IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars
March 10, 2022
Welcome - The meeting will start at 3PM ET
NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND
Agenda
People
Co-Lead: Reinhard Laubenbacher, PhD
Department of Medicine
Laboratory for Systems Medicine
University of Florida
reinhard.laubenbacher@medicine.ufl.edu
Co-Lead: James A. Glazier, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Web Administration, Slack: James P. Sluka, PhD
Dept. of Intelligent Systems Engineering and Biocomplexity Institute
Indiana University, Bloomington
Activities Coordination: Lorenzo Veschini, PhD
King’s College London
Slack Channel
https://Msm-working-group.slack.com
Our IMAG/MSM Wiki page
https://www.imagwiki.nibib.nih.gov/working-groups/multiscale-modeling-and-viral-pandemics Feel free to suggest additional content!
Or, use the Tiny URL: https://tinyurl.com/hkr97vfe
IMAG’s LinkedIn
YouTube “MSM Working Group on Multiscale Modeling” https://www.youtube.com/channel/UCuDFvhgFziRRDcpRnT3vlrw �see also the links on our seminar page at https://tinyurl.com/5fra7jjd
Please follow the�group on Twitter!
If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.
Announcements
�Any short (~1 minute) items such as;
Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility. Karr J, Malik-Sheriff RS, Osborne J, Gonzalez-Parra G, Forgoston E, Bowness R, Liu Y, Thompson R, Garira W, Barhak J, Rice J, Torres M, Dobrovolny HM, Tang T, Waites W, Glazier JA, Faeder JR and Kulesza A (2022) Front. Syst. Biol. 2:822606. doi: 10.3389/fsysb.2022.822606 https://www.frontiersin.org/articles/10.3389/fsysb.2022.822606/full
Schedule for Upcoming Meetings and mini-Seminars
March 17:
March 24:
March 31:
April 7:
Request for future speakers (March 24, 31, …)
Rules of the Meeting
Please mute your microphone and hold questions until after the presentations
Mini-Seminar�From your nose to your toes: SARS-CoV-2-mediated systemic inflammation in the absence of viremia
Benjamin tenOever�New York University
Virus infections can result in inflammation that far exceeds the pathogen’s natural tropism as evident by the heterogeneity of diseases that cause mortality following SARS-CoV-2 infection. To understand this dynamic, we characterized the systemic longitudinal response to SARS-CoV-2 in the golden hamster. We find that while infectious virus is largely restricted to the airways, a strong inflammatory response is evident in the lung, olfactory bulb, kidney, spleen, liver, pancreas, heart, lung, intestines, and most areas of the brain. While no viremia could be detected, profiling circulating immune cells indicate that distal immune priming is a product of circulating “viral debris’. We postulate that the magnitude and duration of this host response to SARS-CoV-2 reflects the unique life cycles of this virus family. The lecture will end with some suggestions where modeling may address some of the remaining unknowns as it relates to COVID-19 biology.
Requests for Input/Suggestions
We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present
Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite
Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively
There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions
Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues
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