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Highlights of ASCO 2025

Videocast SBM-SP

Dr. Lincon Jo Mori

Coordenador da Comissão de Educação Continuada │SBM-SP

Dr. Leonardo Orlandini

Comissão de Educação Continuada │SBM-SP

Dr. Carlos Barrios

Presidente do LACOG e Coordenador de Pesquisa Hospital São Lucas │ PUC-RS

Dr. Franklin Pimentel

Coordenador da Comissão de Tratamento Sistêmico da SBM-SP

Dr. Ruffo de Freitas

Professor Associado Universidade Federal de Goias

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Tópicos

  1. Oasis-4 trial – Cardoso F et al.
  2. Poster / Local Estrogen Therapy Among BC Patients, SEER-MHOS – Mitchel O et al.
  3. NeoCARHP trial – Wang K et al.
  4. Destiny – Breast 09 – Tolaney SM et al.
  5. Serena-6 trial – Turner N et al.
  6. Ascent-04 / Keynote-D19 study – Tolaney SM al.
  7. Inavo 120 – Turner N et al.

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<br />Efficacy and safety of elinzanetant for vasomotor symptoms associated with endocrine therapy: Phase III OASIS-4 trial

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Key takeaway points

Cardoso F ASCO 2025

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Results – Mean change from baseline in average daily moderate-to-severe VMS frequency over time

Cardoso F ASCO 2025

Cardoso F ASCO 2025

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Conclusions

Cardoso F ASCO 2025

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Slide 17

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What this study means for patients

Cardoso F ASCO 2025

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Agrawal L ASCO 2025

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Agrawal L ASCO 2025

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Agrawal L ASCO 2025

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De-escalated neoadjuvant taxane plus trastuzumab and pertuzumab with or without carboplatin in HER2-positive early breast cancer (neoCARHP): A multicentre, open-label, randomised, phase 3 trial

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Background

Wang K ASCO 2025

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neoCARHP Study Design (NCT04858529)

Wang K L ASCO 2025

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Baseline Patients Characteristics

Wang K ASCO 2025

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Efficacy Analysis: pCR

Wang K L ASCO 2025

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Efficacy Analysis: pCR by hormone receptor status

Wang K ASCO 2025

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Efficacy Analysis: pCR by Subgroup

Wang K ASCO 2025

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Clinical response during neoadjuvant therapy

Wang K ASCO 2025

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Grade ≥ 3 hematological adverse events

Wang K ASCO 2025

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Frequent non-hematological adverse events

Wang K ASCO 2025

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Conclusions

Wang K ASCO 2025

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Trastuzumab deruxtecan (T-DXd) + pertuzumab vs taxane <br />+ trastuzumab + pertuzumab (THP) for first-line treatment <br />of patients with human epidermal growth factor <br />receptor 2–positive (HER2+) advanced/metastatic<br />breast cancer: interim results from DESTINY-Breast09

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Key takeaways

Tolaney SM ASCO 2025

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Evolution of T-DXd in HER2+ a/mBC

Tolaney SM ASCO 2025

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DESTINY-Breast09 study design

Tolaney SM ASCO 2025

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Patient demographics and key baseline characteristics

Tolaney SM ASCO 2025

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Prior therapies

Tolaney SM ASCO 2025

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PFS (BICR): primary endpoint

Tolaney SM ASCO 2025

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PFS (investigator assessment)

Tolaney SM ASCO 2025

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PFS (BICR): subgroup analyses

Tolaney SM ASCO 2025

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ORR and DOR (BICR)

Tolaney SM ASCO 2025

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Overall survival (~16% maturity)

Tolaney SM ASCO 2025

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PFS2 (investigator assessment) and post-trial treatments

Tolaney SM ASCO 2025

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Overall safety summary

Tolaney SM ASCO 2025

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Conclusions

Tolaney SM ASCO 2025

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First Line Therapy for HER2+ MBC:<br />A New Treatment Paradigm?

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Key Takeaway Points – Destiny Breast09 Trial

Isaacs C ASCO 2025

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1L HR+/HER2+ mBC: PATINA Trial

Isaacs C ASCO 2025

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1L HER2+ Metastatic Breast Cancer: CLEOPATRA<br />End-of-Study Analysis

Isaacs C ASCO 2025

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DESTINY-Breast09 – 1L HER2+ mBC

Isaacs C ASCO 2025

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DESTINY-Breast09 – 1L HER2+ mBC

Isaacs C ASCO 2025

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DB-09: Toxicity

Isaacs C ASCO 2025

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Slide 9

Isaacs C ASCO 2025

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Sequencing- T-DXd First Line or Second Line?<br />PFS2 Data from DB-09

Isaacs C ASCO 2025

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How do we integrate these data in our treatment algorithm?

Isaacs C ASCO 2025

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How Do We Best Sequence HER2 Directed Therapy?

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How Do We Best Sequence HER2 Directed Therapy?<br />Markers of response

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How Do We Best Sequence HER2 Directed Therapy?

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Duration of Therapy with T-DXd

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Summary:

Isaacs C ASCO 2025

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Camizestrant + CDK4/6 inhibitor for the treatment of emergent ESR1 mutations during first-line endocrine-based therapy and ahead of disease progression in patients with HR+/HER2– advanced breast cancer: <br />Phase 3, double-blind ctDNA-guided SERENA-6 trial

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Background

Turner N ASCO 2025

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Background to the SERENA-6 study

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ESR1m surveillance during first-line AI+CDK4/6i

Turner N ASCO 2025

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SERENA-6 study design

Turner N ASCO 2025

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Baseline characteristics

Turner N ASCO 2025

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Primary endpoint: Investigator-assessed PFS

Turner N ASCO 2025

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Investigator-assessed PFS by subgroup

Turner N ASCO 2025

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Time to deterioration in global health status/quality of life<br />EORTC QLQ-C30

Turner N ASCO 2025

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Second progression-free survival (PFS2)<br />Key secondary endpoint

Turner N ASCO 2025

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Safety summary

Turner N ASCO 2025

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Adverse events (≥10% of patients)

Turner N ASCO 2025

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Conclusions

Turner N ASCO 2025

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Acknowledgments

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Attacking resistance at its earliest sign:<br /> Can we improve outcomes in ER+ metastatic breast cancer?

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Key Take Aways: SERENA-6

DeMichele A ASCO 2025

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PFS for SERDS in 2nd line ESR1m ER+ MBC

DeMichele A ASCO 2025

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SERENA-6 hypotheses and rationale

DeMichele A ASCO 2025

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SERENA-6 met primary endpoint

DeMichele A ASCO 2025

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SERENA-6: Study Strengths

DeMichele A ASCO 2025

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SERENA-6 PFS: Unanswered questions

DeMichele A ASCO 2025

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Defining “Clinical Utility”

DeMichele A ASCO 2025

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Overall survival and PFS-2

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PFS-2 in SERENA-6

DeMichele A ASCO 2025

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Other issues that could impede determination of clinical utility

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Lack of crossover limits clinical utility assessment

DeMichele A ASCO 2025

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Imbalance in post-progression treatment

DeMichele A ASCO 2025

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Slide 18

DeMichele A ASCO 2025

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Serial ctDNA screening for mutations is a big lift

DeMichele A ASCO 2025

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QOL and costs during testing phase

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Key Take Aways from SERENA-6

DeMichele A ASCO 2025

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How to counsel patient ?

DeMichele A ASCO 2025

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Sacituzumab Govitecan Plus Pembrolizumab vs Chemotherapy Plus Pembrolizumab in Patients With Previously Untreated, <br />PD-L1 Positive, Advanced or Metastatic Triple-Negative Breast Cancer: Primary Results From the Randomized, Phase 3 ASCENT-04/KEYNOTE-D19 Study

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Key Takeaways: ASCENT-04/KEYNOTE-D19 Phase 3 Study

Tolaney SM ASCO 2025

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Unmet Need in Previously Untreated, PD-L1+, Locally Advanced Unresectable or Metastatic TNBC

Tolaney SM ASCO 2025

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ASCENT-04/KEYNOTE-D19 Study Design

Tolaney SM ASCO 2025

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Statistical Analysis

Tolaney SM ASCO 2025

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Demographics and Baseline Characteristics

Tolaney SM ASCO 2025

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Progression-Free Survival by BICR

Tolaney SM ASCO 2025

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Progression-Free Survival by Investigator Assessment

Tolaney SM ASCO 2025

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Subgroup Analysis of Progression-Free Survival by BICR

Tolaney SM ASCO 2025

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Slide 10

Tolaney SM ASCO 2025

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Tumor Responses and Duration of Response by BICR

Tolaney SM ASCO 2025

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Exposure and Safety Summary

Tolaney SM ASCO 2025

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Most Common Adverse Events (≥20% in any group)

Tolaney SM ASCO 2025

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Adverse Events of Special Interest

Tolaney SM ASCO 2025

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Conclusions

Tolaney SM ASCO 2025

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INAVO120 Phase III trial final overall survival (OS) analysis of first-line inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + <br />fulvestrant (FULV) in patients (pts) with PIK3CA-mutated, <br />hormone receptor-positive (HR+), HER2-negative (HER2–), <br />endocrine-resistant advanced breast cancer (aBC).

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Key takeaway points/conclusions

Turner N ASCO 2025

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Background

Turner N ASCO 2025

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INAVO120: A Phase III, randomized, double-blind, <br />placebo-controlled study1,2

Turner N ASCO 2025

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INAVO120 primary analysis results

Turner N ASCO 2025

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INAVO120 updated patient disposition

Turner N ASCO 2025

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INAVO120 updated PFS

Turner N ASCO 2025

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INAVO120 key secondary endpoint: OS

Turner N ASCO 2025

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INAVO120 OS in key subgroups (1/2)

Turner N ASCO 2025

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INAVO120 OS in key subgroups (2/2)

Turner N ASCO 2025

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INAVO120 key post-progression therapies

Turner N ASCO 2025

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INAVO120 other key secondary endpoints

Turner N ASCO 2025

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INAVO120 time to first subsequent chemotherapy

Turner N ASCO 2025

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INAVO120 overview of AEs

Turner N ASCO 2025

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INAVO120 selected AEs*

Turner N ASCO 2025

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INAVO120 limitations

Turner N ASCO 2025

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Key takeaway points/conclusions

Turner N ASCO 2025

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Obrigado !

@sbmastologiasp

@sbmastologiaspcientifico

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