Chronic Abdominal Pain
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Introduction
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Definition
Chronic abdominal pain is defined:
1Jonathan Gotfried. Chronic Abdominal Pain and Recurrent Abdominal Pain. Merck Manuals.2022 Sept. Available: http://www.msdmanuals.com/professional/gastrointestinal-disorders/symptoms-of-gi-disorders/chronic-and-recurrent-abdominal-pain
2Assessment of chronic abdominal pain. BMJ Best Practise. 2022 Mar. Available: https://bestpractice.bmj.com/topics/en-gb/767
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Classification
Chronic abdominal pain is divided into organic and functional aetiologies.
3Tolba, R., Shroll, J., Kanu, A., Rizk, M.K. (2015). The Epidemiology of Chronic Abdominal Pain. In: Kapural, L. (eds) Chronic Abdominal Pain. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1992-5_2
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Epidemiology
Epidemiological data suggest that the incidence of unspecified abdominal pain is 22.9 per 1000 person-years 3.
A cross-sectional survey among adult population reported as high as 25% have abdominal pain at one time 3. In a systemic review of chronic abdominal pain in children and adolescents, the prevalence rate ranged is 4 to 53% 4.
3Tolba, R., Shroll, J., Kanu, A., Rizk, M.K. (2015). The Epidemiology of Chronic Abdominal Pain. In: Kapural, L. (eds) Chronic Abdominal Pain. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1992-5_2
4Banez GA. Recurrent abdominal pain in children and adolescents: Classification, epidemiology and etiology/conceptual models.
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Epidemiology
Diagnosis and management is often challenging at primary health care setting.
Factors that contribute to this include:
2Assessment of chronic abdominal pain. BMJ Best Practise. 2022 Mar. Available: https://bestpractice.bmj.com/topics/en-gb/767
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Common 10 diagnosis of chronic abdominal pain at primary health care level
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It is important to rule out any red flag:
1. Acute Coronary Syndrome
2. Malignancy
3. MARK’s Quadrant Score > 10
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Flow chart management of chronic abdominal pain in primary health care
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It is important to rule out any red flag:
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Thank You
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Functional Dyspepsia
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Functional Dyspepsia
Prevalence: 10-30% 7
Clinical Features
• ROME IV : Presence of at least one of the following:
• Postprandial fullness ( 3 days per week)
• Early satiety ( 3 days per week)
• Epigastric pain (1 day per week)
• Epigastric burning ( 1 day per week)
AND
• No evidence of structural disease
* Criteria must be present for at least the past three months, with symptoms starting at least six months before diagnosis.
7 Theodor A, Roxana G et al. Functional Dyspepsia Today. Maedica (Buchar). 2013 Mar; 8(1): 68–74
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Functional Dyspepsia
Functional dyspepsia accounts for 70% of dyspepsia.
Diagnosis of exclusion, therefore, evaluation for a more serious disease eg malignancy is warranted.
Medication history should be taken to assess for any drugs that are associated with dyspepsia.
e.g. Acarbose, Antibiotics, Bisphosponates, Corticosteroids, Iron, Metformin, NSAIDs, Orlistat, Theophylline, Potassium chloride
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Functional Dyspepsia
Physical Examination/ Investigations:
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Functional Dyspepsia
Management
• Dietary Modification
• Limit foods associated with functional dyspepsia e.g. foods high in fat, wheat, FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols), and naturally occurring food chemicals such as caffeine.
• Avoid drugs associated with dyspepsia
• H2 Receptors Antagonist (Ranitidine) / PPI (Pantoprazole) (Epigastric pain syndromes)
• Prokinetics (Metoclopramide/ Domperidone) for 4 weeks (Post- prandial distress syndrome)
• Psychological therapy (e.g. Cognitive Behaviour Therapy)
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Functional Dyspepsia
Refer Surgical or Gastro if
• No response to treatment for 4 weeks
• Alarm symptoms (profound weight loss, anemia, epigastric mass, enlarged supraclavicular lymph node)
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Gastroesophageal Reflux Disease (GERD)
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Gastroesophageal Reflux Disease (GERD)
Prevalence
• SEA and West Asia: 6.3-18.3% 8
Clinical Features
• Typical symptoms: Heartburn, regurgitation, dysphagia 9
• Atypical symptoms: dyspepsia, epigastric pain, nausea, bloating and belching may be indicative to GERD 9
• Extra oesophageal symptoms: chronic cough, asthma and chronic laryngitis
8Hye-Kyung Jung. Epidemiology of Gastroesophageal Reflux Disease in Asia: A systemic review (JNM) Journal Neurogastroenterology Motil, Vol. 17 No.1 January, 2011
9Philip O, Lauren B, Marcelo F. Guidelines for the Diagnosis and Management of GERD. Am J Gastroenterol 2013;108:308-328
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Gastroesophageal Reflux Disease (GERD)
Physical Examination/Investigations
• Normal physical findings
Investigations – not needed 11
11John Murtagh. John Murtagh’s general practice. Dyspepsia (indigestion).4th edition. Chap 47:511-520
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Gastroesophageal Reflux Disease (GERD)
Management
• Exclude cardiac cause
• Extra oesophageal symptoms; need careful evaluation for non-GERD causes 9
• Non-pharmacotherapy
• Lifestyle modification
• Avoid drugs (11): Anticholinergics, Theophylline, CCB.
• If taking drugs like Tetracycline, Slow Release Potassium, Iron sulphates, Corticosteroids and NSAIDS - use ample fluids to swallow medications.
• Pharmacotherapy
• PPI for 8 weeks
9Philip O, Lauren B, Marcelo F. Guidelines for the Diagnosis and Management of GERD. Am J Gastroenterol 2013;108:308-328
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Gastroesophageal Reflux Disease (GERD)
Refer for endoscopy if
• Failed treatment with PPI after 2 months
• Presence of red flag
• High risk group
• History of Barret’s oesophagus
• Dysphagia
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Gastroesophageal Reflux Disease (GERD)
Refer for endoscopy if
• Failed treatment with PPI after 2 months
• Presence of red flag
• High risk group
• History of Barret’s oesophagus
• Dysphagia
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Peptic Ulcer Disease (PUD)
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Peptic Ulcer Disease (PUD)
Prevalence
• 1-year prevalence based on physician diagnosis was 0.12–1.50% 13
Clinical Features
• History of smoking, NSAIDS, Aspirin, H.pylori infection 14
• Epigastric pain; gnawing or burning sensation especially after meal 14
• Fullness, bloatedness, nausea, vomit a few hours after meal, dyspepsia, heartburn, chest discomfort, hematemesis, melena or symptoms of anaemia 14
Physical Examination/Investigations
• Epigastric tenderness, melena
• FBC for anaemia
13Sung JJY, Kuipers EJ et al. Alimentary Pharmacology & Therapeutics. Vol 29, Issue 9, Article first published online: 10 FEB 2009 Systematic review: the global incidence and prevalence of peptic ulcer disease
14BS Anand et al. Peptic Ulcer Disease. Medscape 2021 Apr.
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Peptic Ulcer Disease (PUD)
Management
• Stop NSAIDS 15 Aspirin
Prevention:
• If NSAIDS is needed, choose COX-2 selective inhibitor at the lowest efficacy dose plus daily PPI 16
• If Aspirin is needed as secondary CVD prevention, consider long term PPI therapy 16
• If Aspirin was given for primary prevention, antiplatelet should not be resumed
• Quit smoking
• Offer full dose PPI eg. Pantoprazole 40mg OD or H2RA therapy for 8 weeks 15
Refer SOPD/ Gastro for OGDS
RED FLAG: Anaemia, Early satiety, Unexplained weight loss, dysphagia/ odynophagia, recurrent vomiting, Family history GI cancer
15Sung JJY, Kuipers EJ et al. Alimentary Pharmacology & Therapeutics. Vol 29, Issue 9, Article first published online: 10 FEB 2009 Systematic review: the global incidence and prevalence of peptic ulcer disease
16Laine, Loren; Jensen, Dennis M. Management of Patients With Ulcer Bleeding. American Journal of Gastroenterology 107(3):p 345-360, March 2012.
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Irritable Bowel Syndrome (IBS)
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Irritable Bowel Syndrome (IBS)
Prevalence: 7-10% in the world 17
Clinical Features
• Diagnosis-ROME III Criteria: Recurrent abdominal pain or discomfort at least 3 months associated with≥ 2 of the following:
• Improvement with defecations
• Onset associated with a change in frequency of stool
• Onset associated with a change in form(appearance) of stool
• Altered stool passage (straining, urgency, incomplete evacuation)
• Abdominal bloating, distension, tension or hardness
• Symptom made worse by eating
• Passage of mucus
• Age onset 20-30y
17 Lisa G. Practice Guidelines. ACG Releases Recommendations on the Management of Irritable Bowel Syndrome; Am Fam Physician. 2009 Jun; 79 (12):1108 – 1117.
19 Irritable bowel syndrome in adults: diagnosis and management Clinical guideline [CG61]Published: 23 February 2008 Last updated: 04 April 2017
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Irritable Bowel Syndrome (IBS)
Physical Examination/Investigations
• Overall healthy or maybe tense or anxious
• May have sigmoid tenderness or palpable sigmoid cord 20
No Investigations for age <50year old with typical IBS sign and symptoms 19
19 Irritable bowel syndrome in adults: diagnosis and management Clinical guideline [CG61]Published: 23 February 2008 Last updated: 04 April 2017
20 Jenifer K Lehrer et al. Irritable Bowel Syndrome (IBS). Medscape Feb 15, 2022.
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Irritable Bowel Syndrome (IBS)
Management
• Lifestyle advice: Increase physical activity & Dietary advice 19
Pharmacotherapy 19:
• Consider antispasmodic agent; to take as required
• Laxative for constipation, not lactulose (specific laxative)
• Loperamide for diarrhoea
• Antidepressant if all above not help
Refer surgical or gastro if having alarm features such as:
• Loss of weight
• Anaemia
• Family History of GI organic disease eg IBD, Colon Cancer
19 Irritable bowel syndrome in adults: diagnosis and management Clinical guideline [CG61]Published: 23 February 2008 Last updated: 04 April 2017
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Gallbladder Disease
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Gallbladder Disease
Pain due to
• a gallstone which blocks the bile duct (biliary colic)
• it may become chronic if it recurs for more than 3 months
• Pain Quality: severe colicky pain, short lived with associated sweating.
• the pain goes away if the stone passes into the small intestine and unblocks the duct.
• Pain especially after fatty meal.
Site
• Right upper quadrant, but also epigastrium and other parts of the abdomen.
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Gallbladder Disease
Factors that may increase risk of gallstones
• Female
• Age 40 or older
• Overweight or obese
• Sedentary
• Pregnant
• Eating a high-fat diet
• Eating a high-cholesterol diet
• Eating a low-fibre diet
• Having a family history of
gallstones
• Having diabetes
• Having certain blood disorders, such as sickle cell anaemia or leukaemia
• Losing weight very quickly
• Taking medications that contain estrogenic, such as oral contraceptives or hormone therapy drugs
• Having liver disease
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Gallbladder Disease
Radiology
• Abdominal x-ray has limited use to diagnose gallstone.
• Ultrasound Abdomen is the best imaging test for detecting gallstones. (only rarely are cholecystograms needed).
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Gallbladder Disease
Management:
• Pain relief with antispasmodics (Hyoscine)
• IM Diclofenac in patients with severe pain
• Refer surgery
• The usual treatment for chronic gallstones with pain is removal of the gallbladder.
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Nephrolithiasis
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Nephrolithiasis
Clinical Features
• History of recurrent renal colic pain-severe pain from flank and radiate inferiorly and anteriorly
• History of urinary tract calculi
• UTI
• Haematuria
• Urinary symptoms – stones lodged at ureterovesical junction (frequency, dysuria), stones lodged at intramural ureter (suprapubic pain, frequency, urgency, dysuria, stranguria, pain tip of penis)
• Asymptomatic in small, non-obstructing stone or staghorn calculi
• Family history of renal calculi 25
25Chirag N Dave. Nephrolithiasis. Medscape Sep 16, 2021 .
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Nephrolithiasis
Physical Examination/ Investigations
• Abdomen – unremarkable
• UFEME, Renal profile, Serum Uric Acid
• Serum calcium/ phosphate and ± Serum parathyroid
• Plain KUB Xray
• KUB USG
• CT Urogram (CTU)-indicated if USG and KUB x rays negative for stone despite strong suspicion of urolithiasis/ persistent haematuria
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Nephrolithiasis
Management
• Dietary modifications-increase fluid intake (8 glasses/day), Low salt and protein diet
• Dietary calcium: 600 – 800mg/day
• Medications: Alkalizing agent
• Allopurinol if evidence of uric acid stones
Refer urologist if
• Stones >6 mm 25
• Deranged renal profile(urgent referral)
• USG showed obstructive uropathy (urgent referral)
25Chirag N Dave. Nephrolithiasis. Medscape Sep 16, 2021 .
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Primary Dysmenorrhea
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Primary Dysmenorrhea
90% common cause of dysmenorrhea
Clinical features
• Onset menarche, Duration 48-72 hours
• Cramping or labor like pain
• Constant lower abdominal pain, radiating to the back or thigh
PE/Ix
• Normal pelvic examination
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Primary Dysmenorrhea
Management
• Reassurance
• Non-medical therapy: High frequency TENS, Acupuncture
• Medical therapy
• NSAID
• Oral contraceptive
• Depot medroxyprogesterone/ levonorgestrel intrauterine system
Refer gynae if indication for surgery or suspected secondary cause
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Pelvic Inflammatory Disease (PID)
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Pelvic Inflammatory Disease (PID)
Prevalence
• The number of visits to physicians for PID among women aged 15–44 was 39.8% (29)
Clinical Features
• History of high-risk sexual behaviour
• History of instrumentation of uterus insertion
• Abnormal vaginal or cervical discharge
• Lower abdominal pain
• Abnormal vaginal bleeding: Intermenstrual bleeding, Post-Coital Bleeding, Menorrhagia
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Pelvic Inflammatory Disease (PID)
Physical Examination/ Investigations
• Febrile (>38 °C), lower abdominal tenderness, Adnexal or Cervical motion tenderness
Ix:
• Tests for Gonorrhoea and Chlamydia (Gram stain, Culture & Sensitivity), FBC, UFEME
• Ultrasound, Diagnostic Laparoscopy
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Pelvic Inflammatory Disease (PID)
Management
• Safe sex
• Educate on long term complication
• Appropriate analgesia (WHO Analgesic Ladder approach)
• Broad spectrum antibiotic to cover N.Gonorrhoea, C. Trachomatis and anaerobic infection
Referral if diagnosis uncertain, severe symptoms, presence of a tubo- ovarian abscesses, inability to tolerate an oral regime and pregnancy.
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Chronic Abdominal Wall Pain
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Chronic Abdominal Wall Pain
Prevalence:
• 10-90%
• Common causes of Abdominal Wall pain
• Nerve entrapment
• Hernia
• Surgical and procedural complication
Clinical Features
• Pain more common at right side of abdomen
• Usually sharp to extreme tenderness on upon gentle stroking or pinching.
• Exacerbated by tight clothing, obesity or post-operative scarring
• Relief by sitting, lying or relatively frequently by hand-splinting the affected area
• Aggravated by standing, lifting, stretching, eating, defecation and coughing
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Chronic Abdominal Wall Pain
Physical examination/Investigations
• Proper physical examination including Carnett’s test and investigation to find out the cause
• Diagnosis by exclusion
• Assess severity by Trigger Point Injection (TPI) by trained specialist (FMS / Pain Specialist)
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Chronic Abdominal Wall Pain
Management
• Reassurance
• Breathing exercises
• Mild pain
• minimizing activities that aggravate the pain
• An abdominal binder.
For moderate to severe pain:
• Modification of physical activities
• Local nerve blocks or trigger point injections using anaesthetic/ steroid injections by trained specialist (FMS / Pain Specialist)
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Infective Gastroenteritis
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Infective Gastroenteritis
Clinical Features
• history of travel to endemic areas;
• greasy, foul-smelling stools;
• diarrhoea (may be bloody, depending on organism, but most chronic forms are nonbloody);
• tenesmus,
• fever, chills
• immunosuppressed patients at higher risk
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Infective Gastroenteritis
Physical examination/Investigations
• Nonspecific physical examination
• Stool culture: positive culture for Escherichia coli, Shigella , Salmonella , or Campylobacter
• Stool ova and parasites: positive
• Stool assay for Clostridium difficile toxin: positive (Indicated if there is a history of recent antibiotic use or in hospitalized patients).
• Sigmoidoscopy/ colonoscopy with biopsy: microbiologic and/or histologic confirmation of infection
• Endoscopic exam is not required in the vast majority of patients with gastroenteritis.
• In patients with negative cultures, or persistent diarrhoea and no improvement with conservative management, sigmoidoscopy should be performed to exclude other causes of diarrhoea.
• Colonoscopy is rarely required, and is usually postponed until colonic inflammation has resolved.
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Infective Gastroenteritis
Management
• Treat according to causative organism.
• Do not use anti-diarrheal agent.
• Hydration
• Antimuscuranic (Hyoscine Butylbromide)
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