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Orchestrating Genomics Data with Overture

Overture

Overture at MCBK-NA

Overture.bio

Overture-Stack

mshiell@oicr.on.ca

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Data and Discovery

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Overture at MCBK-NA

Data and Discovery

Clinical Data

Genomics Data

Data is information at a granular level

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Overture at MCBK-NA

Data and Discovery

Corner

Edge

Metadata is critical, however interpretation is still required

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Overture at MCBK-NA

Data and Discovery

Interpretation of rich data creates new usable knowledge

Usable Knowledge

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Overture at MCBK-NA

Data and Discovery

Creating this knowledge requires computational tools to mobilize data and make it widely discoverable for safe and fair use.

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Overture at MCBK-NA

Our group has specialized in filling the gaps between genomics data and the researchers who need that data to drive discovery.

Data and Discovery

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Overture at MCBK-NA

Building Discovery Platforms

IHCC

PCGL

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Building Discovery Platforms

Overture at MCBK-NA

IHCC

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Overture at MCBK-NA

Building Discovery Platforms

IHCC

PCGL

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Portal UI

Portal UI

Search AP

File Transfer

Indexing

Search API

Metadata Management

File Transfer

Indexing

Metadata Management

Overture at MCBK-NA

Core Requirements

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  • Reducing redundant programming efforts

  • Building and deploying flexible and scalable genomics data platforms

File Transfer

Indexing

Metadata Management

File Transfer

Indexing

Metadata Management

Stage

Portal UI

Song

Metadata

Management

Score

File Transfer

Maestro

Indexing

Arranger Search API

Overture at MCBK-NA

Overture Microservices

Portal UI

Portal UI

Portal UI

Search AP

Search API

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Song

Metadata

Management

Score

File Transfer

Maestro

Indexing

Stage

Portal UI

Kids First

HCMI

IHCC

VirusSeq

ICGC-ARGO

Overture at MCBK-NA

Overture Microservices

Arranger Search API

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Meta(data) Management

Overture at MCBK-NA

Submission

Metadata

Validation

Admin Defined

Schema

Global Identifiers

VCFs, BAMs, CRAMs

Multipart

file transfers

File Tracking

Song

Score

Maestro

Arranger

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Metadata Indexing

Overture at MCBK-NA

Song

Score

Maestro

Arranger

Elasticsearch

Index

Federated Song

Databases

Maestro

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Arranger Search

Overture at MCBK-NA

Song

Score

Maestro

Arranger

Arranger

Components

Arranger

Server

Elasticsearch

Index

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Arranger Search

Overture at MCBK-NA

Song

Score

Maestro

Arranger

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Arranger Search

Overture at MCBK-NA

Arranger

Components

Arranger

Server

SQON filter notation

Song

Score

Maestro

Arranger

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Overture at MCBK-NA

Building with Overture

  • If you have data and knowledge and want to make it discoverable, our tools can help

  • We want to hear your ideas and finds ways in how we can better meet your needs

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Overture at MCBK-NA

Building with Overture

  • Academic Collaborations

  • Technical Consulting

  • Mutually beneficial development

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Overture at MCBK-NA

Overture.bio

Overture-Stack

mshiell@oicr.on.ca

Where to find us

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Creating and promoting big data tools for those advancing the knowledge and treatment of cancer.

Mélanie Courtot

Director & Principal Investigator

Alexis Li

Business Analyst

Dan DeMaria

Software Developer

Linda Xiang

Bioinformatician

Andres Melani

PhD Student

Edmund Su

Bioinformatician

Mitchell Shiell

Outreach Lead

Andrew Xu

Co-op Student

Guanqiao Feng

Bioinformatician

Patrick Dos Santos

UI/UX Designer

Azher Ali Mohammed

Software Developer

Hardeep Nahal-Bose

Bioinformatician

Puneet Bajwa

Project Manager

Ann Catton

Software Developer

Henrich Feher

DevOps

Rakesh Mistry

Software Developer

Azher Ali Mohammed

Software Developer

Jared Baker

Cloud Specialist

Robin Haw

Program Manager

Bhavik BhagatBusiness Analyst

Jon Eubank

Associate Technical Director

Samantha Rich

Software Developer

Brandon Chan

Business Analyst

Justin Richardsson

Associate Technical Director

Ummulkiram Rangwala

Software Developer

Ciarán Schütte

Software Developer

Leonardo Rivera

Software Developer

Yelizar Alturmessov

DevOps

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Overture is supported by grant #U24CA253529 from the National Cancer Institute at the US National Institutes of Health, and additional funding from Genome Canada, the Canada Foundation for Innovation, the Canadian Institutes of Health Research, Canarie, and the Ontario Institute for Cancer Research.

Funding provided by the �Government of Ontario.

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Overture at MCBK-NA

Overture.bio

Overture-Stack

mshiell@oicr.on.ca

Where to find us