RDA-OfR WG on Managing and Integrating Multiomics Data

Brainstorming Workshops

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Thursday 7 September

08:00-09:00 UTC

16:00-17:00 UTC

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Connie Clare (connie.clare@rda-foundation.org)

A few logistics

• Background: About the Working Group
• How to participate during this workshop:
• 📝 We will take notes in our collaborative Google doc (workshop 1)
• 📹 Discussions recorded for internal use
• 🖐 Raise hand & unmute
• 💬 Add to the chat
• Take a moment to read our guiding principles and how to report a breach at the top of the Google doc.
• Join the RDA: https://www.rd-alliance.org/user/register
• Ask me anything! Connie Clare: connie.clare@rda-foundation.org

A few logistics

• Background: About the Working Group
• How to participate during this workshop:
• 📝 We will take notes in our collaborative Google doc (workshop 2)
• 📹 Discussions recorded for internal use
• 🖐 Raise hand & unmute
• 💬 Add to the chat
• Take a moment to read our guiding principles and how to report a breach at the top of the Google doc.
• Join the RDA: https://www.rd-alliance.org/user/register
• Ask me anything! Connie Clare: connie.clare@rda-foundation.org

RDA-OfR WG on Managing and Integrating Multiomics Data

Brainstorming Workshops

​

Thursday 7 September

08:00-09:00 UTC

16:00-17:00 UTC

​

Connie Clare (connie.clare@rda-foundation.org)

Aim for today

1. To discuss and define the scope of the new RDA-OfR WG�on Managing and Integrating Multiomics Data (title of WG to be confirmed)
2. Capture main points/ideas to draft the Case Statement (deadline Friday 22 September)
3. Identify initial WG co-chairs and members

Add your name to the collaborative notes (page 2)

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Photo by Connor McSheffrey on Unsplash

Today’s agenda

Workshop 1: Welcome to participants 👋🏼

Workshop 2: Welcome to participants 👋🏼

Workshop 2: Welcome to participants 👋🏼

An Overview of the Working Group: Aims and your initial thoughts

Photo by Júnior Ferreira on Unsplash

About the RDA-OfR�Working Group

• Public-private partnership model
• WG facilitated by the RDA (12 months duration)
• Outputs owned by the RDA community
• Powered by Oracle for Research
• Dedicated Technical Advisory Board liaison
• At least 2 international co-chair experts
• WG open to all RDA community members
• Monthly meetings & three-monthly progress review
• Promotion & communication activities
• Outputs & recommendations openly available under CC-BY license

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Photo by Júnior Ferreira on Unsplash

Challenges of managing multi-omics data

Sensitive data, privacy and ethical data sharing

Lack of diverse datasets for human Omics (GWAS)

Lack of ontologies and controlled vocabularies across disciplines to enable synchronous metadata

Lack of clear standards and best practices for data management (formats) and sharing (bioinformatics and in silico)

Lack of integrated / linked repositories

Different methodologies and data formats across disciplines

Data volume (managing, analysing big, complex datasets)

Lack of compute resources

Fragmented standards across Omics disciplines

Lack of / incomplete metadata hindering reproducibility

Lack of awareness, training and capacity-building pipelines

Varying fragmented standards = challenge to integrate across Omics disciplines

Lack of publicly available tools for integrated analysis

Your ideas for the scope of this WG

1. BEST PRACTICES FOR MANAGING MULTIOMICS DATA

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• Engage with stakeholders to co-create recommendations on multiomics data management best practices.
• Identify best practices for managing and sharing data from different -omics disciplines.
• Identify tools and platforms which align with best practices.
• Consult stakeholders, and understand their incentives and barriers to implementing FAIR practices and standards.
• Determine ‘easiest target, low-barrier’ FAIR standards and best practices for managing multiomics data.
• Provide advocacy and training materials for multiomics data standards and best practices for FAIR data generation.
• Collect use cases, supplemented with example data and tutorials/guides for beginners on how to manage multiomics data.
• Create recommendations for how to engage and support researchers and provide training infrastructure.

2. METADATA STANDARDS FOR MULTIOMICS DATA

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• Create a Multi-Omics Metadata Schema Standard reporting template with community representation across domains with use-case examples.
• By leveraging pre-existing domain metadata standards, ontologies, and reporting guidelines this working group could advance current siloed community harmonization efforts with much needed cross-disciplinary diversity for creating more sustainable standard outputs fully representative of various data types and computational formats.
• Understand the different levels of metadata for specific roles while being flexible enough for researchers.
• Important: Leverage existing standards at all possible, and standards best practices…

Your ideas for the scope of this WG

Collecting use cases from various -omics domains and identifying standards/best practices across them to identify metadata standards that could link across -omics domains –

leading to the deliverable of a metadata schema standard reporting template

Time for discussion!�Head to the Google doc

• Register your interest to join the WG by adding a tick (✔️) in the Google doc
• Co-chairs may undergo selection to encourage diversity
• Please review, draft and edit the Case Statement by Friday 22 September
• Note: Co-chairs will be involved in drafting sections of the case statement

Next steps

• Friday 22 September - Workshop participants review and edit case statement
• Monday 2 October- Publication of case statement for review
• 28 October - Endorsement of case statement by community, TAB and Council
• November - Monthly meeting
• December - Monthly meeting
• January - Monthly meeting & three-month review
• February - Monthly meeting
• March - Monthly meeting
• April - Monthly meeting & three-month review

Photo by Gio Bartlett on Unsplash

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