Marc Vaudel
Center for Medical Genetics and Molecular Medicine, �Haukeland University Hospital, Bergen, Norway
�Center for Diabetes Research, Department of Clinical Science, University of Bergen, Norway
Gene RNA protein abundance
22.06.21
THREE LEVELS [2015]�TYLER HOBBS
Comparing gene, RNA, and �protein abundances
Gene > transcript > peptide > protein > proteoform
What is the right level to compare transcript and protein abundance?
3
Genotype vs. peptide abundance
What can explain the difference between expected and observed distributions?
4
Copy number attenuation
What can be the source of copy number attenuation?
5
RNA vs. protein abundance
How can we take advantage of the RNA-protein correlation – or lack thereof?
6
RNA vs. protein abundance
7
From genes to proteoforms
8
From genes to proteoforms
9
How can we take advantage of the combination of these analytical layers?
From genotypes to phenotypes
10
How would you use the association of genetic variants with biomarkers?
Acknowledgement