1 of 21

Trastuzumab deruxtecan (T-DXd) <br />vs treatment of physician’s choice in patients with <br />HER2-low unresectable and/or metastatic breast cancer: <br /> <br />Results of DESTINY-Breast04, a randomized, phase 3 study

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

2 of 21

DESTINY-Breast04 Summary and Impact

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

3 of 21

HER2-low mBC: Unmet Clinical Need

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

4 of 21

Slide 4

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

5 of 21

Slide 5

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

6 of 21

Slide 6

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

7 of 21

Slide 7

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

8 of 21

Slide 8

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

9 of 21

Slide 9

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

10 of 21

Slide 10

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

11 of 21

Slide 11

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

12 of 21

Slide 12

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

13 of 21

Slide 13

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

14 of 21

Slide 14

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

15 of 21

Slide 15

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

16 of 21

Slide 16

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

17 of 21

Slide 17

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

18 of 21

Slide 18

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

19 of 21

Slide 19

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

20 of 21

Slide 20

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.

21 of 21

Slide 21

Content of this presentation is the property of the author, licensed by ASCO. Permission required for reuse.