and gram-positive bacteria

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Gram-negative Gram-positive

• This antibiotic is widely used in treating UTI’s, bronchitis, and prevention of infections during surgeries.

Pictures from: Food Poison Journal and nd Online Textbook of Bacteriology

http://www.foodpoisonjournal.com/food-poisoning-information/everything-you-wanted-to-know-about-e-coli-but-really-didnt/#.U2ldutKsim4

http://textbookofbacteriology.net/Anthrax.html

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What is the range of effective doses for E.Coli?

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• Effective: 20mL at concentration 10ug/ml

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• Working: 10mL at concentration 5ug/ml

How is it delivered to the host?

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• Lomefloxacin is generally found in pill for and taken orally
• This antibiotic has a 95% - 98% rate of absorption with each oral dose.
• 1997 Hoogkamp-Korstanje study

How does the antibiotic work?

• Lomefloxacin inhibits DNA synthesis by interfering with DNA-gyrase and topoisomerase 4, which play roles in transcription and replication.

How does it reach the pathogen?

• Once the Lomefloxacin has been absorbed through the the upper portion of the small intestine, it makes its way into the blood where it can flow through the body to infected areas.

What does it do to kill or slow the production of the pathogen?

• Lomefloxacin stops the production of the pathogen by inhibiting replication and transcription.

Are any pathogens resistant to this drug?

• The pathogens that are resistant to Lomefloxacin depends on the organisms itself.

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• Pathogens have different characteristics and origin of strains

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• Staphylococcus aureus

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Results/Discussion

• Did our results support our hypothesis?

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• Why/why not?

References

• http://cid.oxfordjournals.org/content/24/Supplement_1/S67.full.pdf+html

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• http://aac.asm.org/content/34/6/1088.full.pdf+html�
• http://jac.oxfordjournals.org/content/40/3/427.full.pdf

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• http://www.drugbank.ca/drugs/DB00978

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