Fibrosis : New Way of Thinking
Gastroenterology-2019
Gastroenterology-2019
Incision and Excision will decided
Fibrosis is often defined as a wound-healing response that has gone out of control
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804380/
Gastroenterology-2019
Keloids: Current concepts of pathogenesis (Review)
GREGOR M. BRAN, ULRICH R. GOESSLER, KARL HORMANN, FRANK RIEDEL and HANEEN SADICK
Equilibrium
https://www.mdpi.com/1422-0067/22/2/897
. Only the epidermis has the capability to fully regenerate (*),
whereas healing of the injured dermis results in scar formation (** and ***).
Injury targeting only papillary dermis ends with normotrophic scar formation (*).
Deeper wounds (reticular parts of the dermis) with prolonged inflammatory response may activate biological pathways resulting in pathological scarring (***).
Critical depth of injury
Normotrophic
vs
Pathological scar
Seed vs Soil
Always Favorable