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Lesson Overview

11.1 The Work of

Gregor Mendel

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THINK ABOUT IT

What is an inheritance?

It is something we each receive from our parents—a contribution that determines our blood type, the color of our hair, and so much more.

What kind of inheritance makes a person’s face round or hair curly?

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The Experiments of Gregor Mendel

Where does an organism get its unique characteristics?

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The Experiments of Gregor Mendel

Where does an organism get its unique characteristics?
An individual’s characteristics are determined by factors that are passed from one parental generation to the next.

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The Experiments of Gregor Mendel

Every living thing—plant or animal, microbe or human being—has a set of characteristics inherited from its parent or parents.
The delivery of characteristics from parent to offspring is called heredity.
The scientific study of heredity, known as genetics, is the key to understanding what makes each organism unique.

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The Experiments of Gregor Mendel

The modern science of genetics was founded by an Austrian monk named Gregor Mendel.
Mendel was in charge of the monastery garden, where he was able to do the work that changed biology forever.

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The Experiments of Gregor Mendel

Mendel carried out his work with ordinary garden peas, partly because peas are small and easy to grow. A single pea plant can produce hundreds of offspring.
Today we call peas a “model system.”

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The Experiments of Gregor Mendel

Scientists use model systems because they are convenient to study and may tell us how other organisms, including humans, actually function.

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The Experiments of Gregor Mendel

By using peas, Mendel was able to carry out, in just one or two growing seasons, experiments that would have been impossible to do with humans and that would have taken decades—if not centuries—to do with other large animals.

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The Role of Fertilization

Mendel knew that the male part of each flower makes pollen, which contains sperm—the plant’s male reproductive cells.

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The Role of Fertilization

Similarly, Mendel knew that the female portion of each flower produces reproductive cells called eggs.

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The Role of Fertilization

During sexual reproduction, male and female reproductive cells join in a process known as fertilization to produce a new cell.
In peas, this new cell develops into a tiny embryo encased within a seed.

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The Role of Fertilization

Pea flowers are normally self-pollinating, which means that sperm cells fertilize egg cells from within the same flower.
A plant grown from a seed produced by self-pollination inherits all of its characteristics from the single plant that bore it. In effect, it has a single parent.

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The Role of Fertilization

Mendel’s garden had several stocks of pea plants that were “true-breeding,” meaning that they were self-pollinating, and would produce offspring with identical traits to themselves.
In other words, the traits of each successive generation would be the same.
A trait is a specific characteristic of an individual, such as seed color or plant height, and may vary from one individual to another.

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The Role of Fertilization

Mendel decided to “cross” his stocks of true-breeding plants—he caused one plant to reproduce with another plant.

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The Role of Fertilization

To do this, he had to prevent self-pollination. He did so by cutting away the pollen-bearing male parts of a flower and then dusting the pollen from a different plant onto the female part of that flower, as shown in the figure.

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The Role of Fertilization

This process, known as cross-pollination, produces a plant that has two different parents.
Cross-pollination allowed Mendel to breed plants with traits different from those of their parents and then study the results.

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The Role of Fertilization

Mendel studied seven different traits of pea plants, each of which had two contrasting characteristics, such as green seed color or yellow seed color.
Mendel crossed plants with each of the seven contrasting characteristics and then studied their offspring.
The offspring of crosses between parents with different traits are called hybrids.

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Genes and Alleles

When doing genetic crosses, we call the original pair of plants the P, or parental, generation.

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Genes and Alleles

Their offspring are called the F₁, or “first filial,” generation.

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Genes and Alleles

For each trait studied in Mendel’s experiments, all the offspring had the characteristics of only one of their parents, as shown in the table.

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Genes and Alleles

In each cross, the nature of the other parent, with regard to each trait, seemed to have disappeared.

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Genes and Alleles

From these results, Mendel drew two conclusions. His first conclusion formed the basis of our current understanding of inheritance.
An individual’s characteristics are determined by factors that are passed from one parental generation to the next.
Scientists call the factors that are passed from parent to offspring genes.

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Genes and Alleles

Each of the traits Mendel studied was controlled by one gene that occurred in two contrasting varieties.
These gene variations produced different expressions, or forms, of each trait.
The different forms of a gene are called alleles.

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Dominant and Recessive Traits

Mendel’s second conclusion is called the principle of dominance. This principle states that some alleles are dominant and others are recessive.
An organism with at least one dominant allele for a particular form of a trait will exhibit that form of the trait.
An organism with a recessive allele for a particular form of a trait will exhibit that form only when the dominant allele for the trait is not present.

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Dominant and Recessive Traits

In Mendel’s experiments, the allele for tall plants was dominant and the allele for short plants was recessive.

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Dominant and Recessive Traits

In Mendel’s experiments, the allele for tall plants was dominant and the allele for short plants was recessive. Likewise, the allele for yellow seeds was dominant over the recessive allele for green seeds

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Segregation

How are different forms of a gene distributed to offspring?

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Segregation

How are different forms of a gene distributed to offspring?
During gamete formation, the alleles for each gene segregate from each other, so that each gamete carries only one allele for each gene.

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Segregation

Mendel wanted to find out what had happened to the recessive alleles.
To find out, Mendel allowed all seven kinds of F₁ hybrids to self-pollinate. The offspring of an F₁ cross are called the F₂ generation.
The F₂ offspring of Mendel’s experiment are shown.

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The F1 Cross

When Mendel compared the F₂ plants, he discovered the traits controlled by the recessive alleles reappeared in the second generation.
Roughly one fourth of the F₂ plants showed the trait controlled by the recessive allele.

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Explaining the F₁ Cross

Mendel assumed that a dominant allele had masked the corresponding recessive allele in the F₁ generation.
The reappearance of the recessive trait in the F₂ generation indicated that, at some point, the allele for shortness had separated from the allele for tallness.

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Explaining the F1 Cross

How did this separation, or segregation, of alleles occur?
Mendel suggested that the alleles for tallness and shortness in the F₁ plants must have segregated from each other during the formation of the sex cells, or gametes.

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Let’s assume that each F₁ plant—all of which were tall—inherited an allele for tallness from its tall parent and an allele for shortness from its short parent.

The Formation of Gametes

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�The Formation of Gametes

When each parent, or F₁ adult, produces gametes, the alleles for each gene segregate from one another, so that each gamete carries only one allele for each gene.

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�The Formation of Gametes

A capital letter represents a dominant allele. A lowercase letter represents a recessive allele.
Each F₁ plant in Mendel’s cross produced two kinds of gametes—those with the allele for tallness (T) and those with the allele for shortness (t).

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The Formation of Gametes

Whenever each of two gametes carried the t allele and then paired with the other gamete to produce an F₂ plant, that plant was short.
Every time one or more gametes carried the T allele and paired together, they produced a tall plant.
The F₂ generation had new combinations of alleles.