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VIGIL�

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UIPATH AGENTHACK 2026 · TRACK 1 — MAESTRO CASE

VIGIL

Pharmacovigilance adverse-event case orchestration on UiPath Maestro.

Five agents. One human gate. Zero missed deadlines.

Built by: Kingsley Ojilere · github.com/0xkinno/vigil

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VIGIL

THE CHALLENGE

Problem statement and proposed solution

PROBLEM

  • Deadlines run invisible. Serious adverse events carry a 7- or 15-day legal reporting window under ICH E2D — tracked by hand, so nothing warns the team until the window is already gone.
  • Seriousness is decided too late. A case enters as routine and is reclassified serious mid-review, while a linear process keeps moving it at routine speed against an urgent deadline.
  • Accountability is diffuse. A regulatory submission needs a qualified medical sign-off, yet email workflows reconstruct who approved what after the fact, with no enforced gate.

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Problem statement and proposed solution

Problem

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  • Deadlines run invisible. Serious adverse events carry a 7- or 15-day legal reporting window under ICH E2D — tracked by hand, so nothing warns the team until the window is already gone.
  • Seriousness is decided too late. A case enters as routine and is reclassified serious mid-review, while a linear process keeps moving it at routine speed against an urgent deadline.
  • Accountability is diffuse. A regulatory submission needs a qualified medical sign-off, yet email workflows reconstruct who approved what after the fact, with no enforced gate.

SOLUTION

VIGIL makes each of these a governed property of the case, not a reminder, but architecture.

  • A long-running case carries the 15-day regulatory clock end to end.
  • A mandatory human gate blocks closure without a physician's decision.
  • An interrupting exception path fires the instant a case turns serious.
  • A coded causality service feeds the seriousness score that drives routing.

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Benefits and technologies used

End-user​

�Pharmacovigilance officers, medical reviewers (physicians), regulatory affairs

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User department​

Drug Safety / Pharmacovigilance, Regulatory Affairs, Medical

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Industries​

Pharmaceutical, Biotech, Life Sciences, CROs

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UiPath products used​

Maestro (Case), Agent Builder, Action Center, Orchestrator, UiPath for Coding Agents

Other - integrations / APIs / technologies used​

Python causality service (WHO-UMC + ICH E2B / E2D), Gemini coding agent via Antigravity, uip CLI

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Benefits, impact and outcomes

  • 15-day regulatory clock enforced by architecture; warns at 80%, escalates on breach.
  • Mandatory physician sign-off gate - no case closes without accountable medical review.
  • Interrupting exception path auto-escalates a serious case the instant it is flagged.
  • Coded causality service (WHO-UMC + ICH seriousness), self-tested 10 / 10.
  • Every case carries a single, auditable execution trail end to end.

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HOW IT WORKS

Solution architecture

Full architecture, code and run screenshots: github.com/0xkinno/vigil

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SOLUTION ARCHITECTURE

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"See complete architecture and screenshots in our GitHub repository:"

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GitHub Repo: https://github.com/0xkinno/vigil

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VIGIL

WHY VIGIL EXCELS

  • Real, regulated, life-and-death. Pharmacovigilance is a legal duty for every pharma company; a missed deadline is a reportable failure. VIGIL governs that deadline by architecture.
  • Agentic and human-accountable. Five agents do the work autonomously while a physician stays accountable for the high-impact decision — the balance enterprise orchestration demands.
  • Coded and low-code, blended. A coding agent built the causality service that drives the low-code case's routing — the combination AgentHack set out to reward.

Every report a case. Every case on the clock. Every serious patient escalated in time.

VIGIL · UiPath AgentHack 2026 · github.com/0xkinno/vigil

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Built with UiPath Studio Web, Maestro, Agent Builder and Orchestrator

VIGIL

THANK YOU

Every report a case. Every case on the clock. Every serious patient escalated in time.

VIGIL · UiPath AgentHack 2026 · github.com/0xkinno/vigil

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