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Enzymes

Giving cells control �of all their chemical reactions

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Counter Top

Outside

Human Body

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Counter Top

Outside

Human Body

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Counter Top

Outside

Human Body

in days / weeks

in months / years

in hours

partially decomposed

(mouldy)

fully decomposed�(compost)

broken down into smaller nutrients and absorbed into blood

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Counter Top

Outside

Human Body

in days / weeks

in months / years

in hours

partially decomposed

(mouldy)

fully decomposed�(compost)

broken down into smaller nutrients and absorbed into blood

WHY THE DIFFERENCE?

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Why The Difference?

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Why The Difference?

Enzymes are highly specialized molecular tools that make extremely specific chemical reactions take place as a result of their 3D shape

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

matter tends to lose energy and remain in its lowest stable energy state.

Why does this exist in nature

?

AB

A

B

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

EA

To make or break bonds requires some energy INPUT.

This is called

ACTIVATION ENERGY (EA )

A

B

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

EA

All reactions require activation energy to proceed. Even the endothermic reaction shown below

A

B

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

A

B

Transition State

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The Progress of a Chemical Reaction

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

A

B

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

EA

The presence of an enzyme �LOWERS THE ACTIVATION ENERGY required for the reaction to proceed

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

no enzyme

with enzyme

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

A

B

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The Progress of a Chemical Reaction�WITHOUT AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

ambient energy at body temperature

AB

No reaction

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

A

B

ambient energy at body temperature

Reaction is spontaneous and goes to completion

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The Progress of a Chemical Reaction�WITH AN ENZYME

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

AB

A

B

… but HOW does an enzyme lower the activation energy?

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Important Terminology

A

B

A

B

Reactants

Products

Enzyme(s)

Substrates

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Important Terminology

A

B

Reactants

Substrates

Enzyme

amino acid

protein

a protein that facilitates �a chemical reaction

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Important Terminology

A

B

A

B

Enzyme

a protein that facilitates �a chemical reaction

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Important Terminology

A

B

Enzyme-Substrate Complex

the location on the enzyme where the substrate binds

active site

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The Induced Fit Model

A

B

The 3D conformational change of the enzyme-substrate complex is what causes a reaction to occur.

A

B

Enzyme-Substrate Complex

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The Induced Fit Model

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The Induced Fit Model

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3D Shape

A

B

Notice that when the ES complex forms, �the 3D shape of the active site orients the substrate(s) in a very specific arrangement

forms ONLY this specific bond

A

B

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3D Shape

A

B

This can encourage the �formation of a specific new bond.

forms ONLY this specific bond

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3D Shape

A

B

The 3D conformational change can �stress existing bonds and break them.

A

B

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R-Groups in the Active Site

Product

Substrate

The R-groups of the amino acids in the active site can interact with the substrate in ways that encourage or weaken chemical bonds.

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R-Groups in the Active Site

Though R-groups can be involved in the reaction, �they are not chemically altered.

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Summary: How Does an Enzyme Lower Activation Energy?

AB

Progress of Reaction / Time

Energy

Reactant(s)

Product(s)

no enzyme

with enzyme

A

B

  1. Line-up substrates encouraging the formation of specific new bonds�
  2. Flex and stress existing bonds to encourage them to break�
  3. Interactions with R-groups in the active site favour the rearrangement of bonds.

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Enzymes are REUSABLE�(i.e. not used up in the reaction)

A

B

Product(s) have new chemical and physical properties and a new 3D shape, so they no longer bind to the active site.�When product(s) exit, the enzyme returns to its original conformation and can be reused

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Enzyme Cycle

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Summary: What Do Enzymes Do?

Lower activation energy (EA)

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Summary: What Do Enzymes Do?

Make reactions spontaneous.

(i.e. make reactions possible that otherwise would not happen)

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Summary: What Do Enzymes Do?

Make reactions highly specific

A

B

A

B

Enzyme

NOT….

A

B

A

B

A

A

A

A

B

A

B

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Summary: What Do Enzymes Do?

Make reactions occur rapidly and to completion�since enzyme molecules are reusable

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Loss of Enzyme Activity�(denaturation)

  • Recall: All proteins (including enzymes) are sensitive to changes in temperature and pH

Primarily through the disruption of hydrogen bonds, complete or partial unfolding of an enzyme alters the 3D shape of the active site.

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Loss of Enzyme Activity�(denaturation)

low kinetic energy

enzyme rigidity

Temperature

Enzyme Activity

(reaction rate)

denaturation

optimum

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Loss of Enzyme Activity�(denaturation)

denaturation

pH

Enzyme Activity

(reaction rate)

denaturation

optimum

acidic

basic

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Loss of Enzyme Activity�(denaturation)

pH

Enzyme Activity

(reaction rate)

denaturation

optimum

acidic

basic

denaturation

more sensitive to acid

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Loss of Enzyme Activity�(denaturation)

denaturation

pH

Enzyme Activity

(reaction rate)

optimum

acidic

basic

denaturation

more sensitive to base

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Enzyme Inhibition and Activation

Some enzymes can be�turned on and off

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Competitive Inhibition

i

i

A

B

A molecule other than the substrate binds or partially binds to the active site. This blocks access to the active site for any other molecule.

competitive inhibitor

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Competitive Inhibition

i

i

A

B

The presence of the competitive inhibitor �turns the enzyme OFF.

competitive inhibitor

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Non-Competitive Inhibition

active site

allosteric site

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Non-Competitive Inhibition

A

B

A

B

When nothing is bound to the allosteric site, the active site is receptive to substrate. The enzyme is ON.

* induced fit not shown for simplicity

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Non-Competitive Inhibition

i

i

non-competitive (allosteric) inhibitor

If a molecule binds to the allosteric site �the enzyme will change its 3D shape.

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Non-Competitive Inhibition

i

A

B

When a non-competitive inhibitor is bound to the allosteric site, the active site is no longer receptive to substrate. �The enzyme is OFF.

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Enzyme Activation

A

B

For some enzymes the allosteric site �can be used to turn it ON.

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Enzyme Activation

a

a

When an activator is bound to the allosteric site, the enzyme becomes receptive to the enzyme.

activator

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Enzyme Activation

a

The enzyme is only ON when the activator is bound.

A

B

A

B

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Enzyme Activation

When a coenzyme binds to the active site it turns the enzyme on by giving it the correct 3D shape

apoenzyme

holoenzyme

coenzyme

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Enzyme Activation

If the activator molecule bound to the active site �is not made of protein it is called a cofactor.

holoenzyme

cofactor

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Summary of Inhibition

ON

OFF

competitive

non-competitive

i

i

i

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Summary of Activation

ON

OFF

allosteric

Cofactors / coenzymes

a

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THE END

(or is it just the beginning)